| Clinics and Pathology |
| Disease | Acute myeloid leukaemia (AML) |
| Epidemiology | Only one case to date, a 68 year old male patient with M2 AML. |
| Prognosis | No data. |
| Genes involved and Proteins |
| Gene Name | YTHDF2 |
| Location | 1p35 |
| Protein | Possible role in immune response. |
| Gene Name | RUNX1 |
| Location | 21q22 |
| Protein | Transcription factor (activator) for various hematopoietic-specific genes, which expression is limited to hematopoetic stem cells, endothelial cells and mesenchymal cells in the embryo; core binding factor family member which forms heterodimers with CBFB; binds to the core site 5' PyGPyGGTPy 3' of promotors and enhancers. |
| Result of the chromosomal anomaly |
| Description | 5' RUNX1 - 3' YTHDF2 |
| External links |
| Other database | t(1;21)(p35;q22) | Mitelman database (CGAP - NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia. |
| Nguyen TT, Ma LN, Slovak ML, Bangs CD, Cherry AM, Arber DA. |
| Genes Chromosomes Cancer. 2006 Oct;45(10):918-32. |
| PMID 16858696 |
| Contributor(s) |
| Written | 09-2007 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;21)(p35;q22). Atlas Genet Cytogenet Oncol Haematol. Septem
ber 2007 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0121p35q22ID1447.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/38583/1/09-2007-t0121p35q22ID1447.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Mar 9 12:36:48 CET 2013 |
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