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t(1;21)(p35;q22) RUNX1::YTHDF2

Written2007-09Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1447

Clinics and Pathology

Disease Acute myeloid leukaemia (AML)
Epidemiology Only one case to date, a 68 year old male patient with M2 AML.
Prognosis No data.

Genes involved and Proteins

Gene NameYTHDF2 (YTH N6-methyladenosine RNA binding protein 2)
Location 1p35.3
Protein Possible role in immune response.
Gene NameRUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location 21q22.12
Protein Transcription factor (activator) for various hematopoietic-specific genes, which expression is limited to hematopoetic stem cells, endothelial cells and mesenchymal cells in the embryo; core binding factor family member which forms heterodimers with CBFB; binds to the core site 5' PyGPyGGTPy 3' of promotors and enhancers.

Result of the chromosomal anomaly

Hybrid gene
Description 5' RUNX1 - 3' YTHDF2

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia.
Nguyen TT, Ma LN, Slovak ML, Bangs CD, Cherry AM, Arber DA.
Genes Chromosomes Cancer. 2006 Oct;45(10):918-32.
PMID 16858696


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2008;12(5):400-400.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;21)(p35;q22) RUNX1/YTHDF2

External links

RUNX1 (21q22.12) YTHDF2 (1p35.3)

RUNX1 (21q22.12) YTHDF2 (1p35.3)

Mitelman databaset(1;21)(p35;q22)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
Mitelman databaseRUNX1::YTHDF2 [MCList]  RUNX1 (21q22.12) YTHDF2 (1p35.3)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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