| Written | 2009-06 | Yongquan Xue, Jean-Loup Huret |
| Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, PR China (YX); Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH) |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS |
| Atlas_Id | 2135 |
| Clinics and Pathology |
| Disease | Acute monocytic leukemia (AML-M5) |
| Epidemiology | Only one case reported in the literature till now, a 53-year-old female patient (Dai et al., 2007). |
| Prognosis | The patient was still in remission 26 months after diagnosis. |
| Genes involved and Proteins |
| Note | The gene partner in chromosome 1q12 is unknown. |
| Gene Name | RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)) |
| Location | 21q22.12 |
| Dna / Rna | Transcription from telomere to centromere. |
| Protein | Contains the RUNT binding domain at 5' portion and the transactivation domain at 3' portion. Forms heterodimers; widely expressed; nuclear localization; a transcription factor and critical regulator of hematopoietic-cell development. |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia. |
| Dai H, Xue Y, Pan J,Wu Y, Wang Y, Shen J, Zhang J. |
| Cancer Genet Cytogenet. 2007 Sep;177(2):120-4. |
| PMID 17854666 |
| Citation |
| This paper should be referenced as such : |
| Xue, Y ; Huret, JL |
| t(1;21)(q12;q22) |
| Atlas Genet Cytogenet Oncol Haematol. 2010;14(5):493-493. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t0121q12q22ID2135.html |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(1;21)(q12;q22) RUNX1/? | |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Aug 12 16:59:47 CEST 2019 |
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