dic(7;9)(p11-13;p11)

Identity

	dic(7;9)(p11-13;p11) G-banding ­ Courtesy Cytogenetics Laboratory of the CCRI, Children¹s Cancer Research Institute, Vienna.

Clinics and Pathology

Disease	ALL
Phenotype / cell stem origin	FAB L1 phenotype; pre-B immunophenotype, cIg+ or cIg-
Epidemiology	<1% of childhood ALL, age £ 6 years; 3% of childhood ALL with 9p abnormalities; rarely also found in elderly ALL patients; occasionally associated with Ph+ ALL
Clinics	organomegaly
Prognosis	unknown

Cytogenetics

Note	Several dicentric chromosomes found in childhood ALL are formed from the q arms of chromosomes 7, 9, 12, and, 17 with partial loss of the respective p arms.
Cytogenetics Morphological	unbalanced; formation of a dicentric chromosome resulting in partial monosomies of 7p and 9p -> hypodiploid with 45 chromosomes
Additional anomalies	del(6q), dup(1p), del(8)(p22),...

Genes involved and Proteins

Note	Genes involved are unknown.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section.

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Contributor(s)

Written	09-2005	Sabine Strehl

Citation

This paper should be referenced as such :

Strehl S . dic(7;9)(p11-13;p11). Atlas Genet Cytogenet Oncol Haematol. September 2005 . URL : http://AtlasGeneticsOncology.org/Anomalies/dic0709p11p11ID1054.html

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indexed on : Mon May 12 18:11:38 2008

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