Near haploid acute lymphoblastic leukaemia

1999-06-01   Barbara Gibbons 

1.NE London Regional Cytogenetics Laboratory 2nd Floor, Queen Square House Institute of Neurology Queen Square London WC1N 3BG, UK

Clinics and Pathology

Disease

acute lymphoblastic leukemia (ALL)

Phenotype stem cell origin

B precursor ALL

Epidemiology

a rare type of leukaemia; near-haploid patients tend to be children or teenagers; slight excess of females

Prognosis

generally short complete remission duration and poor prognosis, although long survivors have been reported

Cytogenetics

Cytogenetics morphological

near haploidy is usually defined as 50 hyperdiploid ALL; the distinction is important as near-haploidy defines a rare type of childhood ALL associated with short median complete remission duration and poor prognosis

Additional anomalies

occasional structural chromosome abnormality

Bibliography

Pubmed IDLast YearTitleAuthors
27792901989Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups.Callen DF et al
19432261991Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature.Gibbons B et al
98582261998Near-haploid common acute lymphoblastic leukaemia of childhood with a second hyperdiploid line: a DNA ploidy and fluorescence in-situ hybridization study.Ma SK et al
13779411992Hyperdiploidy arising from near-haploidy in childhood acute lymphoblastic leukemia.Onodera N et al
23065211990Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line.Pui CH et al

Citation

Barbara Gibbons

Near haploid acute lymphoblastic leukaemia

Atlas Genet Cytogenet Oncol Haematol. 1999-06-01

Online version: http://atlasgeneticsoncology.org/haematological/1145/near-haploid-acute-lymphoblastic-leukaemia