Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(1;7)(p32;q34)
t(1;14)(p32;q11)
1p32 rearrangements
| Identity |
| Note | the two chromosome anomalies are variants of each other, and they share identical features |
 | |
| t(1;14)(p32;q11) ) G-banding - Courtesy Diane H. Norback, Eric B. Johnson, and Sara Morrison-Delap, UW Cytogenetic Services | |
| Clinics and Pathology |
| Disease | T- cell ALL |
| Epidemiology | rare findings; t(1;14) is found in approximately 3% of T-ALL; t(1;7) is rarer (status 3: < 5 cases); however, TAL1 rearrangements, all together (being mostly submicroscopic deletions without visible 1p32 involvement), occurs in 15-25% of T-ALL; male predominance (as is classical in T-cell ALL) |
| Clinics | organomegaly; high WBC (median 200X 109/l) |
| Cytogenetics |
| Additional anomalies | t(1;14) is found solely in about half cases, and accompanied by del(6q) in nearly half cases as well |
| Genes involved and Proteins |
| Gene Name | TAL1 |
| Location | 1p32 |
| Dna / Rna | complex alternate splicing |
| Protein | contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation |
| Gene Name | TRA/D |
| Location | 14q11 in the case of a t(1;14) |
| Gene Name | TRB |
| Location | 7q35 in the case of a t(1;7) |
| Result of the chromosomal anomaly |
 | |
| Description | in most cases (breakpoints between exons 2B and 3 of TAL1), 3' TAL1 joins variable and diversity segments of TCR on der(14); in the few cases where the breakpoint is within exon 6 of TAL1 or 3' from it, constant segments of TCR join TAL1 on der(1) |
| External links |
| Other database | t(1;7)(p32;q34) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;7)(p32;q34) | CancerChromosomes (NCBI) | |
| Other database | t(1;14)(p32;q11) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;14)(p32;q11) | CancerChromosomes (NCBI) |
| Bibliography |
| Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study. |
| Bash RO, Crist WM, Shuster JJ, Link MP, Amylon M, Pullen J, Carroll AJ, Buchanan GR, Smith RG, Baer R |
| Blood. 1993 ; 81 (8) : 2110-2117. |
| PMID 8471769 |
| Contributor(s) |
| Written | 01-1998 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;7)(p32;q34); t(1;14)(p32;q11); 1p32 rearrangements. Atlas Genet Cytogenet Oncol Haematol. January 1998 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0114.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Jul 3 11:53:36 CEST 2010 |
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