Written | 2009-06 | Yongquan Xue, Jean-Loup Huret |
Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, PR China (YX); Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH) |
Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
ICD-Morpho | 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS |
Atlas_Id | 2135 |
Clinics and Pathology |
Disease | Acute monocytic leukemia (AML-M5) |
Epidemiology | Only one case reported in the literature till now, a 53-year-old female patient (Dai et al., 2007). |
Prognosis | The patient was still in remission 26 months after diagnosis. |
Genes involved and Proteins |
Note | The gene partner in chromosome 1q12 is unknown. |
Gene Name | RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)) |
Location | 21q22.12 |
Dna / Rna | Transcription from telomere to centromere. |
Protein | Contains the RUNT binding domain at 5' portion and the transactivation domain at 3' portion. Forms heterodimers; widely expressed; nuclear localization; a transcription factor and critical regulator of hematopoietic-cell development. |
To be noted |
Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
Bibliography |
Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia. |
Dai H, Xue Y, Pan J,Wu Y, Wang Y, Shen J, Zhang J. |
Cancer Genet Cytogenet. 2007 Sep;177(2):120-4. |
PMID 17854666 |
Citation |
This paper should be referenced as such : |
Xue, Y ; Huret, JL |
t(1;21)(q12;q22) |
Atlas Genet Cytogenet Oncol Haematol. 2010;14(5):493-493. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0121q12q22ID2135.html |
Translocations implicated (Data extracted from papers in the Atlas) |
t(1;21)(q12;q22) RUNX1/? | |
External links |
Mitelman database | t(1;21)(q12;q22) |
arrayMap (UZH-SIB Zurich) | Topo ( C42) Morph ( 9861/3) - [auto + random 100 samples .. if exist ] [tabulated segments] |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:25:23 CET 2020 |
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