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i(X)(p10) in male patients

Written2016-12Tatiana Gindina
R.M. Gorbacheva Research Institute of Pediatric Oncology Hematology and Transplantation at First Saint-Petersburg State Medical University named I.P.Pavlov, Saint-Petersburg, Russia /

Abstract Review on i(X)(p10) in male patients

Keywords Chromosome X; Acute lymphoblastic leukaemia; Follicular lymphoma

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ICD-Topo C420,C421,C424
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9690/3 Follicular lymphoma; Paediatric follicular lymphoma
Atlas_Id 1496

Clinics and Pathology

Disease Extremely rarely i(X)(p10) occurs in male patients; only three cases has been reported in lymphoid malignancies, including ALL (Martineau et al, 1996; Gerr et al., 2010) and Follicular lymphoma (Donti et al., 1988).
Phenotype / cell stem origin Trilineage immunophenotype of lymphoblasts in one patient (Gerr et al, 2010); CD19+,CD10- in another one (Martineau et al, 1996).
Epidemiology Table 1. Reported cases with i(X)(p10).
# Age, gender


133, M


46,X,+i(X)(p10),-Y/46,idem,del(17)(p12p13)/46,idem,del(7)(q32q36),del(17) Martineau et al, 1996
29, M


50,Y,i(X)(p10),add(2)(p25),-13,+mar1~5Gerr et al, 2010
3 57, M


49,XY,+i(X)(q10),+i(X)(p10),add(1)(q?),+12,add(14)(q?)(6)/48,Y,i(X)(q10),+i(X)(p10), add(1),t(2;8)(p12;q24),+12,add(14)(2)/46,XX(2) Donti et al, 1988
Prognosis Survival was 12 months in one case (Gerr et al, 2010).


Additional anomalies Additional chromosome anomalies were observed in all three patients. Extra i(X)(p10) was present in 2 patients (Donti et al., 1988; Martineau et al, 1996). Associated in combination with loss of Y chromosome, del(7q), del(17p) in 1 (Martineau et al., 1996); +12 in the follicular lymphoma case. In all cases, i(X)(p10) is part of a complex karyotype and seems to be a secondary event.

Result of the chromosomal anomaly

Fusion Protein
Oncogenesis The major consequence of this abnormality is loss of several genes on Xq and gain of several genes on Xp, that leads to genetic imbalance.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Isochromosome (X)(p10) in hematologic disorders: FISH study of 14 new cases show three types of centromere signal patterns
Adeyinka A, Smoley S, Fink S, Sanchez J, Van Dyke DL, Dewald G
Cancer Genet Cytogenet 2007 Nov;179(1):25-30
PMID 17981211
Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation
Donti E, Falini B, Giuseppe Pelicci P, Venti Donti G, Rosetti A, Martelli M, Grignani F
Leukemia 1988 Jan;2(1):41-4
PMID 3339903
Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations
Gerr H, Zimmermann M, Schrappe M, Dworzak M, Ludwig WD, Bradtke J, Moericke A, Schabath R, Creutzig U, Reinhardt D
Br J Haematol 2010 Apr;149(1):84-92
PMID 20085575
Isochromosomes in acute lymphoblastic leukaemia: i(21q) is a significant finding
Martineau M, Clark R, Farrell DM, Hawkins JM, Moorman AV, Secker-Walker LM
Genes Chromosomes Cancer 1996 Sep;17(1):21-30
PMID 8889503


This paper should be referenced as such :
Gindina T
i(X)(p10) in male patients;
Atlas Genet Cytogenet Oncol Haematol. in press
On line version :

External links

arrayMap (UZH-SIB Zurich)Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9690/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
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