Written | 2004-02 | Jean-Loup Huret |
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
ICD-Morpho | 9811/3 B lymphoblastic leukaemia/lymphoma, NOS |
Atlas_Id | 1319 |
Note | the 2 translocations t(1;14)(q21;q32) and t(1;22) are variants of each other This t(1;14)(q21;q32) with BCL9 involvement is different from the t(1;14)(q21;q32) with FCGR2B involvement, from the t(1;14)(q21;q32) with MUC1 involvement and from the t(1;14)(q21;q32) with IRTA1 involvement. |
Clinics and Pathology |
Disease | Acute lymphoblastic leukemia (ALL) and non Hodgkin lymphoma (NHL) |
Epidemiology | a case of ALL in a 30 yr old male patient, a case of follicular NHL in a 57 yr old female patient, and a case of mantle cell lymphoma in a 87 yr old female patient |
Prognosis | prognosis was poor in 2 cases |
Cytogenetics |
Cytogenetics Morphological | There was a t(14;18)(q32;q21) and a complex karyotype in the follicular NHL caset, and a t(11;14)(q13;q32) and a complex karyotype in the case of mantle cell lymphoma case |
Genes involved and Proteins |
Gene Name | BCL9 (B-cell CLL/lymphoma 9) |
Location | 1q21.2 |
Protein | involved in Wnt signal transduction |
Gene Name | IGH (Immunoglobulin Heavy) |
Location | 14q32.33 |
Note | Immunoglobulin genes |
Gene Name | IGL (Immunoglobulin Lambda) |
Location | 22q11.22 |
Note | Immunoglobulin genes |
To be noted |
Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
Bibliography |
Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21. |
Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ |
Blood. 1998 ; 91 (6) : 1873-1881. |
PMID 9490669 |
Citation |
This paper should be referenced as such : |
Huret, JL |
t(1;14)(q21;q32) BCL9/IGH - t(1;22)(q21;q11) |
Atlas Genet Cytogenet Oncol Haematol. 2004;8(2):103-103. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0114q21q32ID1319.html |
Other genes implicated (Data extracted from papers in the Atlas) [ 1 ] |
Genes | BCL9 |
Translocations implicated (Data extracted from papers in the Atlas) |
t(1;14)(q21;q32) BCL9/IGH | |
t(1;22)(q21;q11) IGL/BCL9 | |
External links |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:25:18 CET 2020 |
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