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dic(1;15)(p11;p11)

Written2007-08Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

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Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1159
 
  dic(1;15)(p11;p11) G- banding - Courtesy Catherine Roche-Lestienne, Olivier Theisen, Jean-Luc Lai.

Clinics and Pathology

Disease Myeloid malignancies
Phenotype / cell stem origin Myloproliferative diseases (MPD) in 3 of 10 available cases (polycytemia vera (PV) in all 3 cases), myelodysplastic syndromes (MDS) in 6 cases (mainly refractory anaemia (RA): 5 cases; RARS in one case), acute myeloid leukaemia (AML) of M7 type in one case.
Epidemiology At least 10 cases; balanced sex ratio (5M/5F); median age was 47 yrs (range 15-81)
 
Kaplan-Meier on 10 cases of dic(1;15) from the literature; survivals (in months) were: 4, 14, 23+, 24+, 27, 40+, 93+, 96, 235.
Prognosis About 60% of cases were still alive 2 to 8 yrs after diagnosis (see figure1), but with a too short follow up of a too small cohort, no real conclusions can be drawn. It is likely that the prognosis depend more on the haematological diagnosis (AML versus MDS, vs MPD).

Cytogenetics

Cytogenetics Morphological presents as-15, + dic(1;15) in most, if not all, cases. It therefore results in trisomy 1q.; sole anomaly in about half cases, accompanied with del(5q) twice, +8 once, del(20q) once.

Genes involved and Proteins

Note Genes involved are unknown; the translocation breakpoints are likely to be in heterochromatic regions

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.
Case Report Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD
Case Report Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera
Case Report Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome
Case Report A new case of dic(1;15) in essential thrombocythaemia with JAK2 V617F mutation
Case Report A new case of dic(1;15) in essential thrombocythaemia with JAK2 V617F mutation

Bibliography

Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH).
Dastugue N, Lafage-Pochitaloff M, Pagès MP, Radford I, Bastard C, Talmant P, Mozziconacci MJ, Léonard C, Bilhou-Nabéra C, Cabrol C, Capodano AM, Cornillet-Lefebvre P, Lessard M, Mugneret F, Pérot C, Taviaux S, Fenneteaux O, Duchayne E, Groupe Français d'Hematologie Cellulaire, Berger R
Blood. 2002 ; 100 (2) : 618-626.
PMID 12091356
 
Cytogenetic analysis of 54 cases of myelodysplastic syndrome.
Jotterand-Bellomo M, Parlier V, Schmidt PM, Beris P
Cancer genetics and cytogenetics. 1990 ; 46 (2) : 157-172.
PMID 2340487
 
A dysmorphic child with myelodysplasia characterized by a duplication of 1q and multiple duplications of 3q.
Mascarello JT, Osborn C, Kadota RP
Cancer genetics and cytogenetics. 1989 ; 38 (1) : 9-12.
PMID 2713819
 
An identical translocation between chromosome 1 and 15 in two patients with myelodysplastic syndromes.
Mecucci C, Tricot G, Boogaerts M, Van den Berghe H
British journal of haematology. 1986 ; 62 (3) : 439-445.
PMID 3954964
 
Dicentric (1;15) in myeloid disorders.
Michaux L, Dierlamm J, Mecucci C, Meeus P, Ameye G, Libouton JM, Verhoef G, Ferrant A, Louwagie A, Verellen-Dumoulin C, Van Den Berghe H
Cancer genetics and cytogenetics. 1996 ; 88 (1) : 86-89.
PMID 8630988
 
Trisomy 1q in polycythemia vera and its relation to disease transition.
Swolin B, Weinfeld A, Westin J
American journal of hematology. 1986 ; 22 (2) : 155-167.
PMID 3706291
 
Cytogenetic studies in polycythemia vera.
Wurster-Hill D, Whang-Peng J, McIntyre OR, Hsu LY, Hirschhorn K, Modan B, Pisciotta AV, Pierre R, Balcerzak SP, Murphy S, Weinfeld A
Seminars in hematology. 1976 ; 13 (1) : 13-32.
PMID 1251221
 

Citation

This paper should be referenced as such :
Huret, JL
dic(1;15)(p11;p11)
Atlas Genet Cytogenet Oncol Haematol. 2008;12(4):344-345.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/dic0115p11p11ID1159.html

Translocations implicated (Data extracted from papers in the Atlas)

 dic(1;15)(p11;p11)

External links

Mitelman databasedic(1;15)(p11;p11) [Case List]    dic(1;15)(p11;p11) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9975/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
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