Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Written2005-09Sabine Strehl
Children's Cancer Research Institute, Kinderspitalgasse 6, A-1090 Vienna, Austria

(Note : for Links provided by Atlas : click)


ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
Atlas_Id 1054
  dic(7;9)(p11-13;p11) G-banding ­ Courtesy Cytogenetics Laboratory of the CCRI, Children¹s Cancer Research Institute, Vienna.

Clinics and Pathology

Disease ALL
Phenotype / cell stem origin FAB L1 phenotype; pre-B immunophenotype, cIg+ or cIg-
Epidemiology < 1% of childhood ALL, age ≤ 6 years; 3% of childhood ALL with 9p abnormalities; rarely also found in elderly ALL patients; occasionally associated with Ph+ ALL.
Clinics Organomegaly
Prognosis Unknown


Note Several dicentric chromosomes found in childhood ALL are formed from the q arms of chromosomes 7, 9, 12, and, 17 with partial loss of the respective p arms.
Cytogenetics Morphological Unbalanced; formation of a dicentric chromosome resulting in partial monosomies of 7p and 9p -> hypodiploid with 45 chromosomes.
Additional anomalies del(6q), dup(1p), del(8)(p22),...

Genes involved and Proteins

Note Genes involved are unknown.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.
Case Report Dicentric dic(7;9)(p11;p11): a new case in childhood ALL


Collaborative study of karyotypes in childhood acute lymphoblastic leukemias. Groupe Français de Cytogénétique Hématologique (GFCH).
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1993 ; 7 (1) : 10-19.
PMID 8418369
Deletions of interferon genes in acute lymphoblastic leukemia.
Diaz MO, Rubin CM, Harden A, Ziemin S, Larson RA, Le Beau MM, Rowley JD
The New England journal of medicine. 1990 ; 322 (2) : 77-82.
PMID 2294436
Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group.
Heerema NA, Nachman JB, Sather HN, La MK, Hutchinson R, Lange BJ, Bostrom B, Steinherz PG, Gaynon PS, Children's Cancer Group, Uckun FM
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2004 ; 18 (5) : 939-947.
PMID 14999294
Screening for specific chromosome involvement in hematological malignancies using a set of seven chromosome painting probes. An alternative approach for chromosome analysis using standard FISH instrumentation.
Nacheva EP, Gribble S, Andrews K, Wienberg J, Grace CD
Cancer genetics and cytogenetics. 2000 ; 122 (2) : 65-72.
PMID 11106813
Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia.
Raimondi SC, Zhou Y, Mathew S, Shurtleff SA, Sandlund JT, Rivera GK, Behm FG, Pui CH
Cancer. 2003 ; 98 (12) : 2715-2722.
PMID 14669294
Acute lymphoblastic leukemia in the elderly: The Edouard Herriot Hospital experience.
Thomas X, Olteanu N, Charrin C, Lhéritier V, Magaud JP, Fiere D
American journal of hematology. 2001 ; 67 (2) : 73-83.
PMID 11343378
Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group.
Uckun FM, Nachman JB, Sather HN, Sensel MG, Kraft P, Steinherz PG, Lange B, Hutchinson R, Reaman GH, Gaynon PS, Heerema NA
Cancer. 1998 ; 83 (9) : 2030-2039.
PMID 9806664
Detection of chromosome over- and underrepresentations in hyperdiploid acute lymphoblastic leukemia by comparative genomic hybridization.
Wong N, Chen SJ, Cao Q, Su XY, Niu C, Wu QW, Leung TW, Wickham N, Johnson PJ, Chen Z
Cancer genetics and cytogenetics. 1998 ; 103 (1) : 20-24.
PMID 9595040


This paper should be referenced as such :
Strehl, S
Atlas Genet Cytogenet Oncol Haematol. 2006;10(2):110-111.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databasedic(7;9)(p11;p11) [Case List]    dic(7;9)(p11;p11) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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