t(1;21)(p35;q22) RUNX1/YTHDF2
2007-09-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Acute myeloid leukaemia (AML)
Epidemiology
Only one case to date, a 68 year old male patient with M2 AML.
Prognosis
No data.
Genes Involved and Proteins
Gene name
YTHDF2 (YTH N6-methyladenosine RNA binding protein 2)
Location
1p35.3
Protein description
Possible role in immune response.
Gene name
RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location
21q22.12
Protein description
Transcription factor (activator) for various hematopoietic-specific genes, which expression is limited to hematopoetic stem cells, endothelial cells and mesenchymal cells in the embryo; core binding factor family member which forms heterodimers with CBFB; binds to the core site 5 PyGPyGGTPy 3 of promotors and enhancers.
Result of the Chromosomal Anomaly
Description
5 RUNX1 - 3 YTHDF2
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 16858696 | 2006 | Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia. | Nguyen TT et al |
Summary
Fusion gene
RUNX1/YTHDF2 RUNX1 (21q22.12) YTHDF2 (1p35.3) M t(1;21)(p35;q22)|RUNX1/YTHDF2 RUNX1 (21q22.12) YTHDF2 (1p35.3) TIC
Citation
Jean-Loup Huret
t(1;21)(p35;q22) RUNX1/YTHDF2
Atlas Genet Cytogenet Oncol Haematol. 2007-09-01
Online version: http://atlasgeneticsoncology.org/haematological/1447/t(1;21)(p35;q22)-runx1-ythdf2
