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Severe hypodiploid acute lymphoblastic leukaemia

Written1999-06Barbara Gibbons
NE London Regional Cytogenetics Laboratory 2nd Floor, Queen Square House Institute of Neurology Queen Square London WC1N 3BG, UK

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9816/3 B lymphoblastic leukaemia/lymphoma with hypodiploidy (Hypodiploid ALL)
Atlas_Id 1087
 
  Hypoploidy R- banding - Courtesy Jean-Luc Lai

Clinics and Pathology

Disease acute lymphoblastic leukemia (ALL)
Epidemiology a very rare type of leukaemia, primarily of young adults
Cytology vacuolated small and large blasts
Prognosis poor prognosis with short complete remission duration

Cytogenetics

Cytogenetics Morphological ALL with severe hypodiploidy is characterised by chromosome number ranging from 30-39 and the chromosomes commonly retained are copies of 1, 4, 5, 6, 8, 9, 10, 11, 18, 19, 21, 22, and the sex chromosomes; cells with double the hypodiploid number may also be present

Bibliography

Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups.
Callen DF, Raphael K, Michael PM, Garson OM
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 749-752.
PMID 2779290
 
Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line.
Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG
Blood. 1990 ; 75 (5) : 1170-1177.
PMID 2306521
 

Citation

This paper should be referenced as such :
Gibbons, B
Severe hypodiploid acute lymphoblastic leukaemia
Atlas Genet Cytogenet Oncol Haematol. 1999;3(3):151-152.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/hypoploidyID1087.html

External links

COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9816/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
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