| Written | 2000-02 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS |
| Atlas_Id | 1318 |
 | |
| t(1;16)(q12;q24) Fluorescence in situ hybridization with Vysis LSI 1p36/LSI 1q25 dual-color probe (Abbott molecular, US) showing extra copy of 1q25 on metaphase with der(16)t(1;16) (green signal on der(16) chromosome) – Courtesy Adriana Zamecnikova. | |
| Clinics and Pathology |
| Disease | Acute myeloid leukemia (AML) |
| Note | poorly known: only 2 cases to date |
| Phenotype / cell stem origin | a case of Fanconi anemia and a case of M1-AML |
| Epidemiology | The Fanconi anemia patient was a 9 yr old girl, and the AML case was a 22 yr old male patient |
| Prognosis | unknown |
| Cytogenetics |
| Cytogenetics Morphological | The t(1;16) presented as a der(16)t(1;16) in the 2 cases, resulting in trisomy 1q. The t(1;16) was the sole anomaly in each case. |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations. |
| Busson-Le Coniat M, Salomon-Nguyen F, Dastugue N, Maarek O, Lafage-Pochitaloff M, Mozziconacci MJ, Baranger L, Brizard F, Radford I, Jeanpierre M, Bernard OA, Berger R |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1999 ; 13 (12) : 1975-1981. |
| PMID 10602418 |
| Citation |
| This paper should be referenced as such : |
| Huret, JL |
| t(1;16)(q12;q24) |
| Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):30-30. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t0116q12q24ID1318.html |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(1;16)(q12;q24) | |
| External links |
| Mitelman database | t(1;16)(q12;q24) [Case List] t(1;16)(q12;q24) [Transloc-MCList] |
| arrayMap (UZH-SIB Zurich) | Topo ( C42) Morph ( 9861/3) - [auto + random 100 samples .. if exist ] [tabulated segments] |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Mar 25 16:48:38 CET 2019 |
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