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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
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Don't let the Atlas imminent demise
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Severe hypodiploid acute lymphoblastic leukaemia

Identity

ICD-Topo C770-C775,C778-C779 LYMPH NODES
 
  Hypoploidy R- banding - Courtesy Jean-Luc Lai

Clinics and Pathology

Disease acute lymphoblastic leukemia (ALL)
Epidemiology a very rare type of leukaemia, primarily of young adults
Cytology vacuolated small and large blasts
Prognosis poor prognosis with short complete remission duration

Cytogenetics

Cytogenetics Morphological ALL with severe hypodiploidy is characterised by chromosome number ranging from 30-39 and the chromosomes commonly retained are copies of 1, 4, 5, 6, 8, 9, 10, 11, 18, 19, 21, 22, and the sex chromosomes; cells with double the hypodiploid number may also be present

Translocations implicated (Data extracted from papers in the Atlas)

Bibliography

Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups.
Callen DF, Raphael K, Michael PM, Garson OM
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 749-752.
PMID 2779290
 
Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line.
Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG
Blood. 1990 ; 75 (5) : 1170-1177.
PMID 2306521
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

Contributor(s)

Written06-1999Barbara Gibbons

Citation

This paper should be referenced as such :
Gibbons, B
Severe hypodiploid acute lymphoblastic leukaemia
Atlas Genet Cytogenet Oncol Haematol. 1999;3(3):151-152.
Free journal version : [ pdf ]   [ DOI ]
URL : http://AtlasGeneticsOncology.org/Anomalies/hypoploidyID1087.html

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indexed on : Tue Feb 17 18:57:51 CET 2015


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