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t(1;21)(q12;q22) RUNX1/?

Written2009-06Yongquan Xue, Jean-Loup Huret
Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, PR China (YX); Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH)

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Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 2135

Clinics and Pathology

Disease Acute monocytic leukemia (AML-M5)
Epidemiology Only one case reported in the literature till now, a 53-year-old female patient (Dai et al., 2007).
Prognosis The patient was still in remission 26 months after diagnosis.

Genes involved and Proteins

Note The gene partner in chromosome 1q12 is unknown.
Gene NameRUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location 21q22.12
Dna / Rna Transcription from telomere to centromere.
Protein Contains the RUNT binding domain at 5' portion and the transactivation domain at 3' portion. Forms heterodimers; widely expressed; nuclear localization; a transcription factor and critical regulator of hematopoietic-cell development.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia.
Dai H, Xue Y, Pan J,Wu Y, Wang Y, Shen J, Zhang J.
Cancer Genet Cytogenet. 2007 Sep;177(2):120-4.
PMID 17854666
 

Citation

This paper should be referenced as such :
Xue, Y ; Huret, JL
t(1;21)(q12;q22)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(5):493-493.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0121q12q22ID2135.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(1;21)(q12;q22) RUNX1/?

External links

Mitelman databaset(1;21)(q12;q22) [Case List]    t(1;21)(q12;q22) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(1;21)(q12;q22) RUNX1/?
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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