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12p rearrangements in CLL

Written2005-07Kavita S Reddy
Genzyme Genetics, 1054 Town, Country Road, Orange, CA 92868, USA

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2023

Clinics and Pathology

Disease Chronic lymphoproliferative leukemia (CLL)
Epidemiology A 12p rearrangement is observed in about 1.4% CLL cases usually as part of a complex karyotype with multiple abnormalities, but about 7.7% of these are apparently sole cytogenetic abnormality.
Prognosis 12p rearrangements in CLL probably are early chromosome defects that are not associated with the classical DNA gains and losses known to be present in the majority of CLL. An atypical morphology and immunophenotype may be present in cases with 12p rearrangements; and frequently there is disease progression.
Transformation of CLL to PLL has been observed in cases with a 12p abnormality.

Cytogenetics

Cytogenetics Morphological Aberrations of 12p in CLL are often subtle addition to 12p (n=15), followed by translocation (n=12), deletion (n=10), derivative (n=8), dicentric (n=3), inversion (n=2), and isochromosome (n=1). The breakpoint is commonly 12p13 in 31 cases (especially, in almost all del 12p cases), 12p12 in 7 cases, 12p11 in 10 cases, and 12p10 in 1 case.

The recurring 12p rearrangements in CLL are: 5 translocations involving chromosomes 12 and 13, making it the most common recurring 12p translocation. In two of the five cases translocation, t(12;13) is the sole cytogenetic abnormality, but the breakpoints are different, t(12;13)(p13;q22) and t(12;13)(p11;q14). Translocation, t(12;13) has also been found in patients with chronic myelogenous leukemia (CML) in transformation, myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), B and T- acute lymphocytic leukemias (ALL). The t(12;13) is heterogeneous at the molecular level. A single case of AML has been reported with an ETV6-CDX2 fusion and ectopic expression of normal CDX2 but two other t(12;13) positive AML patients did not have CDX2 involvement. FISH analysis has suggested that the chromosome 13 breakpoints are different in myeloid and lymphoid disease. ETV6 seems to be involved in some cases but not others.

The other recurring translocation in CLL involved chromosomes 12 and 17 in 3 cases, 1 a translocation and 2 are derivative 12 resulting from a translocation between 12 and 17 chromosomes. This translocation is observed in patients with acute leukemia at diagnosis or relapse and who had a poor prognosis .

Though, t(12;22)(p13;q11) is a consistent myeloid change there are at least 3 CLL cases with this translocation and one with ETV6 gene deletion. One case of CLL had a t(9;12)(q34;p11) as the sole abnormality, the breakpoint on chromosome 9 coincided with that observed in 6 other cases with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) while the 12 breakpoint 12p13 was different. Two different fusion breakpoints are described; ETV6 exon 4 fused in frame to ABL exon 2 (Type A) and ETV6 exon 5 fused in frame to ABL exon 2 (Type B); ETV6 maintains the HLH domain and ABL the tyrosine kinase domain. Characterization of the 12p breakpoint of 12p rearrangements in lymphoid and myeloid malignancy in context to ETV expression may throw light on the lineage specificity of these rearrangements and their role in the malignancy.

Other translocations of 12p observed in single CLL cases are der(12) t(12;18)(p13;q24), der(12) t(12;12)(p13;q13), der(12)t(1;12)(q11;p12), der(12)t(10;12) (q11;p13), der(12)t(7;12)(p13;p13), der(12)t(12;15)(p12;q13-15), t(5;12;19)(q15;p11;q13), t(6;12)(p21;p13), t(6;10;12)(q15;q22;p13), t(12;14)(p13;q21), dic(9;12)(p24;p13), dic(12;15)(p13;p11) and dic(3;12)(p21;p13)
The inv(12) in 3 cases, is supernumerary in two cases +inv(12)(p13q24) and inv(12)(p13q13)x2, and ?inv(12)(p11q23) in one case.

Summary of 12p rea in CLL

Breakpoint : -

  • 46,XY,?t(4;11)(q?;q?),del(6)(q21q23),del(11)(q?),?del(12)(p?)
  • 45,XY,del(7)(q31),-11,add(12)(p?)/46,idem,+6,del(6)(q?)x2/44,XY,der(3;4) (p10;q10)
  • 46,XY,add(12)(p?),del(13)(q?),del(17)(q?)

    Breakpoint : 12p10

  • 47,XX,i(12)(p10),+i(12)(q10),del(14)(q24)

    Breakpoint : 12p11

  • 48,XY,+3,+del(5)(q15),t(5;12;19)(q15;p11;q13),del(7)(q11)
  • 44,XX,-3,add(12)(p11),der(17;18)(q10;q10)/44,idem,der(17)t(3;17) (p11;p13)ins(17;?)(p13;?)/45,XY,add(3)(p11),der(17;18)
  • 43-46,X,-Y,del(2)(p23),del(6)(q21),del(7)(q32),del(11)(q21),-12,+t(12;17) (p11;q11),t(14;14)(q11;q32),-17,-18
  • 47,XY,+12,t(12;13)(p11;q14)
  • 46,XX,t(12;13)(p11;q14)
  • 46,XY,t(2;8)(p11;q24),t(14;18)(q32;q21)/47,idem,-t(2;8),add(12)(p11),-13, der(17)t(13;17)(q14-21;q23-25),del(19)(p13),+2mar
  • 46,XX,+del(7)(q22),t(11;11)(p13;p15),del(12)(p11),add(13)(p13),-18
  • 46,XY,t(9;12)(q34;p11)
  • 46,XY,t(3;4)(q28;q31),del(11)(q14q24)/92,idemx2/46,idem,del(13)(q12q14)/46, XY,del(6)(?q21q24),del(11)(q22q25),del(13),t(13;16)(q?21;p11)/46,XY,del(6), t(13;16),der(17)t(17;18)(p11;q11)/46,XY,inv(3)(p14q?27),del(4)(q31),del(11) (q14q24),?inv(12)(p11q23)

    Breakpoint : 12p12

  • 45,XX,dic(2;17)(q37;p11),der(12)t(12;17)(p12;q11),del(13)(q14q31)/45,idem, add(19)(p1?3)
  • 46,XX,-7,der(12)t(12;17)(p12;q11),der(15)t(7;15)(q11;q26),der(17)del(17) (p11)t(12;17)(?;p11),add(18)(p11)/47,idem,+12,-add(18)/45,idem,der(3)t (3;15)(p21;q15),+7,der(8)t(8;22)(p11;q11),-15,-der(15),-add(18),-22/46,XX, +12,add(17)(p11),-20,-21,+mar
  • 46,XX,t(12;13)(p12;q14),inc
  • 46,XY,+der(12)t(12;15)(p12;q13-15),der(14;17)(q10;q10)/46,idem,add(1)(q21)
  • ??,XY,del(1)(q?),t(1;10)(q11;p1?5),der(12)t(1;12)(q11;p12)
  • 43,X,add(X)(q28),-1,+2,-7,-9,add(9)(q34),del(10)(q24),-11,add(12)(p12),-21, +mar
  • 46,XY,del(4)(q21q33),del(6)(q23q25),add(12)(p12)

    Breakpoint : 12p13

  • 44,XX,-6,dic(9;12)(p24;p13),der(17)t(6;17)(q15;p13)
  • 43,XY,t(1;14)(p32;q32),-4,t(6;12)(q21;p13),add(7)(p22),-9,-11,add(13)(q34), add(17)(p13)
  • 45,XX,ins(1;?)(q11;?),del(6)(q23),add(7)(q36),add(12)(p13),t(13;15)(q?;q?), add(14)(q32)
  • 46,XY,del(6)(q15q25)/45,idem,der(12;17)t(12;17)(q15;p11)t(12;18)(p13;q24), der(18)t(12;18)(q21;q23)
  • 44,XX,add(9)(q34),add(11)(p15),dic(12;15)(p13;p11),dic(17;18)(p11;p11)
  • 47,XX,add(12)(p13),+der(12)t(12;22)(p13;q11),del(22)(q11)/47,idem,del(9) (p21) Tel deletion
  • 47,XY,+add(12)(p12)
  • 46,XY,add(12)(p13)
  • 47-48,XX,add(12)(p13),+2mar
  • 46,XX,-3,dic(3;12)(p21;p13),der(6)add(6)(p25)del(6)(q16q22),i(8)(q10),del (11)(q14q24)
  • 44,XY,-3,der(8;17)(q10;q10),add(12)(p13),der(12;?)dic(12;?)(p1?1;?)hsr(?), -15,add(15)(p11),+mar
  • 46,XX,del(11)(q13q23),del(12)(p?13),add(17)(q25)
  • 47,XY,+inv(12)(p13q24)
  • 46,XY,del(6)(q23q27),t(12;14)(p13;q21)/46,idem,del(7)(q32q36)/46,XY,t(1;9) (p36;q22)/46,XY,del(6)(q15q26)/46,XY,del(17)(p11)/46,XY,t(6;12)(p22;q13)/46, XY,add(7)(q35)
  • 44-45,XY,add(1)(q23),del(1)(q21),-8,-11,+add(12)(p13),-13,der(14)t(11;14) (q23;q32),-21,+2mar
  • 47,XX,+12,t(12;22)(p13;q11),t(14;19)
  • 82,XXY,-Y,-6,-6,-7,-8,-8,-9,-10,t(11;14)(q13;q32),add(12)(p13)x2,t(13;14) (q11;q32),-14,-17,-18,-19,-20,-22,+4mar
  • 44-46,XY,del(1)(q42),t(2;13)(p21-23;q14),dup(3)(?q27q29),del(6)(p23p25),-9, -11,t(11;14),der(12)qdp(12)(q13q15)trp(12)(q21q22)t(12;12)(p13;q13),-15,-17, +5mar
  • 46,XY,der(1)del(1)(p11p21)del(1)(q22q25),del(2)(q31),del(6)(q13-15),t (11;14)(q13;q32),+12,inv(12)(p13q13)x2
  • 46,XX,add(3)(q21)/46,idem,del(12)(p13),t(?13;14)(q22;q32),del(18)(q21)
  • 46,XX,del(1)(q32),add(11)(p14-15),del(12)(p13)
  • 46,XX,del(1)(q21)/46,XX,t(?13;14)(q22;q32)/46,XX,del(12)(p13),t(?13;14),add (17)(q25)
  • 46,XX,-9,+del(12)(p13),t(?13;14)(q22;q32)/46,XX,del(1)(q32),del(3)(p25),-9, +del(12),t(?13;14),add(16)(p13)
  • 46,XY,del(12)(p13),add(17)(p13)
  • 47,XY,add(1)(p?),del(3)(p2?),add(11)(p14),+13/47,idem,del(11)(q21),del(12) (p13),del(13)(q22),add(14)(q32)
  • 46,XX,r(4)(p16q31),t(4;6)(q31;q26),-10,t(10;12)(q24;q22),add(12)(p13),del (14)(q21),+mar
  • 48,XY,+der(3)del(3)(p?25)del(3)(q?21),t(11;14)(q13;q32),+der(12)t(10;12) (q11;p13)
  • 46,XY,del(12)(p13)
  • 46,XY,add(1)(p36),del(6)(q15),t(6;10;12)(q15;q22;p13),t(11;14)(q13;q32),del (12)(p?),+der(12)t(7;12)(p13;p13)

    TOTAL :

  • 12p13=31, 12p12=7, 12p11=10, 12p10=1
  • add=15, der=8, del =10, t=12, inv=2, i=1, dic=3
  • Bibliography

    Cytogenetic and immunologic characterization of mitotic cells in chronic lymphocytic leukaemia.
    Autio K, Elonen E, Teerenhovi L, Knuutila S
    European journal of haematology. 1987 ; 39 (4) : 289-298.
    PMID 3691755
     
    Chromosome abnormalities in B cell chronic lymphocytic leukemia and their clinical correlations.
    Bird ML, Ueshima Y, Rowley JD, Haren JM, Vardiman JW
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (3) : 182-191.
    PMID 2918755
     
    Nonrandom chromosome abnormalities in lymphoma.
    Bloomfield CD, Arthur DC, Frizzera G, Levine EG, Peterson BA, Gajl-Peczalska KJ
    Cancer research. 1983 ; 43 (6) : 2975-2984.
    PMID 6850608
     
    Translocations involving the short arm of chromosome 17 in chronic B-lymphoid disorders: frequent occurrence of dicentric rearrangements and possible association with adverse outcome.
    Callet-Bauchu E, Salles G, Gazzo S, Poncet C, Morel D, Pagès J, Coiffier B, Coeur P, Felman P
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1999 ; 13 (3) : 460-468.
    PMID 10086737
     
    Structural aberrations of chromosomes 17 and 12 in chronic B-cell disorders.
    Cerretini R, Chena C, Giere I, Sarmiento M, Arrossagaray G, Rodríguez A, Pérez Bianco R, de Dios Soler M, Narbaitz M, Slavutsky I
    European journal of haematology. 2003 ; 71 (6) : 433-438.
    PMID 14703693
     
    Two unbalanced translocations, t(12;22)(p13;q11) and t(12;?)(p13;?), in an aggressive chronic B-cell leukemia: TEL gene analysis using FISH.
    Conchon M, McManus AP, Min T, Maljaie SH, Crawford A, Brito-Babapulle V, Matutes E, Catovsky D
    Cancer genetics and cytogenetics. 1997 ; 95 (2) : 137-140.
    PMID 9169030
     
    Four novel non-random chromosome rearrangements in B-cell chronic lymphocytic leukaemia: 6p24-25 and 12p12-13 translocations, 4q21 anomalies and monosomy 21.
    Cuneo A, Roberti MG, Bigoni R, Minotto C, Bardi A, Milani R, Tieghi A, Campioni D, Cavazzini F, De Angeli C, Negrini M, Castoldi G
    British journal of haematology. 2000 ; 108 (3) : 559-564.
    PMID 10759714
     
    p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias.
    Döhner H, Fischer K, Bentz M, Hansen K, Benner A, Cabot G, Diehl D, Schlenk R, Coy J, Stilgenbauer S
    Blood. 1995 ; 85 (6) : 1580-1589.
    PMID 7888675
     
    FISH identifies different types of duplications with 12q13-15 as the commonly involved segment in B-cell lymphoproliferative malignancies characterized by partial trisomy 12.
    Dierlamm J, Wlodarska I, Michaux L, Vermeesch JR, Meeus P, Stul M, Criel A, Verhoef G, Thomas J, Delannoy A, Louwagie A, Cassiman JJ, Mecucci C, Hagemeijer A, Van den Berghe H
    Genes, chromosomes & cancer. 1997 ; 20 (2) : 155-166.
    PMID 9331566
     
    Karyotypic evolution in CLL: identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease.
    Fegan C, Robinson H, Thompson P, Whittaker JA, White D
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1995 ; 9 (12) : 2003-2008.
    PMID 8609709
     
    Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients.
    Finn WG, Kay NE, Kroft SH, Church S, Peterson LC
    American journal of hematology. 1998 ; 59 (3) : 223-229.
    PMID 9798660
     
    Chromosomal characteristics of malignant lymphoma.
    Fleischman EW, Prigogina EL, Ilynskaya GW, Probatova NA, Konstantinova LN, Kruglova GV, Volkova MA, Osmanov DS
    Human genetics. 1989 ; 82 (4) : 343-348.
    PMID 2737667
     
    Cytogenetic, fluorescence in situ hybridisation, and clinical evaluation of translocations with concomitant deletion at 13q14 in chronic lymphocytic leukaemia.
    Gardiner AC, Corcoran MM, Oscier DG
    Genes, chromosomes & cancer. 1997 ; 20 (1) : 73-81.
    PMID 9290957
     
    In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients.
    Geisler CH, Philip P, Christensen BE, Hou-Jensen K, Pedersen NT, Jensen OM, Thorling K, Andersen E, Birgens HS, Drivsholm A, Ellegaard J, Larsen JK, Plesner T, Brown P, Andersen PK, Hansen MM
    Leukemia research. 1997 ; 21 (11-12) : 1011-1023.
    PMID 9444933
     
    Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.
    Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK
    Blood. 1999 ; 94 (6) : 1848-1854.
    PMID 10477713
     
    The consistent 13q14 translocation breakpoint seen in chronic B-cell leukaemia (BCLL) involves deletion of the D13S25 locus which lies distal to the retinoblastoma predisposition gene.
    Hawthorn LA, Chapman R, Oscier D, Cowell JK
    Oncogene. 1993 ; 8 (6) : 1415-1419.
    PMID 8502470
     
    Karyotypes of 33 patients with clonal aberrations in chronic lymphocytic leukaemia. Review of 216 abnormal karyotypes in chronic lymphocytic leukaemia.
    Huret JL, Mossafa H, Brizard A, Dreyfus B, Guilhot F, Xue XQ, Babin P, Tanzer J
    Annales de genetique. 1989 ; 32 (3) : 155-159.
    PMID 2817776
     
    [Two cases of acute leukemia with t(6;9) (p23;q34)]
    Ito T, Suyama K, Tsukahara R, Matsuoka H, Yokose N, Miyake K, An E, Futaki M, Inokuchi K, Ogata K
    [Rinsho ketsueki] The Japanese journal of clinical hematology. 1993 ; 34 (1) : 50-56.
    PMID 8450608
     
    Loss of genetic material from the short arm of chromosome 12 is a frequent secondary abnormality in non-Hodgkin's lymphoma.
    Jonveaux P, Le Coniat M, Derré J, Vecchione D, Berger R
    Hematologic pathology. 1991 ; 5 (1) : 21-26.
    PMID 2050601
     
    Serial phenotypic, cytogenetic and molecular genetic studies in Richter's syndrome: demonstration of lymphoma development from the chronic lymphocytic leukaemia cells.
    Koduru PR, Lichtman SM, Smilari TF, Sun T, Goh JC, Karp L, Hall W, Hashimoto S, Chiorazzi N, Broome JD
    British journal of haematology. 1993 ; 85 (3) : 613-616.
    PMID 8136284
     
    Complex chromosomal aberrations in chronic lymphocytic leukemia are associated with cellular drug and irradiation resistance.
    Koski T, Karhu R, Visakorpi T, Vilpo L, Knuutila S, Vilpo J
    European journal of haematology. 2000 ; 65 (1) : 32-39.
    PMID 10914937
     
    Sequential karyotypes in non-Hodgkin lymphoma: their nature and significance.
    Levine EG, Juneja S, Arthur D, Garson OM, Machnicki JL, Frizzera G, Ironside P, Cooper I, Hurd DD, Peterson BA
    Genes, chromosomes & cancer. 1990 ; 1 (4) : 270-280.
    PMID 2278958
     
    Translocation (12;17)(p11-12;q11-12): a recurrent primary rearrangement in acute leukemia.
    Liu HW, Wan SK, Ching LM, Liang R, Chan LC
    Cancer genetics and cytogenetics. 1992 ; 64 (1) : 27-29.
    PMID 1458446
     
    Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study.
    Losada AP, Wessman M, Tiainen M, Hopman AH, Willard HF, Solé F, Caballín MR, Woessner S, Knuutila S
    Blood. 1991 ; 78 (3) : 775-779.
    PMID 1859890
     
    Amplification of multiple regions of chromosome 12, including 12q13-15, in chronic lymphocytic leukaemia.
    Merup M, Juliusson G, Wu X, Jansson M, Stellan B, Rasool O, Röijer E, Stenman G, Gahrton G, Einhorn S
    European journal of haematology. 1997 ; 58 (3) : 174-180.
    PMID 9150711
     
    Abnormalities of chromosome no. 1 related to blood dyscrasias: study of 10 cases.
    Miyamoto K, Hamasaki K, Kitajima K, Adachi T, Tanaka T, Sato J
    Acta medica Okayama. 1981 ; 35 (2) : 137-141.
    PMID 6456645
     
    PHA/IL2: an efficient mitogen cocktail for cytogenetic studies of non-Hodgkin lymphoma and chronic lymphocytic leukemia.
    Morgan R, Chen Z, Richkind K, Roherty S, Velasco J, Sandberg AA
    Cancer genetics and cytogenetics. 1999 ; 109 (2) : 134-137.
    PMID 10087947
     
    The most common chromosome change in 86 chronic B cell or T cell tumors: a 14q32 translocation.
    Nowell PC, Vonderheid EC, Besa E, Hoxie JA, Moreau L, Finan JB
    Cancer genetics and cytogenetics. 1986 ; 19 (3-4) : 219-227.
    PMID 3484667
     
    Identification of new translocations involving ETV6 in hematologic malignancies by fluorescence in situ hybridization and spectral karyotyping.
    Odero MD, Carlson K, Calasanz MJ, Lahortiga I, Chinwalla V, Rowley JD
    Genes, chromosomes & cancer. 2001 ; 31 (2) : 134-142.
    PMID 11319801
     
    Del (7)(q32) is associated with a subset of small lymphocytic lymphoma with plasmacytoid features.
    Offit K, Louie DC, Parsa NZ, Noy A, Chaganti RS
    Blood. 1995 ; 86 (6) : 2365-2370.
    PMID 7662983
     
    Frequent clonal abnormalities of chromosome band 13q14 in B-cell chronic lymphocytic leukemia: multiple clones, subclones, and nonclonal alterations in 82 midwestern patients.
    Peterson LC, Lindquist LL, Church S, Kay NE
    Genes, chromosomes & cancer. 1992 ; 4 (4) : 273-280.
    PMID 1377933
     
    Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia.
    Pittman S, Catovsky D
    British journal of haematology. 1984 ; 58 (4) : 649-660.
    PMID 6335048
     
    Mature B-cell leukemias with more than 55% prolymphocytes. A heterogeneous group that includes an unusual variant of mantle cell lymphoma.
    Schlette E, Bueso-Ramos C, Giles F, Glassman A, Hayes K, Medeiros LJ
    American journal of clinical pathology. 2001 ; 115 (4) : 571-581.
    PMID 11293906
     
    Cytogenetic studies in seventy-six cases of B-chronic lymphoproliferative disorders.
    Solé F, Woessner S, Pérez-Losada A, Florensa L, Montero S, Asensio A, Besses C, Sans-Sabrafen J
    Cancer genetics and cytogenetics. 1997 ; 93 (2) : 160-166.
    PMID 9078302
     
    Recurrent abnormalities of chromosome bands 10q23-25 in non-Hodgkin's lymphoma.
    Speaks SL, Sanger WG, Masih AS, Harrington DS, Hess M, Armitage JO
    Genes, chromosomes & cancer. 1992 ; 5 (3) : 239-243.
    PMID 1384677
     
    Detection of 14q32.33 translocation and t(11;14) in interphase nuclei of chronic B-cell leukemia/lymphomas by in situ hybridization.
    Takashima T, Itoh M, Ueda Y, Nishida K, Tamaki T, Misawa S, Abe T, Seto M, Machii T, Taniwaki M
    International journal of cancer. Journal international du cancer. 1997 ; 72 (1) : 31-38.
    PMID 9212219
     
    Trisomy 12 resulting from isochromosomes of both 12p and 12q in a case of B-CLL.
    Van Kessel AG, Stellink F, Janssen I, Schaap N
    Cancer genetics and cytogenetics. 1999 ; 108 (1) : 85-86.
    PMID 9973932
     
    c-myc and K-ras-2 oncogenes in B-cell chronic lymphocytic leukemia with del(12)(p13).
    Wang TY, Samples DM, Dabdoub R, Prakash O
    Cancer genetics and cytogenetics. 1991 ; 51 (1) : 125-130.
    PMID 1984840
     
    Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma.
    Yunis JJ, Oken MM, Theologides A, Howe RB, Kaplan ME
    Cancer genetics and cytogenetics. 1984 ; 13 (1) : 17-28.
    PMID 6467179
     

    Citation

    This paper should be referenced as such :
    Reddy, KS
    12p rearrangements in CLL
    Atlas Genet Cytogenet Oncol Haematol. 2005;9(4):323-326.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Anomalies/rear12pCLLID2023.html


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