Near haploid acute lymphoblastic leukaemia
1999-06-01 Barbara Gibbons Affiliation1.NE London Regional Cytogenetics Laboratory 2nd Floor, Queen Square House Institute of Neurology Queen Square London WC1N 3BG, UK
Clinics and Pathology
Disease
acute lymphoblastic leukemia (ALL)
Phenotype stem cell origin
B precursor ALL
Epidemiology
a rare type of leukaemia; near-haploid patients tend to be children or teenagers; slight excess of females
Prognosis
generally short complete remission duration and poor prognosis, although long survivors have been reported
Cytogenetics
Cytogenetics morphological
near haploidy is usually defined as 50 hyperdiploid ALL; the distinction is important as near-haploidy defines a rare type of childhood ALL associated with short median complete remission duration and poor prognosis
Additional anomalies
occasional structural chromosome abnormality
Genes Involved and Proteins
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 2779290 | 1989 | Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups. | Callen DF et al |
| 1943226 | 1991 | Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature. | Gibbons B et al |
| 9858226 | 1998 | Near-haploid common acute lymphoblastic leukaemia of childhood with a second hyperdiploid line: a DNA ploidy and fluorescence in-situ hybridization study. | Ma SK et al |
| 1377941 | 1992 | Hyperdiploidy arising from near-haploidy in childhood acute lymphoblastic leukemia. | Onodera N et al |
| 2306521 | 1990 | Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line. | Pui CH et al |
Citation
Barbara Gibbons
Near haploid acute lymphoblastic leukaemia
Atlas Genet Cytogenet Oncol Haematol. 1999-06-01
Online version: http://atlasgeneticsoncology.org/haematological/1145/near-haploid-acute-lymphoblastic-leukaemia
