+X solely in lymphomas

Abstract

Review on +X solely in lymphomas, with data on clinics.

Keywords

X chromosome gain, malignant lymphoma, chronic lymhocytic leukemia, gene downregulation.

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo	C420,C421,C424
ICD-Morpho	9823/3 Chronic lymphocytic leukaemia /small lymphocytic lymphoma
ICD-Morpho	9700/3 Mycosis fungoides
ICD-Morpho	9701/3 Sezary syndrome
ICD-Morpho	9827/3 Adult T-cell leukaemia/lymphoma
ICD-Morpho	9705/3 Angioimmunoblastic T-cell lymphoma
ICD-Morpho	9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS; Primary DLBCL of the CNS; Primary cutaneous DLBCL, leg type; EBV positive DLBCL of the elderly; DLBCL associated with chronic inflammation; B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
ICD-Morpho	9650/3 Classical Hodgkin lymphoma
ICD-Morpho	9663/3 Nodular sclerosis classical Hodgkin lymphoma
ICD-Morpho	9702/3 Peripheral T-cell lymphoma, NOS; Anaplastic large cell lymphoma, ALK negative
ICD-Morpho	9689/3
ICD-Morpho	9673/3 Mantle cell lymphoma
ICD-Morpho	9690/3 Follicular lymphoma; Paediatric follicular lymphoma
Atlas_Id	1800

Clinics and Pathology

Disease	B- and T-cell lymphomas and chronic lymhocytic leukemia (CLL).
Phenotype / cell stem origin	39 lymphoma cases to date; among them, lymphomas with B-cell phenotype in 26 patients: follicular lymphoma (FL, n=6) (Rosenwald et al 1999; Horsman et al 2001; Goodlad et al 2003; Fan & Rizkalla 2003; Rajgopal et al 2003; Aamot et al 2007), diffuse large B-cell lymphomas (DLBCL, n=6) (Koduru et al., 1987; Konishi et al., 1990; Cigudosa et al., 1999; Cerretini et al., 2006; Niitsu et al., 2009; Niitsu et al., 2009); mature B-cell neoplasm (n=3, MBCN) ( Maseki et al., 1987; Coignet et al., 1996; Cook et al., 2004), nodal marginal zone B-cell lymphoma (NMZL, n=3) ( Cook et al., 2004; Aamot et al., 2005; Martin-Subero et al., 2007); splenic marginal zone B-cell lymphoma (SMZL, n=3) (Dierlamm et al., 1996; Le Baccon et al., 2001; Narayan et al., 2013), Hodgkin disease (HD, n=3) (Dennis et al., 1989; Schlegelberger et al., 1994; Falzetti et al., 1999), 1 post-transplant lymphoproliferative disorder with primary non-Hodgkin lymphoma (Djokic et al., 2006) and 1 mantle cell lymphoma case (Siebert et al., 1998). Various T-cell malignancies in 13 patients: most often angioimmunoblastic T-cell lymphoma (ATCL, n=6) (Godde-Salz et al., 1987; Kaneko et al., 1988; Schlegelberger et al., 1990), mature T- and NK-cell neoplasm (n=2) (Hashimoto et al., 1995), mycosis fungoides/Sezary syndrome (n=2) (van Vloten et al., 1979; Limon et al., 1995), adult T-cell lymphoma/leukemia (HTLV-1+) (ATL, n=2) (Sanada et al., 1986; Itoyama et al., 2001) and 1 there was 1 unspecified peripheral T-cell lymphoma case (Schlegelberger et al., 1994) (Table 1).   B>Sex/Age B>Disease B>Karyotype 1 F/75$ Mycosis fungoides/Sezary syndrome 46,XX,dmin/47,XX,+X 2 F/62 Adult T-cell lymphoma/leukemia (HTLV-1+) 46,XX,add(2)(p13),del(3)(q2?1q2?5)/45,X,-X/47,XX,+X 3 M/75 Angioimmunoblastic T-cell lymphoma 47,XY,+X/47,idem,del(10)(p12)          LN 4 F/64 Angioimmunoblastic T-cell lymphoma  47,XX,+X          LN 5 F/73 Diffuse large B-cell lymphoma 47,XX,+X          LN 6 M/82 Mature B-cell neoplasm, NOS 47,XY,+X          LN 7 F/63 Angioimmunoblastic T-cell lymphoma 47,XX,+add(3)(p11)/47,XX,+X          LN 8 M/49 Hodgkin disease, NOS 47,XY,+X          LN 9 M/72 Diffuse large B-cell lymphoma 47,XY,+X          LN 10 F/63 Angioimmunoblastic T-cell lymphoma 49,XX,+5,+19,+21/47,XX,+X/46,XX,inv(14)(q11q32)/45,X,-X          LN 11 F/78 Angioimmunoblastic T-cell lymphoma 47,XX,+X          LN 12 F/47 Angioimmunoblastic T-cell lymphoma 47,XX,+X          LN 13 F/35 Hodgkin disease, nodular sclerosis 78-82,XX,-X,-X,i(1)(q10),add(5)(p?),del(6)(q?)x2,add(7)(q?),del(7) (q?),del (9)(p?),hsr(11)(p?),add(19)(q?),+mar/47,XX,+X          LN 14 F/65 Peripheral T-cell lymphoma, unspecified 47,XX,+X 15 M/54 Mature T- and NK-cell neoplasm, NOS 47,XY,+X/35-42,XY,der(1;13)(q10;q10),der(1;14)(p10;q10)          LN 16 M/78 Mature T- and NK-cell neoplasm, NOS 47,XY,+X          LN 17 F/64 Mycosis fungoides/Sezary syndrome 43-45,XX,del(3)(p11),i(6)(p10),+8,add(10)(q24),del(12)(p11),der(17)t(3;17) (q12;p11),add(19)(q13),+mar,inc/47,XX,+X/41-44,XX,+7,inc 18 F/89 Mature B-cell neoplasm, NOS 47,XX,+12/47,XX,+X          LN 19 F/57 Splenic marginal zone B-cell lymphoma 47,XX,+X          LN 20 F/60 Mantle cell lymphoma 80-88,XXXX,+X,add(1)(q32),del(1)(q24),-4,-6,del(6)(q21q23),-9,-9,t(11;14) (q13;q32),add(12)(q24),-13,-13,der(14)t(11;14),-15,-15,+16, -19,-22,+3mar/47, XX,+X LN 21 F Diffuse large B-cell lymphoma 47,XX,+X          LN 22  F/16 Hodgkin disease, nodular sclerosis 47,XX,+X          LN 23 F Follicular lymphoma 47,XX,+X           LN 24 F/73 Splenic marginal zone B-cell lymphoma 46,XX,dup(1)(?q12?q31),del(7)(q32q36)/47,XX,+X          LN 25 F/32 Adult T-cell lymphoma/leukemia (HTLV-1+) 47,XX,+X/49,XX,+del(3)(p13),+5,+11 26 M/51 Follicular lymphoma 47,XY,+X/49,idem,t(14;18)(q32;q21),+i(18)(q10),+21          LN 27 F/62 Follicular lymphoma 51,XX,+X,+3,del(4)(q31),add(10)(p13),t(14;18)(q32;q21),+18,+21, +r/52,idem, +2/51,idem,add(2)(p23)/47,XX,+X          LN 28 M Follicular lymphoma 47,XY,+X/47-49,idem,+7,t(9;10)(p10;q10),t(14;18)(q32;q21),+21 LN 29 M/51 Follicular lymphoma 47,XX,+X/49-52,XY,+X,+2,+12,t(14;18)(q32;q21),+21,+mar          LN 30 F Nodal marginal zone B-cell lymphoma 48,XX,+3,del(11)(q23),del(13)(q12q14),+18/47,XX,+X          LN 31 M Mature B-cell neoplasm, NOS 47,XY,+X/50,idem,+X,add(1)(p36),trp(1)(q21q32),+add(2)(p23),+der(3;4)(p10;q10),add(6)(p25),+12,der(14;15)(p10;q10)add(14)(q32),+18,i(21)(q10),add(22)(p11),+mar          LN 32 F/75 Nodal marginal zone B-cell lymphoma 47,XX,+X          LN 33 M/36 Diffuse large B-cell lymphoma 47,XY,+X 34 F/40 Post-transplant lymphoproliferative disorder 47,XX,+X          primary non-Hodgkin lymphoma 35 M Follicular lymphoma 47,XY,+X/47,idem,der(1)add(1)(p36)t(1;6)(q32;q13),der(6)t(1;6),del(13)(q31), t(14;18)(q32;q21)          LN 36 F/85 Nodal marginal zone B-cell lymphoma 46,XX,del(1)(q42-43),der(7)t(3;7)(q21;q34-35)/48,idem,del(X)(q23-24),der(3)ins(3;7)(q?24;?),+der(3)t(3;7)(p25;?),t(14;19) (q32;q13),+mar/47,XX,+X          LN 37 M/54 Diffuse large B-cell lymphoma 55,XY,+X,+2,+3,t(8;14)(q24;q32),t(14;18)(q32;q21)/47,XY,+X          LN 38 F/44 Diffuse large B-cell lymphoma 47,XX,+X,t(8;14)(q24;q32),t(14;18)(q32;q21)/47,XX,+X           LN 39 M/50 Splenic marginal zone B-cell lymphoma 47,XY,+X          LN B>Abbreviations: M, male; F, female; LN, lymph node. 1.van Vloten et al., 1979; 2. Sanada et al., 1986; 3-4. Godde-Salz et al., 1987; 5. Koduru et al., 1987; 6. Maseki et al., 1987; 7. Kaneko et al., 1988; 8. Dennis et al., 1989; 9. Konishi et al., 1990; 10-12. Schlegelberger et al., 1990; 13-14. Schlegelberger et al., 1994; 15-16. Hashimoto et al., 1995; 17. Limon et al., 1995; 18. Coignet et al., 1996; 19. Dierlamm et al., 1996; 20. Siebert et al., 1998; 21. Cigudosa et al., 1999; 22.  Falzetti et al., 1999; 23. Rosenwald et al., 1999; 24. Le Baccon et al., 2001; 25. Itoyama et al., 2001; 26. Horsman et al., 2001; 27 Goodlad et al., 2003; 28. Fan & Rizkalla., 2003; 29. Rajgopal et al., 2003; 30-31. Cook et al., 2004; 32. Aamot et al., 2005; 33. Cerretini et al., 2006; 34. Djokic et al., 2006; 35. Aamot et al., 2007; 36. Martin-Subero et al., 2007; 37-38. Niitsu et al., 2009; 39. Narayan et al., 2013. Chronic lymphocytic leukemia was found in 16 patients (Barbieri et al., 1984; Ohtaki et al., 1986; Asou et al., 1994; Arif et al., 1995; Mould et al., 1996; Geisler et al., 1997; Lopez et al., 2012) (Table 2).   Sex/Age Karyotype 1 F/40 47,XX,+X 2 F/59 47,XX,+12/47,XX,+8/47,XX,+16/47,XX,+17/47,XX,+18/47,XX,+X/46,XX,del(6)(q?)/46,XX,del(10)(q?) 3 F 47,XX,+X 4 F/79 47,XX,+X/46,XX,-1,+15 5 F 47,XX,+12/47,idem,del(13)(q12q14)/47,XX,+X 6 F 47,XX,+X 7 F 47,XX,+X 8 F 45,X,-X/47,XX,+X 9 F 46,XX,del(6)(q15q22)/47,XX,+X 10 F 47,XX,+X 11 M 47,XY,+X 12 F 47,XX,+X,inv(9)(p13q12)c 13 M 47,XY,+X 14 M 45,XY,der(8;17)(q10;q10)/46-47,XY,+X 15 F 47,XX,+X 16 F 47,XX,+12/47,XX,+X Figure 2. Clinical and karyotyping data in chronic lymphocytic leukemia patients. 1. Barbieri et al., 1984; 2. Ohtaki et al., 1986; 3. Asou et al., 1994; 4. Arif et al., 1995; 5. Mould et al., 1996; 6-15. Geisler et al., 1997 16. Lopez et al., 2012.
Epidemiology	14 males and 25 females with various forms of lymphomas (aged 16 to 89 years; median age 62 years); median age was 62 years in B-cell lymphomas (11 males and 15 females aged 16 to 89 years); female prevalence in T-cell malignancies (3 males, 10 females aged 32 to 78 years). Similarly, there is a female prevalence in chronic lymphocytic leukemia patients (3 males and 13 females), aged 40 to 79 years (from the known data).
Prognosis	Unknown, due to the heterogeneity of diseases; (indolent versus aggressive disease); patients with only numerical abnormalities may have better outcome than patients with structural changes in a sideline.

Cytogenetics

Cytogenetics Morphological	Out of 39 lymphoma patients, the extra chromosome X was found in a sideline in 22 cases: Found in association with t(8;14)(q24;q32) and t(14;18)(q32;q21) in 1 DLCL (Niitsu et al., 2009), t(14;18)(q32;q21) in 5 FL (Horsman et al., 2001; Goodlad et al., 2003; Fan and Rizkalla., 2003; Rajgopal et al., 2003; Aamot et al., 2007), t(11;14)(q13;q32) in 1 MCL (Siebert et al., 1998), del(11)(q23) and del(13)(q12q14) in 1 NMZL (Cook et al., 2004), t(14;19)(q32;q13) in 1 NMZL (Martin-Subero et al.,2007), t(11;14)(q13;q32) in 1 MCL (Siebert et al., 1998) and miscellaneous anomalies in 4 B-cell lymphomas (Schlegelberger et al., 1994; Coignet et al., 1996; Le Baccon et al., 2001; Cook et al., 2004). Associated withinv(14)(q11q32) in 1 patient with angioimmunoblastic T-cell lymphoma (Schlegelberger et al., 1990) and miscellaneous anomalies in 7 patients with T-cell lymphomas (van Vloten et al., 1979; Sanada et al 1986; Godde-Salz et al., 1987; Kaneko et al., 1988; Hashimoto et al., 1995; Limon et al 1995; Itoyama et al 2001). Found in a sideline in 7 out of 16 CLL patients. Among them: in association with +12 in 3 (Ohtaki et al., 1986; Mould et al., 1996; Lopez et al., 2012), -X in 1 (Geisler et al., 1997), del(6)(q15q22) in 1 (Geisler et al .,1997), der(8;17)(q10;q10) in 1 (Geisler et al., 1997); and -1, +15 in 1 (Arif et al., 1995).
	Figure 1. Partial karyotype showing an extra copy of chromosome X (A). Fluorescence in situ hybridization with centromeric CEP X/Y probe (Abbott Molecular, Vysis, US) showing 3 copies of chromosome X (red signal) in metaphase and interphase cells (B).

Genes involved and Proteins

Note

Whole chromosome gain of an X chromosome has been described in various types of hematological malignancies, including malignant lymphomas. Additional sex chromosomes are usually part of complex karyotypes, representing secondary karyotypic alterations in a significant proportion of lymphomas, and less frequently in CLL. While extra X chromosome is a known numerical abnormality in these diseases, its gain as the sole acquired abnormality is not a common feature. Numerical X chromosome changes are often found in a sideline, indicative of a multistep pathogenesis, where X chromosome gain would likely represent a relatively early genetic event. However, it is unclear whether +X alone is capable of promoting oncogenesis or aberrant effects of the trisomy might allow direct acquisition of cancer-promoting mutations.

Bibliography

G-banding and molecular cytogenetic analyses of marginal zone lymphoma

Aamot HV, Micci F, Holte H, Delabie J, Heim S

Br J Haematol 2005 Sep;130(6):890-901

PMID 16156859

Non-Hodgkin lymphoma with t(14;18): clonal evolution patterns and cytogenetic-pathologic-clinical correlations

Aamot HV, Torlakovic EE, Eide MB, Holte H, Heim S

J Cancer Res Clin Oncol 2007 Jul;133(7):455-70

PMID 17235551

Independent clones of trisomy 12 and retinoblastoma gene deletion in Japanese B cell chronic lymphocytic leukemia, detected by fluorescence in situ hybridization

Arif M, Tanaka K, Asou H, Ohno R, Kamada N

Leukemia 1995 Nov;9(11):1822-7

PMID 7475269

Japanese B cell chronic lymphocytic leukaemia: a cytogenetic and molecular biological study

Asou H, Takechi M, Tanaka K, Tashiro S, Dohy H, Ohno R, Kamada N

Br J Haematol 1993 Nov;85(3):492-7

PMID 8136271

Cytogenetic evaluation of bone marrow involvement in non-Hodgkin's lymphomas

Barbieri D, Michaux JL, Bosly A, van Hove W, Noens L, Drochmans A, Louwagie A, Tricot G, Boogaerts M, Vermaelen K, et al

A survey of 94 cases Haematologica

PMID 6432640

New chromosome abnormalities and lack of BCL-6 gene rearrangements in Argentinean diffuse large B-cell lymphomas

Cerretini R, Noriega MF, Narbaitz M, Slavutsky I

Eur J Haematol 2006 Apr;76(4):284-93

PMID 16519699

Cytogenetic analysis of 363 consecutively ascertained diffuse large B-cell lymphomas

Cigudosa JC, Parsa NZ, Louie DC, Filippa DA, Jhanwar SC, Johansson B, Mitelman F, Chaganti RS

Genes Chromosomes Cancer 1999 Jun;25(2):123-33

PMID 10337996

Automated counting of in situ hybridization dots in interphase cells of leukemia samples

Coignet LJ, Van de Rijke FM, Vrolijk J, Bertheas MF, Raap AK, Tanke HJ

Leukemia 1996 Jun;10(6):1065-71

PMID 8667644

Utility of routine classical cytogenetic studies in the evaluation of suspected lymphomas: results of 279 consecutive lymph node/extranodal tissue biopsies

Cook JR, Shekhter-Levin S, Swerdlow SH

Am J Clin Pathol 2004 Jun;121(6):826-35

PMID 15198354

Cytogenetic studies of Hodgkin's disease

Dennis TR, Stock AD, Winberg CD, Sheibani K, Rappaport H

Analysis of involved lymph nodes from 12 patients Cancer Genet Cytogenet

PMID 2702619

Marginal zone B-cell lymphomas of different sites share similar cytogenetic and morphologic features

Dierlamm J, Pittaluga S, Wlodarska I, Stul M, Thomas J, Boogaerts M, Michaux L, Driessen A, Mecucci C, Cassiman JJ, De Wolf-Peeters C, Van den Berghe H

Blood 1996 Jan 1;87(1):299-307

PMID 8547655

Post-transplant lymphoproliferative disorder subtypes correlate with different recurring chromosomal abnormalities

Djokic M, Le Beau MM, Swinnen LJ, Smith SM, Rubin CM, Anastasi J, Carlson KM

Genes Chromosomes Cancer 2006 Mar;45(3):313-8

PMID 16283619

Genomic instability and recurrent breakpoints are main cytogenetic findings in Hodgkin's disease

Falzetti D, Crescenzi B, Matteuci C, Falini B, Martelli MF, Van Den Berghe H, Mecucci C

Haematologica 1999 Apr;84(4):298-305

PMID 10190942

Comprehensive cytogenetic analysis including multicolor spectral karyotyping and interphase fluorescence in situ hybridization in lymphoma diagnosis

Fan YS, Rizkalla K

a summary of 154 cases Cancer Genet Cytogenet

PMID 12742158

Chromosomal abnormalities in lymphogranulomatosis X (LgrX)/angioimmunoblastic lymphadenopathy (AILD)

Gödde-Salz E, Feller AC, Lennert K

Leuk Res 1987;11(2):181-90

PMID 3821157

In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients

Geisler CH, Philip P, Christensen BE, Hou-Jensen K, Pedersen NT, Jensen OM, Thorling K, Andersen E, Birgens HS, Drivsholm A, Ellegaard J, Larsen JK, Plesner T, Brown P, Andersen PK, Hansen MM

Leuk Res 1997 Nov-Dec;21(11-12):1011-23

PMID 9444933

Follicular lymphoma with marginal zone differentiation: cytogenetic findings in support of a high-risk variant of follicular lymphoma

Goodlad JR, Batstone PJ, Hamilton D, Hollowood K

Histopathology 2003 Mar;42(3):292-8

PMID 12605649

Correlations of chromosome abnormalities with histologic and immunologic characteristics in 49 patients from Akita, Japan with non-Hodgkin lymphoma

Hashimoto K, Miura I, Chyubachi A, Saito M, Miura AB

Cancer Genet Cytogenet 1995 May;81(1):56-65

PMID 7773961

Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18)

Horsman DE, Connors JM, Pantzar T, Gascoyne RD

Genes Chromosomes Cancer 2001 Apr;30(4):375-82

PMID 11241790

Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki

Itoyama T, Chaganti RS, Yamada Y, Tsukasaki K, Atogami S, Nakamura H, Tomonaga M, Ohshima K, Kikuchi M, Sadamori N

Blood 2001 Jun 1;97(11):3612-20

PMID 11369658

Characteristic karyotypic pattern in T-cell lymphoproliferative disorders with reactive "angioimmunoblastic lymphadenopathy with dysproteinemia-type" features

Kaneko Y, Maseki N, Sakurai M, Takayama S, Nanba K, Kikuchi M, Frizzera G

Blood 1988 Aug;72(2):413-21

PMID 3261178

Cytogenetic and histologic correlations in malignant lymphoma

Koduru PR, Filippa DA, Richardson ME, Jhanwar SC, Chaganti SR, Koziner B, Clarkson BD, Lieberman PH, Chaganti RS

Blood 1987 Jan;69(1):97-102

PMID 3790730

Chromosome abnormalities in malignant lymphoma in patients from Kurashiki: histological and immunophenotypic correlations

Konishi H, Sakurai M, Nakao H, Maseki N, Kaneko Y, Yagiri Y, Notohara K, Frizzera G

Cancer Res 1990 May 1;50(9):2698-703

PMID 2328495

Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations

López C, Delgado J, Costa D, Conde L, Ghita G, Villamor N, Navarro A, Cazorla M, Gómez C, Arias A, Muñoz C, Baumann T, Rozman M, Aymerich M, Colomer D, Cobo F, Campo E, López-Guillermo A, Montserrat E, Carrió A

Genes Chromosomes Cancer 2012 Sep;51(9):881-9

PMID 22619094

Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma

Le Baccon P, Leroux D, Dascalescu C, Duley S, Marais D, Esmenjaud E, Sotto JJ, Callanan M

Genes Chromosomes Cancer 2001 Nov;32(3):250-64

PMID 11579465

Chromosome aberrations, spontaneous SCE, and growth kinetics in PHA-stimulated lymphocytes of five cases with Sézary syndrome

Limon J, Nedoszytko B, Brozek I, Hellmann A, Zajaczek S, Lubiński J, Mrózek K

Cancer Genet Cytogenet 1995 Aug;83(1):75-81

PMID 7656210

A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation

Martín-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F, Calasanz MJ, De Wolf-Peeters C, Dyer MJ, Felman P, Gardiner A, Gascoyne RD, Gesk S, Harder L, Horsman DE, Kneba M, Küppers R, Majid A, Parry-Jones N, Ritgen M, Salido M, Solé F, Thiel G, Wacker HH, Oscier D, Wlodarska I, Siebert R

Leukemia 2007 Jul;21(7):1532-44

PMID 17495977

Chromosome abnormalities in malignant lymphoma in patients from Saitama

Maseki N, Kaneko Y, Sakurai M, Kurihara M, Sampi K, Shimamura K, Takayama S

Cancer Res 1987 Dec 15;47(24 Pt 1):6767-75

PMID 3315191

PCDH10 promoter hypermethylation is frequent in most histologic subtypes of mature lymphoid malignancies and occurs early in lymphomagenesis

Narayan G, Xie D, Freddy AJ, Ishdorj G, Do C, Satwani P, Liyanage H, Clark L, Kisselev S, Nandula SV, Scotto L, Alobeid B, Savage D, Tycko B, O'Connor OA, Bhagat G, Murty VV

Genes Chromosomes Cancer 2013 Nov;52(11):1030-41

PMID 23929756

Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations

Niitsu N, Okamoto M, Miura I, Hirano M

Leukemia 2009 Apr;23(4):777-83

PMID 19151788

Sequential chromosome abnormalities in B cell chronic lymphocytic leukemia: a study of 13 cases

Ohtaki K, Han T, Sandberg AA

Cancer Genet Cytogenet 1986 Feb 1;20(1-2):73-87

PMID 3484671

A lineage-specific t(1;14)(q21;q32) as an early event in development of B-cell clonal expansion

Pinkerton PH, Reis MD, DeCoteau J, Srigley JR, Dubé ID, London B

Cancer Genet Cytogenet 1992 Dec;64(2):166-9

PMID 1486567

Detection by fluorescence in situ hybridization of microdeletions at 1p36 in lymphomas, unidentified on cytogenetic analysis

Rajgopal A, Carr IM, Leek JP, Hodge D, Bell SM, Roberts P, Horgan K, Bonthron DT, Selby PJ, Markham AF, MacLennan KA

Cancer Genet Cytogenet 2003 Apr 1;142(1):46-50

PMID 12660032

A biological role for deletions in chromosomal band 13q14 in mantle cell and peripheral t-cell lymphomas? Genes Chromosomes Cancer

Rosenwald A, Ott G, Krumdiek AK, Dreyling MH, Katzenberger T, Kalla J, Roth S, Ott MM, Müller-Hermelink HK

1999 Nov;26(3):210-4

PMID 10502318

Chromosomal abnormalities in a patient with smoldering adult T-cell leukemia: evidence for a multistep pathogenesis

Sanada I, Nakada K, Furugen S, Kumagai E, Yamaguchi K, Yoshida M, Takatsuki K

Leuk Res 1986;10(12):1377-82

PMID 2879073

Recurrent chromosome abnormalities in peripheral T-cell lymphomas

Schlegelberger B, Himmler A, Bartles H, Kuse R, Sterry W, Grote W

Cancer Genet Cytogenet 1994 Nov;78(1):15-22

PMID 7987800

Application of interphase cytogenetics for the detection of t(11;14)(q13;q32) in mantle cell lymphomas

Siebert R, Matthiesen P, Harder S, Zhang Y, Borowski A, Zühlke-Jenisch R, Plendl H, Metzke S, Joos S, Zucca E, Weber-Matthiesen K, Roggero E, Grote W, Schlegelberger B

Ann Oncol 1998 May;9(5):519-26

PMID 9653493

Chromosome studies in mycosis fungoides

van Vloten WA, Pet EA, Geraedts JP

Br J Dermatol 1980 May;102(5):507-13

PMID 7387897

Citation

This paper should be referenced as such :

Adriana Zamecnikova

+X solely in lymphomas

Atlas Genet Cytogenet Oncol Haematol. 2018;22(9):382-387.

Free journal version : [ pdf ]   [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Anomalies/plusXID1800.html

External links

arrayMap (UZH-SIB Zurich)	Morph ( 9823/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9700/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9701/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9827/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9705/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9680/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9650/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9663/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9702/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9689/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9673/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)	Morph ( 9690/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Sep 7 15:06:57 CEST 2020

For comments and suggestions or contributions, please contact us