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Severe hypodiploid acute lymphoblastic leukaemia

Written1999-06Barbara Gibbons
NE London Regional Cytogenetics Laboratory 2nd Floor, Queen Square House Institute of Neurology Queen Square London WC1N 3BG, UK

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Atlas_Id 1087
  Hypoploidy R- banding - Courtesy Jean-Luc Lai

Clinics and Pathology

Disease acute lymphoblastic leukemia (ALL)
Epidemiology a very rare type of leukaemia, primarily of young adults
Cytology vacuolated small and large blasts
Prognosis poor prognosis with short complete remission duration


Cytogenetics Morphological ALL with severe hypodiploidy is characterised by chromosome number ranging from 30-39 and the chromosomes commonly retained are copies of 1, 4, 5, 6, 8, 9, 10, 11, 18, 19, 21, 22, and the sex chromosomes; cells with double the hypodiploid number may also be present


Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups.
Callen DF, Raphael K, Michael PM, Garson OM
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 749-752.
PMID 2779290
Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line.
Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG
Blood. 1990 ; 75 (5) : 1170-1177.
PMID 2306521


This paper should be referenced as such :
Gibbons, B
Severe hypodiploid acute lymphoblastic leukaemia
Atlas Genet Cytogenet Oncol Haematol. 1999;3(3):151-152.
Free journal version : [ pdf ]   [ DOI ]
On line version :

External links

COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
Disease databaseSevere hypodiploid acute lymphoblastic leukaemia
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

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