| Written | 1999-06 | Barbara Gibbons |
| NE London Regional Cytogenetics Laboratory 2nd Floor, Queen Square House Institute of Neurology Queen Square London WC1N 3BG, UK |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9811/3 B lymphoblastic leukaemia/lymphoma, NOS |
| ICD-Morpho | 9816/3 B lymphoblastic leukaemia/lymphoma with hypodiploidy (Hypodiploid ALL) |
| Atlas_Id | 1087 |
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| Hypoploidy R- banding - Courtesy Jean-Luc Lai | |
| Clinics and Pathology |
| Disease | acute lymphoblastic leukemia (ALL) |
| Epidemiology | a very rare type of leukaemia, primarily of young adults |
| Cytology | vacuolated small and large blasts |
| Prognosis | poor prognosis with short complete remission duration |
| Cytogenetics |
| Cytogenetics Morphological | ALL with severe hypodiploidy is characterised by chromosome number ranging from 30-39 and the chromosomes commonly retained are copies of 1, 4, 5, 6, 8, 9, 10, 11, 18, 19, 21, 22, and the sex chromosomes; cells with double the hypodiploid number may also be present |
| Bibliography |
| Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups. |
| Callen DF, Raphael K, Michael PM, Garson OM |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 749-752. |
| PMID 2779290 |
| Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line. |
| Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG |
| Blood. 1990 ; 75 (5) : 1170-1177. |
| PMID 2306521 |
| Citation |
| This paper should be referenced as such : |
| Gibbons, B |
| Severe hypodiploid acute lymphoblastic leukaemia |
| Atlas Genet Cytogenet Oncol Haematol. 1999;3(3):151-152. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/hypoploidyID1087.html |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Jun 30 11:22:20 CEST 2017 |
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