t(1;14)(q21;q32) BCL9/IGH
t(1;22)(q21;q11) IGL/BCL9
2004-02-01 Jean-Loup Huret
Affiliation
1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Acute lymphoblastic leukemia (ALL) and non Hodgkin lymphoma (NHL)
Epidemiology
a case of ALL in a 30 yr old male patient, a case of follicular NHL in a 57 yr old female patient, and a case of mantle cell lymphoma in a 87 yr old female patient
Prognosis
prognosis was poor in 2 cases
Genes Involved and Proteins
Gene name
BCL9 (B-cell CLL/lymphoma 9)
Location
1q21.2
Protein description
involved in Wnt signal transduction
Gene name
IGL (Immunoglobulin Lambda)
Location
22q11.22
Note
Immunoglobulin genesImmunoglobulin genes
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9490669 | 1998 | Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21. | Willis TG et al |
Summary
Fusion gene
IGL/BCL9 IGL (22q11.22) BCL9 (1q21.2) M t(1;22)(q21;q11)
Note
the 2 translocations t(1;14)(q21;q32) and t(1;22) are variants of each other
This t(1;14)(q21;q32) with BCL9 involvement is different from the t(1;14)(q21;q32) with FCGR2B involvement, from the t(1;14)(q21;q32) with MUC1 involvement and from the t(1;14)(q21;q32) with IRTA1 involvement.
This t(1;14)(q21;q32) with BCL9 involvement is different from the t(1;14)(q21;q32) with FCGR2B involvement, from the t(1;14)(q21;q32) with MUC1 involvement and from the t(1;14)(q21;q32) with IRTA1 involvement.
Citation
Jean-Loup Huret
t(1;14)(q21;q32) BCL9/IGH
t(1;22)(q21;q11) IGL/BCL9
Atlas Genet Cytogenet Oncol Haematol. 2004-02-01
Online version: http://atlasgeneticsoncology.org/haematological/1319/t(1;14)(q21;q32)-bcl9-igh-br-t(1;22)(q21;q11)-igl-bcl9
