t(1;7)(p36;q34)

1999-11-01 Antonio Cuneo Affiliation

1.Hematology Section, Dept. Of Biomedical Sciences, University of Ferrara, 44100 Ferrara Italy

Clinics and Pathology

Disease

acute myeloid leukemia (AML), presenting as a de novo condition or after preceeding myelodysplastic syndrome or exposure to myelotoxic agents

Phenotype stem cell origin

M2/M4 by FAB criteria, frequently with trilineage myelodysplasia: positivity for myeloid markers (i.e. CD13, CD33) as well as for CD117, CD34 and TdT; lymphoid-associated markers tested negative in the reported cases

Epidemiology

the frequency of this anomaly in AML is < 1%

Prognosis

the cells may be susceptible to chemotherapy since all reported cases achieved complete remission, despite the presence of other unfavourable prognostic factors

Cytogenetics

Cytogenetics morphological

the translocation is easy to visualize in G-banded preparations because the dark 7q35 band moves on top of the derivative 1p

Additional anomalies

associated / additional anomalies may include +8 and the classical t(6;9)(p23;q34)

Genes Involved and Proteins

Note

the involved genes are unknown

Bibliography

Pubmed ID	Last Year	Title	Authors
8573309	1995	The role of chromosome translocations in T cell acute leukemia.	Hwang LY et al
10233385	1999	A novel translocation t(1;7)(p36;q34) in three patients with acute myeloid leukaemia.	Specchia G et al
8055471	1994	t(1;7)(p36;q32): a new recurring abnormality in primary myelodysplastic syndrome.	Stefănescu DT et al

Summary

partial karyotype (G-banding) showing the t(1;7)(p36;q34)

Citation

Antonio Cuneo

t(1;7)(p36;q34)

Atlas Genet Cytogenet Oncol Haematol. 1999-11-01

Online version: http://atlasgeneticsoncology.org/haematological/1157/t(1;7)(p36;q34)