ICD-Topo |
C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
ICD-Morpho |
9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
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ICD-Morpho |
9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
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ICD-Morpho |
9989/3 Myelodysplastic syndrome, unclassifiable
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Atlas_Id |
1159 |
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dic(1;15)(p11;p11) G- banding - Courtesy Catherine Roche-Lestienne, Olivier Theisen, Jean-Luc Lai. |
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Disease |
Myeloid malignancies |
Phenotype / cell stem origin |
Myloproliferative diseases (MPD) in 3 of 10 available cases (polycytemia vera (PV) in all 3 cases), myelodysplastic syndromes (MDS) in 6 cases (mainly refractory anaemia (RA): 5 cases; RARS in one case), acute myeloid leukaemia (AML) of M7 type in one case. |
Epidemiology | At least 10 cases; balanced sex ratio (5M/5F); median age was 47 yrs (range 15-81) |
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| Kaplan-Meier on 10 cases of dic(1;15) from the literature; survivals (in months) were: 4, 14, 23+, 24+, 27, 40+, 93+, 96, 235. |
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Prognosis | About 60% of cases were still alive 2 to 8 yrs after diagnosis (see figure1), but with a too short follow up of a too small cohort, no real conclusions can be drawn. It is likely that the prognosis depend more on the haematological diagnosis (AML versus MDS, vs MPD). |
Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH). |
Dastugue N, Lafage-Pochitaloff M, Pagès MP, Radford I, Bastard C, Talmant P, Mozziconacci MJ, Léonard C, Bilhou-Nabéra C, Cabrol C, Capodano AM, Cornillet-Lefebvre P, Lessard M, Mugneret F, Pérot C, Taviaux S, Fenneteaux O, Duchayne E, Groupe Français d'Hematologie Cellulaire, Berger R |
Blood. 2002 ; 100 (2) : 618-626. |
PMID 12091356 |
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Cytogenetic analysis of 54 cases of myelodysplastic syndrome. |
Jotterand-Bellomo M, Parlier V, Schmidt PM, Beris P |
Cancer genetics and cytogenetics. 1990 ; 46 (2) : 157-172. |
PMID 2340487 |
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A dysmorphic child with myelodysplasia characterized by a duplication of 1q and multiple duplications of 3q. |
Mascarello JT, Osborn C, Kadota RP |
Cancer genetics and cytogenetics. 1989 ; 38 (1) : 9-12. |
PMID 2713819 |
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An identical translocation between chromosome 1 and 15 in two patients with myelodysplastic syndromes. |
Mecucci C, Tricot G, Boogaerts M, Van den Berghe H |
British journal of haematology. 1986 ; 62 (3) : 439-445. |
PMID 3954964 |
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Dicentric (1;15) in myeloid disorders. |
Michaux L, Dierlamm J, Mecucci C, Meeus P, Ameye G, Libouton JM, Verhoef G, Ferrant A, Louwagie A, Verellen-Dumoulin C, Van Den Berghe H |
Cancer genetics and cytogenetics. 1996 ; 88 (1) : 86-89. |
PMID 8630988 |
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Trisomy 1q in polycythemia vera and its relation to disease transition. |
Swolin B, Weinfeld A, Westin J |
American journal of hematology. 1986 ; 22 (2) : 155-167. |
PMID 3706291 |
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Cytogenetic studies in polycythemia vera. |
Wurster-Hill D, Whang-Peng J, McIntyre OR, Hsu LY, Hirschhorn K, Modan B, Pisciotta AV, Pierre R, Balcerzak SP, Murphy S, Weinfeld A |
Seminars in hematology. 1976 ; 13 (1) : 13-32. |
PMID 1251221 |
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