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t(1;7)(p36;q34)

Written1999-11Antonio Cuneo
Hematology Section, Dept. Of Biomedical Sciences, University of Ferrara, 44100 Ferrara Italy

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
Atlas_Id 1157
 
  partial karyotype (G-banding) showing the t(1;7)(p36;q34)

Clinics and Pathology

Disease acute myeloid leukemia (AML), presenting as a de novo condition or after preceeding myelodysplastic syndrome or exposure to myelotoxic agents
Phenotype / cell stem origin M2/M4 by FAB criteria, frequently with trilineage myelodysplasia: positivity for myeloid markers (i.e. CD13, CD33) as well as for CD117, CD34 and TdT; lymphoid-associated markers tested negative in the reported cases
Epidemiology the frequency of this anomaly in AML is < 1%
Prognosis the cells may be susceptible to chemotherapy since all reported cases achieved complete remission, despite the presence of other unfavourable prognostic factors

Cytogenetics

Note this translocation may be related to a 1p;7q translocation described in myelodysplastic syndrome, whereas it must be distinguished from the T-ALL associated t(1;7)(p32;q34), involving the TCR gene and a more proximal breakpoint on 7q
Cytogenetics Morphological the translocation is easy to visualize in G-banded preparations because the dark 7q35 band moves on top of the derivative 1p
Additional anomalies associated / additional anomalies may include +8 and the classical t(6;9)(p23;q34)

Genes involved and Proteins

Note the involved genes are unknown

Bibliography

The role of chromosome translocations in T cell acute leukemia.
Hwang LY, Baer RJ
Current opinion in immunology. 1995 ; 7 (5) : 659-664.
PMID 8573309
 
A novel translocation t(1;7)(p36;q34) in three patients with acute myeloid leukaemia.
Specchia G, Cuneo A, Liso V, Contino R, Pastore D, Gentile E, Rocchi M, Castoldi GL
British journal of haematology. 1999 ; 105 (1) : 208-214.
PMID 10233385
 
t(1;7)(p36;q32): a new recurring abnormality in primary myelodysplastic syndrome.
Stefanescu DT, Colita D, Nicoara S, Calin G
Cancer genetics and cytogenetics. 1994 ; 75 (2) : 103-105.
PMID 8055471
 

Citation

This paper should be referenced as such :
Cuneo, A
t(1;7)(p36;q34)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(4):195-195.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0107ID1157.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(1;7)(p36;q34)

External links

Mitelman databaset(1;7)(p36;q34) [Case List]    t(1;7)(p36;q34) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9920/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(1;7)(p36;q34)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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