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t(2;2)(p22;p22) LTBP1/BIRC6

del(2)(p22p22) LTBP1/BIRC6

Written2016-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France. jean-loup.huret@chu-poitiers.fr

Abstract Review on t(2;2)(p22;p22) and del(2)(p22p22) LTBP1/BIRC6 in acute myeloid leukemia, with data on the genes involved.

Keywords chromosome 2; t(2;2)(p22;p22); LTBP1; BIRC6; acute myeloid leukemia

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1714
Other namesNOTE

Clinics and Pathology

Note Only two cases to date of t(2;2)(p22;p22) or del(2)(p22p22) LTBP1/BIRC6 in acute myeloid leukemia have been described (Cancer Genome Atlas Research Network 2013; Yoshihara et al. 2015). This chromosomes and genes rearrangements have also been found in a case of breast carcinoma, and in a case of lung squamous cell carcinoma: t(2;2)(p22;p22) or del(2)(p22p22) LTBP1/BIRC6 in solid tumors.
Disease Acute myeloid leukemia
Epidemiology Data were described in only one case: a 75-year old male patient presented with AML-M2. Overall survival was 0.1 month (Cancer Genome Atlas Research Network 2013).
Cytogenetics The karyotype was normal (cryptic rearrangement).

Genes involved and Proteins

Note FLT3 mutation was positive; IDH1 R132, R140, R172 were negative; activating RAS was negative; NPMc was negative.
Gene NameBIRC6 (Baculoviral IAP repeat-containing 6)
Location 2p22.3
Protein BIRC6 contains two domains: a N-terminal BIR repeat (needed for interactions with caspases and IAP-binding motif (IBM) containing proteins) and a C-terminal UBC domain (which can form a thiolester linkage with ubiquitin transferred by E1).
Inhibitor of apoptosis: BIRC6 is a peripheral membrane protein of the trans-Golgi network that protects cells from apoptosis
BIRC6 and treatment resistance: Silencing of BIRC6 has been shown to sensitize cancer cells to various anticancer agents
BIRC6 is essential in embryonic development.
Regulator of cytokinesis: BIRC6 is a major regulator of abscission, the final stage of cytokinesis.
Regulator of mitosis: BIRC6 interacts with CCNA2 (cyclin A) and promotes its degradation in early mitosis
BIRC6 and autophagy: BIRC6 is required to inhibit autophagy
(Iris Luk and Wang, 2014).
BIRC6 is involved in myelodysplastic syndromes and acute myeloid leukemias, colorectal cancer, neuroblastoma, skin melanoma, non-small cell lung cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma and breast cancer.
Gene NameLTBP1 (latent transforming growth factor beta binding protein 1)
Location 2p22.3
Dna / Rna Eleven splice variants.
Protein 1721 amino acids; belongs to the LTBP/fibrillin family.
LTBP1 is composed of a signal peptide: (amino acids 1-23), 18 epidermal growth factor (EGF)-like repeats and four cysteines rich domains, the TB (TGFb binding protein-like) domains. The LTBP1 C-terminus interacts with the extracellular matrix via fibrillin microfibrils. EGF-like repeats provide stability to the protein structure
TGFB1 is secreted as a biologically latent complex composed of LTBP1, a latency associated peptide (LAP), (LAP is the TGFB1 pro-peptide which regulates latency, that is cleaved intracellularly prior to secretion), and the TGFB1 cytokine. LTBP1 plays roles in facilitating the folding and secretion of TGFB1 from the cell, and activation.
LTBP1 interacts with FBN1 (fibrillin 1). This interaction allows LTBP1 to sequester TGFB1 to fibrillin microfibrils; EFEMP2 (EGF containing fibulin-like extracellular matrix protein 2, or fibulin4) and ADAMTSL proteins form ternary complexes with LTBP1 and fibrillin.
LTBP1 is involved in epithelial-mesenchymal interaction and epithelial differentiation (Mazzieri et al., 2005; Robertson et al., 2014).

Result of the chromosomal anomaly

Hybrid gene
Description 5' LTBP1 - 3' BIRC6
  

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
Cancer Genome Atlas Research Network.
N Engl J Med. 2013 May 30;368(22):2059-74. doi: 10.1056/NEJMoa1301689. Epub 2013 May 1.
PMID 23634996
 
BIRC6 (Baculoviral IAP repeat-containing 6);
Jentsch, S ; Pohl, C.
Atlas Genet Cytogenet Oncol Haematol. http://atlasgeneticsoncology.org/Genes/BIRC6ID798ch2p22.html
 
Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling.
Mazzieri R, Jurukovski V, Obata H, Sung J, Platt A, Annes E, Karaman-Jurukovska N, Gleizes PE, Rifkin DB.
J Cell Sci. 2005 May 15;118(Pt 10):2177-87.
PMID 15870109
 
NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation.
Robertson IB, Handford PA, Redfield C.
PLoS One. 2014 Jan 29;9(1):e87125. doi: 10.1371/journal.pone.0087125.
PMID 24489852
 
The landscape and therapeutic relevance of cancer-associated transcript fusions.
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG.
Oncogene. 2015 Sep 10;34(37):4845-54. doi: 10.1038/onc.2014.406. Epub 2014 Dec 15.
PMID 25500544
 

Citation

This paper should be referenced as such :
Huret JL
t(2;2)(p22;p22) LTBP1/BIRC6; del(2)(p22p22) LTBP1/BIRC6;
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0202p22p22ID1714.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(2;2)(p22;p22) LTBP1/BIRC6

External links

Mitelman databaset(2;2)(p22;p22) [Case List]    t(2;2)(p22;p22) [Association List] Mitelman database (CGAP - NCBI)
arrayMapMorph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(2;2)(p22;p22) LTBP1/BIRC6
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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