Written | 2017-02 | Tatiana Gindina |
R.M. Gorbacheva Research Institute of Pediatric Oncology Hematology and Transplantation at First Saint-Petersburg State Medical University named I.P.Pavlov, Saint-Petersburg, Russia / tatgindina@gmail.com |
Abstract | Review on i(X)(q10) in male patients. |
Keywords | Chromosome X; Acute lymphoblastic leukemia; Diffuse large B-cell lymphoma; Follicular Lymphoma. |
Identity |
ICD-Topo | C420,C421,C424 |
ICD-Morpho | 9811/3 B lymphoblastic leukaemia/lymphoma, NOS |
ICD-Morpho | 9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS; Primary DLBCL of the CNS; Primary cutaneous DLBCL, leg type; EBV positive DLBCL of the elderly; DLBCL associated with chronic inflammation; B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma |
ICD-Morpho | 9690/3 Follicular lymphoma; Paediatric follicular lymphoma |
Atlas_Id | 1492 |
![]() | |
i(X)(q10) Partial karyotypes (G-banding) with i(X)(q10). Hybridization with CEP X SpectrumOrange probe specific for the alpha satellite (centromeric) chromosome X region, (Abbott Molecular, US) showing the signal on normal X and on i(X)(q10) chromosomes- Courtesy Adriana Zamecnikova. | |
Clinics and Pathology |
Disease | Extremely rare i(X)(q10) occurs in male patients, only five cases have been reported in lymphoid malignancies, including acute lymphoblastic leukemia (ALL) (Bacher et al, 2009), diffuse large B-cell lymphoma (Itoyama et al, 2002, Gindina T., table 1, case #3) and follicular lymphoma (Dave t al, 1999; Donti et al., 1988). | ||||||||||||||||||||||||||||||
Epidemiology | Table 1. Reported cases with i(X)(q10).
ALL: acute lymphoblastic leukemia; DLBCL: diffuse large B-cell lymphoma; FL: follicular lymphoma |
Cytogenetics |
![]() | |
Complex karyotype with extra i(X)(q10) in a patient with DLBCL (table 1, #3). | |
Additional anomalies | Additional chromosome anomalies were observed in all five patients. Extra i(X)(q10) was present in 3 patients (Donti et al., 1988; Dave et al, 1999; Gindina et al, case #3). Associated in combination with other isochromosomes in 2 patients (Donti et al, 1988; Gindina, case #3). In all cases, i(X)(q10) is part of a complex karyotype. t(14;18)(q32;q21) was found in 2 cases: 1 FL case and 1 DLBCL (Dave et al, 1999; Itoyama et al, 2002). |
Result of the chromosomal anomaly |
Oncogenesis | The major consequence of this abnormality is loss of several genes on Xp and gain of several genes on Xq, that leads to genetic imbalance. |
To be noted |
Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
Bibliography |
Inverted duplication dup(1)(q32q21) aas sole aberration in lymphoid and myeloid malignancies. |
Bacher U, Schnittger S, Gruneisen A, et al. |
Cancer Genet Cytogenet. 2009;188(2):108-111. |
PMID 19100515 |
Rearrangements of chromosome band 1p36 in non-Hodgkin's lymphoma. |
Dave BJ, Hess MM, Pickering DL, et al. |
Clin Cancer Res. 1999; 5(6):1401-1409. |
PMID 10389925 |
Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation. |
Donti E, Falini B, Giuseppe Pelicci P., et al. |
Leukemia 1988;2(1):41-44. |
PMID 3339903 |
Molecular cytogenetic analysis of genomic instability at the 1q21-22 chromosomal site in B-cell non-Hodgkin lymphoma. |
Itoyama T, Nanjungud G, Chen W, et al.et al. |
Genes Chromosomes Cancer. 2002;35(4):318-328. |
PMID 12378526 |
Citation |
This paper should be referenced as such : |
Tatiana Gindina |
i(X)(q10) in male patients |
Atlas Genet Cytogenet Oncol Haematol. 2018;22(1):22-24. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Anomalies/iXq10MaleID1492.html |
External links |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:24:55 CET 2020 |
For comments and suggestions or contributions, please contact us