Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Written2008-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

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ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1530

Clinics and Pathology

Disease Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but also chronic lymphoproliferative diseases (CLD)
Phenotype / cell stem origin The MDS case was a refractory anaemia with ringed sideroblasts (RARS), the AML case was a treatment related leukaemia (t-AML) (Hirst et al., 1993; Olney et al., 2002). The two CLD cases were chronic lymphocytic leukaemia (CLL) cases, one of which being atypical (Datta et al., 1991; Martin-Subero et al., 2007). This translocation is likely to be heterogenous.
Epidemiology Only four cases to date; the case with RARS was a 72-year-old male patient, the t-AML case was also a male patient; the CLL cases (1 male and 1 female patients) were aged 35 and 75.
Prognosis No data.


Cytogenetics Morphological Sole anomaly in one myeloid and one lymphoid case, accompanied with del(11q) and del(13q) in the RARS, and +12, and t(14;19)(q32;q13) with IgH/BCL3 rearrangement in one CLL case.

Genes involved and Proteins

Note Genes involved are unknown.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Chromosome analyses in chronic lymphocytic leukemia and related B-cell neoplasms.
Datta T, Bauchinger M, Emmerich B, Reichle A.
Cancer Genet Cytogenet. 1991 Aug;55(1):49-56.
PMID 1913607
Consistent interstitial chromosomal deletions in myeloid malignancies and their correlation with fragile sites.
Hirst WJ, Czepulkowski B, Mufti GJ.
Cancer Genet Cytogenet. 1993 Jan;65(1):51-7.
PMID 8431916
A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation.
Martin-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F, Calasanz MJ, De Wolf-Peeters C, Dyer MJ, Felman P, Gardiner A, Gascoyne RD, Gesk S, Harder L, Horsman DE, Kneba M, Kuppers R, Majid A, Parry-Jones N, Ritgen M, Salido M, Sole F, Thiel G, Wacker HH, Oscier D, Wlodarska I, Siebert R.
Leukemia. 2007 Jul;21(7):1532-44. Epub 2007 May 10.
PMID 17495977
Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop.
Olney HJ, Mitelman F, Johansson B, Mrozek K, Berger R, Rowley JD.
Genes Chromosomes Cancer. 2002 Apr;33(4):413-23.
PMID 11921275


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2009;13(11):881-881.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databaset(1;6)(p36;p21) [Case List]    t(1;6)(p36;p21) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9920/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Fri Mar 16 15:49:00 CET 2018

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