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t(1;2)(q12;q37) in acute leukemias

Written2000-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Updated2014-11Shen Yueyang , Gillan Tanya, Héléne Bruyère
Cytogenetics Laboratory, Department of Pathology, Laboratory Medicine, Vancouver, BC, Canada. helene.bruyere@vch.ca

Abstract Review on t(1;2)(q12;q37), with data on clinics.

Keywords Acute leukemia ; t(1;2)(q12;q37)

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1317
Note Only a few cases reported to date, poorly known
 
  G-band analysis - partial karyotype showing der(2)t(1;2)(q12;q37) Courtesy Drs. Tanya Gillan and Hŕ Bruyè, Vancouver General Hospital Cytogenetics Laboratory

Clinics and Pathology

Disease Acute leukemias
Phenotype / cell stem origin 1 case of M0 acute myeloid leukemia (AML), 1 case of M4 AML, 1 case of M5 AML with monocytic/monoblastic differentiation and 1 case of L1 acute lymphoblastic leukemia (ALL).
Epidemiology a 76 yr old female patient, a 81 yr old male patient, a 31 yr old male patient and a 69 yr old male patient (ALL). A t(1;2)(q12;q37 has also been found in myelodysplastic syndrome (RAEB), 2 multiple myeloma cases, and 2 hepatoblastoma cases.
Prognosis Unknown

Cytogenetics

Cytogenetics Morphological The t(1;2) was balanced in one case and presented as a der(2)t(1;2) in 3 of the 4 cases, resulting in trisomy 1q. The t(1;2) is likely to be a secondary anomaly. The karyotypes were complex in all cases; the t(1;2) was associated with a t(9;22) in one AML case and in the ALL case. In 3 of the 4 cases, the breakpoint on chromosome 1 was localized in the satellite II domain.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations.
Busson-Le Coniat M, Salomon-Nguyen F, Dastugue N, Maarek O, Lafage-Pochitaloff M, Mozziconacci MJ, Baranger L, Brizard F, Radford I, Jeanpierre M, Bernard OA, Berger R
Leukemia 1999; 13 (12) : 1975-1981.
PMID 10602418
 
Prognostic Implications of Morphology and Karyotype in Primary Myelodysplastic Syndromes
Jacobs RH, Cornbleet MA, Vardiman JW, Larson RA, Le Beau MM, Rowley JD
Blood. 1986; 67(6): 1765-1772.
PMID 3708160
 
Hypodiploidy is a major prognostic factor in multiple myeloma
Smadja NV, Bastard C, Brigaudeau C, Leroux D, Fruchart C
Blood. 2001; 98(7): 2229-2238
PMID 11568011
 
Cytogenetic evaluation of large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-21
Tomlinson GE, Douglass EC, Pollock BH, Finegold MJ, Schneider NR
Genes, Chromosomes Cancer. 2005; 44(2):177-184
PMID 3708160
 

Citation

This paper should be referenced as such :
Shen Y, Gillan T, Bruyère H
t(1;2)(q12;q37) in acute leukemias;
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0102q12q37ID1317.html
History of this paper:
Huret, JL. t(1;2)(q12;q37). Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):31-31.
http://documents.irevues.inist.fr/bitstream/handle/2042/37590/02-2000-t0102q12q37ID1317.pdf


Translocations implicated (Data extracted from papers in the Atlas)

 t(1;2)(q12;q37)

External links

Mitelman databaset(1;2)(q12;q37) [Case List]    t(1;2)(q12;q37) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9811/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(1;2)(q12;q37) in acute leukemias
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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