Written | 1999-06 | Barbara Gibbons |
NE London Regional Cytogenetics Laboratory 2nd Floor, Queen Square House Institute of Neurology Queen Square London WC1N 3BG, UK |
Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
ICD-Morpho | 9811/3 B lymphoblastic leukaemia/lymphoma, NOS |
ICD-Morpho | 9816/3 B lymphoblastic leukaemia/lymphoma with hypodiploidy (Hypodiploid ALL) |
Atlas_Id | 1087 |
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Hypoploidy R- banding - Courtesy Jean-Luc Lai | |
Clinics and Pathology |
Disease | acute lymphoblastic leukemia (ALL) |
Epidemiology | a very rare type of leukaemia, primarily of young adults |
Cytology | vacuolated small and large blasts |
Prognosis | poor prognosis with short complete remission duration |
Cytogenetics |
Cytogenetics Morphological | ALL with severe hypodiploidy is characterised by chromosome number ranging from 30-39 and the chromosomes commonly retained are copies of 1, 4, 5, 6, 8, 9, 10, 11, 18, 19, 21, 22, and the sex chromosomes; cells with double the hypodiploid number may also be present |
Bibliography |
Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups. |
Callen DF, Raphael K, Michael PM, Garson OM |
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 749-752. |
PMID 2779290 |
Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line. |
Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG |
Blood. 1990 ; 75 (5) : 1170-1177. |
PMID 2306521 |
Citation |
This paper should be referenced as such : |
Gibbons, B |
Severe hypodiploid acute lymphoblastic leukaemia |
Atlas Genet Cytogenet Oncol Haematol. 1999;3(3):151-152. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Anomalies/hypoploidyID1087.html |
External links |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:24:43 CET 2020 |
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