| Written | 2005-09 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9920/3 Therapy-related myeloid neoplasms |
| Atlas_Id | 1169 |
| Clinics and Pathology |
| Disease | Acute myeloid leukemia (AML), M2-AML type; this leukemia case is likely to be treatment related (see below) |
| Epidemiology | only 1 case to date, a 55yr old male patient who has had a non Hodgkin lymphoma (NHL) with t(14;18)(q32;q21) 3 yrs before onset of the AML. |
| Evolution | Complete remission of the AML was achieved, but the NHL relapsed and an advanced gastric carcinoma was found and the patient died shortly afterwards. |
| Genes involved and Proteins |
| Note | This translocation appears to be closely related to other translocations involving NUP98 and an homeodomain bearing protein, i.e. the t(2;11)(q31;p15),.with HOXD13 or with HOXD11 involvement, the t(7;11)(p15;p15),.with HOXA9 or with HOXA13 involvement, the t(9;11)(q34;p15), with PRRX2 involvement, and the t(11;12)(p15;q13) ID: n°identif> with HOXC11 or with |
| Gene Name | PRRX1 (paired related homeobox 1) |
| Location | 1q24.2 |
| Protein | Protein with a homeodomain |
| Result of the chromosomal anomaly |
| Description | In frame fusion of NUP98 to PRRX1 exon 2; no reciprocal fusion transcript |
| Description | The chimeric protein contains the N-term half of NUP98, including the docking site to the homeodomain of PRRX1. |
| Oncogenesis | The PRRX1 homeodomain may be upregulated |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Translocation (1;11)(q23;p15), a novel simple variant of translocation (7;11)(p15;p15), in a patient with AML (M2) accompanied by non-Hodgkin lymphoma and gastric cancer. |
| Hatano Y, Miura I, Kume M, Miura AB |
| Cancer genetics and cytogenetics. 2000 ; 117 (1) : 19-23. |
| PMID 10700860 |
| NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). |
| Nakamura T, Yamazaki Y, Hatano Y, Miura I |
| Blood. 1999 ; 94 (2) : 741-747. |
| PMID 10397741 |
| Citation |
| This paper should be referenced as such : |
| Huret, JL |
| t(1;11)(q23;p15) |
| Atlas Genet Cytogenet Oncol Haematol. 2006;10(2):114-114. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t0111q23p15ID1169.html |
| Other genes implicated (Data extracted from papers in the Atlas) [ 1 ] |
| Genes | NUP98 |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(1;11)(q23;p15) NUP98/PRRX1 | |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Sep 18 17:19:04 CEST 2017 |
For comments and suggestions or contributions, please contact us