t(1;6)(p36;p21)
2008-12-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but also chronic lymphoproliferative diseases (CLD)
Phenotype stem cell origin
The MDS case was a refractory anaemia with ringed sideroblasts (RARS), the AML case was a treatment related leukaemia (t-AML) (Hirst et al., 1993; Olney et al., 2002). The two CLD cases were chronic lymphocytic leukaemia (CLL) cases, one of which being atypical (Datta et al., 1991; Martin-Subero et al., 2007). This translocation is likely to be heterogenous.
Epidemiology
Only four cases to date; the case with RARS was a 72-year-old male patient, the t-AML case was also a male patient; the CLL cases (1 male and 1 female patients) were aged 35 and 75.
Prognosis
No data.
Genes Involved and Proteins
Note
Genes involved are unknown.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 1913607 | 1991 | Chromosome analyses in chronic lymphocytic leukemia and related B-cell neoplasms. | Datta T et al |
| 8431916 | 1993 | Consistent interstitial chromosomal deletions in myeloid malignancies and their correlation with fragile sites. | Hirst WJ et al |
| 17495977 | 2007 | A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. | Martín-Subero JI et al |
| 11921275 | 2002 | Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop. | Olney HJ et al |
Citation
Jean-Loup Huret
t(1;6)(p36;p21)
Atlas Genet Cytogenet Oncol Haematol. 2008-12-01
Online version: http://atlasgeneticsoncology.org/haematological/1530/t(1;6)(p36;p21)
