Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(1;18)(q25;q23)

Written1999-09Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1162

Clinics and Pathology

Disease acute myeloid leukemia (AML) and acute lymphocycic leukemia (ALL)
Phenotype / cell stem origin M2 and M6AML, L2-ALL
Etiology 1 case was a therapy related AML, and the 2 other cases were found in Down syndrome (DS) patients
Epidemiology poorly known: only 3 cases to date; 3 female patients aged 1-13 yrs
Prognosis yet unknown : cases dead at 1 mth and alive at 2 mths+ (2 DS cases), alive at 12 mths+ (therapy related case)

Cytogenetics

Cytogenetics Morphological found as -18, +der(18)t(1;18)(q25;q23) in 2 of the 3 cases; unbalanced form, with 2 normal chromosomes 1, a der(18), and a normal chromosome 18: --> partial trisomy for 1q25-1qter and monosomy for 18q23-qter; reminiscent of the t(1;19)(q23;p13) unbalanced form

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Cytogenetic findings in leukemic cells of 56 patients with constitutional chromosome abnormalities. A cooperative study. Groupe Français de Cytogénétique Hématologique (GFCH).
Cancer genetics and cytogenetics. 1988 ; 35 (2) : 243-252.
PMID 2972356
 
A second known case of Down syndrome with t(1;18)(q25;q23) in leukemic cells.
Brozek I, Babińska M, Limon J, Zaborowska-Sol M, Ploszyńska A, Balcerska A
Cancer genetics and cytogenetics. 1999 ; 110 (2) : 136-137.
PMID 10214363
 
Two karyotypically independent leukemic clones with the t(8;21) and 11q23 translocation in acute myeloblastic leukemia at relapse.
Hayashi Y, Raimondi SC, Behm FG, Santana VM, Kalwinsky DK, Pui CH, Mirro J Jr, Williams DL
Blood. 1989 ; 73 (6) : 1650-1655.
PMID 2713498
 

Citation

This paper should be referenced as such :
Huret, JL
t(1;18)(q25;q23)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(3):155-155.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0118ID1162.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(1;18)(q25;q23)

External links

Mitelman databaset(1;18)(q25;q23) [Case List]    t(1;18)(q25;q23) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9811/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(1;18)(q25;q23)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 17:19:08 CEST 2017


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.