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t(1;6)(p35;p25) ?/IRF4

Written2005-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 1378
 
  t(1;6)(p35;p25) G- banding - top: Courtesy Melanie Zenger and Claudia Haferlach; bottom Courtesy Aurelia Meloni-Ehrig.

Clinics and Pathology

Disease Chronic lymphocytic leukemia (CLL)
Phenotype / cell stem origin Unmutated status of IgVH (an unfavourable prognostic feature) was found in all cases.
Epidemiology 8 patients to date, representing 0.5% of CLL cases in a country based survey; sex ratio: 6 male/2 female patients, aged 33-81 years (med: 62.5 years).
Clinics Two cases in Binet stage A, 4 in stage B, 2 in stage C. Normal LDH values in 7 of 8.
Prognosis Yet unknown (median follow up is only 28 months), but 3 patients developed a diffuse large B-cell lymphoma (DLBCL), and 3 patients (2 of which with DLBCL) died at 29, 76, and 95 months.

Cytogenetics

Additional anomalies Sole anomaly in three cases, with +12 in three cases, with 9q anomalies in three, del(11q) in two, 17p anomalies in two, 17q anomalies in two; del(11q), and 17p anomalies are poor prognostic factors in CLL.

Genes involved and Proteins

Note IRF4 (6p25.2) is possibly involved in the translocation. The gene in 1p35.3 is unknown.

To be noted

Case Report Translocation t(1;6)(p35;p25) in B-cell lymphoproliferative disorder with evolution to Diffuse Large B-cell Lymphoma
Case Report Chronic lymphocytic leukaemia/Small lymphocytic lymphoma (CLL/SLL) associated with translocation t(1;6)(p35;p25) as part of complex karyotype

Bibliography

Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in unmutated B-CLL.
Michaux L, Wlodarska I, Rack K, Stul M, Criel A, Maerevoet M, Marichal S, Demuynck H, Mineur P, Kargar Samani K, Van Hoof A, Ferrant A, Marynen P, Hagemeijer A
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (1) : 77-82.
PMID 15510210
 

Citation

This paper should be referenced as such :
Huret, JL
t(1;6)(p35;p25)
Atlas Genet Cytogenet Oncol Haematol. 2005;9(1):28-29.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0106p35p25ID1378.html


Other genes implicated (Data extracted from papers in the Atlas) [ 1 ]

Genes IRF4

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;6)(p35;p25) ?/IRF4

External links

arrayMap (UZH-SIB Zurich)
Mitelman databaset(1;6)(p35;p25) [Case List]    t(1;6)(p35;p25) [Association List] Mitelman database (CGAP - NCBI)
arrayMap[select an item]
 
 
Disease databaset(1;6)(p35;p25) ?/IRF4
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Thu Jan 12 11:17:59 CET 2017


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