t(1;14)(q21;q32) BCL9/IGH

t(1;22)(q21;q11) IGL/BCL9

Identity

ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho	9811/3 B lymphoblastic leukaemia/lymphoma, NOS
Atlas_Id	1319
Note	the 2 translocations t(1;14)(q21;q32) and t(1;22) are variants of each other This t(1;14)(q21;q32) with BCL9 involvement is different from the t(1;14)(q21;q32) with FCGR2B involvement, from the t(1;14)(q21;q32) with MUC1 involvement and from the t(1;14)(q21;q32) with IRTA1 involvement.

Clinics and Pathology

Disease	Acute lymphoblastic leukemia (ALL) and non Hodgkin lymphoma (NHL)
Epidemiology	a case of ALL in a 30 yr old male patient, a case of follicular NHL in a 57 yr old female patient, and a case of mantle cell lymphoma in a 87 yr old female patient
Prognosis	prognosis was poor in 2 cases

Cytogenetics

Cytogenetics Morphological

There was a t(14;18)(q32;q21) and a complex karyotype in the follicular NHL caset, and a t(11;14)(q13;q32) and a complex karyotype in the case of mantle cell lymphoma case

Genes involved and Proteins

Gene Name	BCL9 (B-cell CLL/lymphoma 9)
Location	1q21.2
Protein	involved in Wnt signal transduction

Gene Name	IGH (Immunoglobulin Heavy)
Location	14q32.33
Note	Immunoglobulin genes

Gene Name	IGL (Immunoglobulin Lambda)
Location	22q11.22
Note	Immunoglobulin genes

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section.

Bibliography

Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21.

Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ

Blood. 1998 ; 91 (6) : 1873-1881.

PMID 9490669

Citation

This paper should be referenced as such :

Huret, JL

t(1;14)(q21;q32) BCL9/IGH - t(1;22)(q21;q11)

Atlas Genet Cytogenet Oncol Haematol. 2004;8(2):103-103.

Free journal version : [ pdf ]   [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Anomalies/t0114q21q32ID1319.html

Translocations implicated (Data extracted from papers in the Atlas)

	t(1;14)(q21;q32) BCL9/IGH
	t(1;22)(q21;q11) IGL/BCL9

External links

IGL (22q11.22) BCL9 (1q21.2)

Mitelman database	t(1;14)(q21;q32) [Case List]    t(1;14)(q21;q32) [Transloc-MCList] BCL9/IGH [Fusion-MCList]
Mitelman database	t(1;22)(q21;q11) [Case List]    t(1;22)(q21;q11) [Transloc-MCList] IGL/BCL9 [Fusion-MCList]
arrayMap (UZH-SIB Zurich)	Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
Mitelman database	IGL/BCL9 [MCList]  IGL (22q11.22) BCL9 (1q21.2)

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Mar 11 20:41:13 CET 2020

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