Severe hypodiploid acute lymphoblastic leukaemia

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Severe hypodiploid acute lymphoblastic leukaemia

Identity



	Hypoploidy R- banding - Courtesy Jean-Luc Lai

Clinics and Pathology

Disease	acute lymphoblastic leukemia (ALL)
Epidemiology	a very rare type of leukaemia, primarily of young adults
Cytology	vacuolated small and large blasts
Prognosis	poor prognosis with short complete remission duration

Cytogenetics

Cytogenetics Morphological

ALL with severe hypodiploidy is characterised by chromosome number ranging from 30-39 and the chromosomes commonly retained are copies of 1, 4, 5, 6, 8, 9, 10, 11, 18, 19, 21, 22, and the sex chromosomes; cells with double the hypodiploid number may also be present

Bibliography

Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups.

Callen DF, Raphael K, Michael PM, Garson OM

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 749-752.

PMID 2779290

Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line.

Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG

Blood. 1990 ; 75 (5) : 1170-1177.

PMID 2306521

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