Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Severe hypodiploid acute lymphoblastic leukaemia


ICD-Topo C770-C775,C778-C779
  Hypoploidy R- banding - Courtesy Jean-Luc Lai

Clinics and Pathology

Disease acute lymphoblastic leukemia (ALL)
Epidemiology a very rare type of leukaemia, primarily of young adults
Cytology vacuolated small and large blasts
Prognosis poor prognosis with short complete remission duration


Cytogenetics Morphological ALL with severe hypodiploidy is characterised by chromosome number ranging from 30-39 and the chromosomes commonly retained are copies of 1, 4, 5, 6, 8, 9, 10, 11, 18, 19, 21, 22, and the sex chromosomes; cells with double the hypodiploid number may also be present

Translocations implicated (Data extracted from papers in the Atlas)


Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups.
Callen DF, Raphael K, Michael PM, Garson OM
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 749-752.
PMID 2779290
Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line.
Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG
Blood. 1990 ; 75 (5) : 1170-1177.
PMID 2306521
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


Written06-1999Barbara Gibbons


This paper should be referenced as such :
Gibbons, B
Severe hypodiploid acute lymphoblastic leukaemia
Atlas Genet Cytogenet Oncol Haematol. 1999;3(3):151-152.
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