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idic(7)(q11.2)

Written2012-03Paul Persad, Cyrus Manavi, Michael Beaty, Wei Wang, Mark J Pettenati
Department of Pathology, Wake Forest Baptist Health, Medical Center Blvd, Winston-Salem, NC, 27157, USA

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Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1582
Note Isodicentric chromosome 7p is a rare chromosomal abnormality characterized by the loss of the majority of chromosome 7q genetic material during recombination and centromeric duplication. In one study, less than 1% of 500 reviewed AML cases with abnormal cytogenetics contained this anomaly.
Other namesIsodicentric 7p
 

Clinics and Pathology

Disease Acute myeloid leukemia (AML)
Note Isodicentric 7p, idic(7)(q11.2) has been reported in elderly patients with AML often as a sole abnormality. In the 4 previously documented cases presence of idic(7)(q11.2) is associated with a favorable response to induction chemotherapy.
Epidemiology Isodicentric 7p, idic(7)(q11.2) is an extremely rare entity with only 4 cases reported in the literature.
Clinics The case of AML with idic(7)(q11.2) was a 66 year-old female with pancytopenia and 82% blasts.
Prognosis The 5 cases of AML with idic(7)(q11.2) have responded favorably to induction chemotherapy. Genes mapped to the short arm of chromosome 7 and known to have oncogenic potential include EGFR, PDGFA, MDR1, T-cell invasion and metastasis inducing locus and aryl hydrocarbon receptor (AHR). The role of these genes in the favorable chemotherapy response is yet to be determined.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

A case of isodicentric 7p as sole abnormality in a patient with acute myeloid leukemia.
Beverstock GC, de Meijer PH, ten Bokkel Huinink D, Pruijt JF, den Ottolander GJ, Wessels HW, Mollevanger P.
Cancer Genet Cytogenet. 1996 Jul 15;89(2):132-5.
PMID 8697419
 
Isodicentric 7p, idic(7)(q11.2), in acute myeloid leukemia associated with older age and favorable response to induction chemotherapy: a new clinical entity?
Johansson B, Axelsson P, Billstrom R, Strombeck B, Arheden K, Olofsson T, Cervin A, Adriansson M, Tanke HJ, Mitelman F, Fioretos T.
Genes Chromosomes Cancer. 2001 Mar;30(3):261-6.
PMID 11170283
 

Citation

This paper should be referenced as such :
Persad, P ; Manavi, C ; Beaty, M ; Wang, W ; Pettenati, MJ
idic(7)(q11.2)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(9):676-676.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/idic7q11ID1582.html


Translocations implicated (Data extracted from papers in the Atlas)

 idic(7)(q11.2)

External links

Mitelman databaseidic(7)(q11.2) [Case List]    idic(7)(q11.2) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaseidic(7)(q11.2)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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