| Clinics and Pathology |
| Disease | Chronic lymphocytic leukemia (CLL) |
| Phenotype / cell stem origin | unmutated status of IgVH (an unfavourable prognostic feature) was found in all cases. |
| Epidemiology | 8 patients to date, representing 0.5% of CLL cases in a country based survey; sex ratio: 6 male/2 female patients, aged 33-81 yrs (med: 62.5 yrs). |
| Clinics | Two cases in Binet stage A, 4 in stage B, 2 in stage C. Normal LDH values in 7 of 8. |
| Prognosis | yet unknown (median follow up is only 28 mths), but 3 patients developed a diffuse large B-cell lymphoma (DLBCL), and 3 patients (2 of which with DLBCL) died at 29, 76, and 95 mths. |
| Cytogenetics |
| Additional anomalies | sole anomaly in three cases, with +12 in three cases, with 9q anomalies in three, del(11q) in two, 17p anomalies in two, 17q anomalies in two; del(11q), and 17p anomalies are poor prognostic factors in CLL. |
| Genes involved and Proteins |
| Note | IRF4 (6p25.2) is possibly involved in the translocation. The gene in 1p35.3 is unknown. |
| External links |
| Other database | t(1;6)(p35;p25) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;6)(p35;p25) | CancerChromosomes (NCBI) |
| To be noted |
| Case Report | Translocation t(1;6)(p35;p25) in B-cell lymphoproliferative disorder with evolution to Diffuse Large B-cell Lymphoma |
| Bibliography |
| Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in unmutated B-CLL. |
| Michaux L, Wlodarska I, Rack K, Stul M, Criel A, Maerevoet M, Marichal S, Demuynck H, Mineur P, Kargar Samani K, Van Hoof A, Ferrant A, Marynen P, Hagemeijer A |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (1) : 77-82. |
| PMID 15510210 |
| Contributor(s) |
| Written | 01-2005 | Jean loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;6)(p35;p25). Atlas Genet Cytogenet Oncol Haematol. January 2005 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0106p35p25ID1378.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:11:51 2008 |
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