| Clinics and Pathology |
| Disease | Acute monocytic leukemia (AML-M5) |
| Epidemiology | Only one case reported in the literature till now, a 53-year-old female patient (Dai et al., 2007). |
| Prognosis | The patient was still in remission 26 months after diagnosis. |
| Genes involved and Proteins |
| Note | The gene partner in chromosome 1q12 is unknown. |
| Gene Name | RUNX1 |
| Location | 21q22 |
| Dna / Rna | Transcription from telomere to centromere. |
| Protein | Contains the RUNT binding domain at 5' portion and the transactivation domain at 3' portion. Forms heterodimers; widely expressed; nuclear localization; a transcription factor and critical regulator of hematopoietic-cell development. |
| External links |
| Other database | t(1;21)(q12;q22) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;21)(q12;q22) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia. |
| Dai H, Xue Y, Pan J,Wu Y, Wang Y, Shen J, Zhang J. |
| Cancer Genet Cytogenet. 2007 Sep;177(2):120-4. |
| PMID 17854666 |
| Contributor(s) |
| Written | 06-2009 | Yongquan Xue, Jean-Loup Huret |
| Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, PR China (YX); Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH) |
| Citation |
| This paper should be referenced as such : |
| Xue Y, Huret JL. . t(1;21)(q12;q22). Atlas Genet Cytogenet Oncol Haematol. June 2009 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0121q12q22ID2135.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Jul 3 11:53:39 CEST 2010 |
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