| Identity |
| Note | the 2 translocations t(1;14)(q21;q32) and t(1;22) are variants of each other This t(1;14)(q21;q32) with BCL9 involvement is different from the t(1;14)(q21;q32) with FCGR2B involvement, from the t(1;14)(q21;q32) with MUC1 involvement and from the t(1;14)(q21;q32) with IRTA1 involvement. |
| Clinics and Pathology |
| Disease | Acute lymphoblastic leukemia (ALL) and non Hodgkin lymphoma (NHL) |
| Epidemiology | a case of ALL in a 30 yr old male patient, a case of follicular NHL in a 57 yr old female patient, and a case of mantle cell lymphoma in a 87 yr old female patient |
| Prognosis | prognosis was poor in 2 cases |
| Cytogenetics |
| Cytogenetics Morphological | There was a t(14;18)(q32;q21) and a complex karyotype in the follicular NHL caset, and a t(11;14)(q13;q32) and a complex karyotype in the case of mantle cell lymphoma case |
| Genes involved and Proteins |
| Gene Name | BCL9 |
| Location | 1q21 |
| Protein | involved in Wnt signal transduction |
| Gene Name | Immunoglobulin genes : IGH, IGL |
| Location | located in 14q32 and 22q11 respectively |
| External links |
| Other database | t(1;14)(q21;q32) BCL9/IGH | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;14)(q21;q32) BCL9/IGH | CancerChromosomes (NCBI) | |
| Other database | t(1;22)(q21;q11) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;22)(q21;q11) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21. |
| Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ |
| Blood. 1998 ; 91 (6) : 1873-1881. |
| PMID 9490669 |
| Contributor(s) |
| Written | 02-2004 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;14)(q21;q32) BCL9/IGH,t(1;22)(q21;q11). Atlas Genet Cytogenet Oncol Haematol. February 2004 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0114q21q32ID1319.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:11:55 2008 |
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