Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(1;2)(q12;q37) in acute leukemias

Written2000-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Updated2014-11Shen Yueyang , Gillan Tanya, Héléne Bruyère
Cytogenetics Laboratory, Department of Pathology, Laboratory Medicine, Vancouver, BC, Canada.

Abstract Review on t(1;2)(q12;q37), with data on clinics.

Keywords Acute leukemia ; t(1;2)(q12;q37)

(Note : for Links provided by Atlas : click)


ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1317
Note Only a few cases reported to date, poorly known
  G-band analysis - partial karyotype showing der(2)t(1;2)(q12;q37) Courtesy Drs. Tanya Gillan and Hŕ Bruyè, Vancouver General Hospital Cytogenetics Laboratory

Clinics and Pathology

Disease Acute leukemias
Phenotype / cell stem origin 1 case of M0 acute myeloid leukemia (AML), 1 case of M4 AML, 1 case of M5 AML with monocytic/monoblastic differentiation and 1 case of L1 acute lymphoblastic leukemia (ALL).
Epidemiology a 76 yr old female patient, a 81 yr old male patient, a 31 yr old male patient and a 69 yr old male patient (ALL). A t(1;2)(q12;q37 has also been found in myelodysplastic syndrome (RAEB), 2 multiple myeloma cases, and 2 hepatoblastoma cases.
Prognosis Unknown


Cytogenetics Morphological The t(1;2) was balanced in one case and presented as a der(2)t(1;2) in 3 of the 4 cases, resulting in trisomy 1q. The t(1;2) is likely to be a secondary anomaly. The karyotypes were complex in all cases; the t(1;2) was associated with a t(9;22) in one AML case and in the ALL case. In 3 of the 4 cases, the breakpoint on chromosome 1 was localized in the satellite II domain.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations.
Busson-Le Coniat M, Salomon-Nguyen F, Dastugue N, Maarek O, Lafage-Pochitaloff M, Mozziconacci MJ, Baranger L, Brizard F, Radford I, Jeanpierre M, Bernard OA, Berger R
Leukemia 1999; 13 (12) : 1975-1981.
PMID 10602418
Prognostic Implications of Morphology and Karyotype in Primary Myelodysplastic Syndromes
Jacobs RH, Cornbleet MA, Vardiman JW, Larson RA, Le Beau MM, Rowley JD
Blood. 1986; 67(6): 1765-1772.
PMID 3708160
Hypodiploidy is a major prognostic factor in multiple myeloma
Smadja NV, Bastard C, Brigaudeau C, Leroux D, Fruchart C
Blood. 2001; 98(7): 2229-2238
PMID 11568011
Cytogenetic evaluation of large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-21
Tomlinson GE, Douglass EC, Pollock BH, Finegold MJ, Schneider NR
Genes, Chromosomes Cancer. 2005; 44(2):177-184
PMID 3708160


This paper should be referenced as such :
Shen Yueyang, Gillan Tanya, Hlne Bruyre
t(1;2)(q12;q37) in acute leukemias
Atlas Genet Cytogenet Oncol Haematol. 2015;19(10):628-629.
Free journal version : [ pdf ]   [ DOI ]
On line version :
History of this paper:
Huret, JL. t(1;2)(q12;q37). Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):31-31.

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databaset(1;2)(q12;q37) [Case List]    t(1;2)(q12;q37) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 12 16:59:37 CEST 2019

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us