Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(1;14)(q21;q32) BCL9::IGH

t(1;22)(q21;q11) IGL::BCL9

Written2004-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
Atlas_Id 1319
Note the 2 translocations t(1;14)(q21;q32) and t(1;22) are variants of each other
This t(1;14)(q21;q32) with BCL9 involvement is different from the t(1;14)(q21;q32) with FCGR2B involvement, from the t(1;14)(q21;q32) with MUC1 involvement and from the t(1;14)(q21;q32) with IRTA1 involvement.

Clinics and Pathology

Disease Acute lymphoblastic leukemia (ALL) and non Hodgkin lymphoma (NHL)
Epidemiology a case of ALL in a 30 yr old male patient, a case of follicular NHL in a 57 yr old female patient, and a case of mantle cell lymphoma in a 87 yr old female patient
Prognosis prognosis was poor in 2 cases


Cytogenetics Morphological There was a t(14;18)(q32;q21) and a complex karyotype in the follicular NHL caset, and a t(11;14)(q13;q32) and a complex karyotype in the case of mantle cell lymphoma case

Genes involved and Proteins

Gene NameBCL9 (B-cell CLL/lymphoma 9)
Location 1q21.2
Protein involved in Wnt signal transduction
Gene NameIGH (Immunoglobulin Heavy)
Location 14q32.33
Note Immunoglobulin genes
Gene NameIGL (Immunoglobulin Lambda)
Location 22q11.22
Note Immunoglobulin genes

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21.
Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ
Blood. 1998 ; 91 (6) : 1873-1881.
PMID 9490669


This paper should be referenced as such :
Huret, JL
t(1;14)(q21;q32) BCL9/IGH - t(1;22)(q21;q11)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(2):103-103.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 1 ]

Genes BCL9

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;14)(q21;q32) BCL9/IGH
 t(1;22)(q21;q11) IGL/BCL9

External links

IGL (22q11.22) BCL9 (1q21.2)

Mitelman databaset(1;14)(q21;q32)
Mitelman databaset(1;22)(q21;q11)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
Mitelman databaseIGL::BCL9 [MCList]  IGL (22q11.22) BCL9 (1q21.2)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 8 16:36:06 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us