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Near haploid acute lymphoblastic leukaemia

Written1999-06Barbara Gibbons
NE London Regional Cytogenetics Laboratory 2nd Floor, Queen Square House Institute of Neurology Queen Square London WC1N 3BG, UK

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ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
Atlas_Id 1145

Clinics and Pathology

Disease acute lymphoblastic leukemia (ALL)
Phenotype / cell stem origin B precursor ALL
Epidemiology a rare type of leukaemia; near-haploid patients tend to be children or teenagers; slight excess of females
Prognosis generally short complete remission duration and poor prognosis, although long survivors have been reported


Cytogenetics Morphological near haploidy is usually defined as <30 chromosomes; typically the abnormal clone has 23-28 chromosomes; the pattern of chromosome loss in near-haploidy is not random as there is preferential retention of two copies of chromosomes 6, 8, 10, 14, 18, 21, and the sex chromosomes; in addition to the haploid clone it is common to see a normal diploid clone and a cell line with double the near-haploid number of chromosomes, resulting in hyperdiploidy; occasionally the near-haploid clone is hard to detect resulting in apparent hyperdiploidy; the hyperdiploid cells however tend to have 2 or 4 copies of chromosomes and can thus be distinguished from typical >50 hyperdiploid ALL; the distinction is important as near-haploidy defines a rare type of childhood ALL associated with short median complete remission duration and poor prognosis
Additional anomalies occasional structural chromosome abnormality


Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups.
Callen DF, Raphael K, Michael PM, Garson OM
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 749-752.
PMID 2779290
Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature.
Gibbons B, MacCallum P, Watts E, Rohatiner AZ, Webb D, Katz FE, Secker-Walker LM, Temperley IJ, Harrison CJ, Campbell RH
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1991 ; 5 (9) : 738-743.
PMID 1943226
Near-haploid common acute lymphoblastic leukaemia of childhood with a second hyperdiploid line: a DNA ploidy and fluorescence in-situ hybridization study.
Ma SK, Chan GC, Wan TS, Lam CK, Ha SY, Lau YL, Chan LC
British journal of haematology. 1998 ; 103 (3) : 750-755.
PMID 9858226
Hyperdiploidy arising from near-haploidy in childhood acute lymphoblastic leukemia.
Onodera N, McCabe NR, Nachman JB, Johnson FL, Le Beau MM, Rowley JD, Rubin CM
Genes, chromosomes & cancer. 1992 ; 4 (4) : 331-336.
PMID 1377941
Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line.
Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG
Blood. 1990 ; 75 (5) : 1170-1177.
PMID 2306521


This paper should be referenced as such :
Gibbons, B
Near haploid acute lymphoblastic leukaemia
Atlas Genet Cytogenet Oncol Haematol. 1999;3(3):150-150.
Free journal version : [ pdf ]   [ DOI ]
On line version :

External links

COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
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