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t(2;8)(p15;q24) BCL11A/MYC

Written2013-09Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2138

Clinics and Pathology

Disease Diffuse large B-cell lymphoma (DLBCL)
Epidemiology There was one female patient, and a male patient aged 81 years (Aamot et al., 2007; Bertrand et al., 2007).
Prognosis One patient died before treatment (Bertrand et al., 2007).

Cytogenetics

Cytogenetics Morphological A t(14;18)(q32;q21) was present in both cases. One case also presented with +5, +7, +12, and a marker chromosome.

Genes involved and Proteins

Note In the case described by Bertrand et al., 2007, breakpoints occurred close to MYC and BCL11A.
Gene Name BCL11A
Location 2p16
Protein BCL11A is a Krüppel zinc-finger transcription factor, which has been shown to be essential for pre-B-cell development, thymocyte maturation, and globin switching, expressed in haematopoietic and neural tissues. BCL11A controls FLT3 and IL7R expression in early hematopoietic progenitors (Wu et al., 2013).
Gene Name MYC
Location 8q24.2
Protein DNA binding protein. Binds DNA as a heterodimer with MAX. Involved in various cellular processes including cell growth, proliferation, cell adhesion, apoptosis, angiogenesis, and stem cell behaviour modulation.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Non-Hodgkin lymphoma with t(14;18): clonal evolution patterns and cytogenetic-pathologic-clinical correlations.
Aamot HV, Torlakovic EE, Eide MB, Holte H, Heim S.
J Cancer Res Clin Oncol. 2007 Jul;133(7):455-70. Epub 2007 Jan 18.
PMID 17235551
 
Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas.
Bertrand P, Bastard C, Maingonnat C, Jardin F, Maisonneuve C, Courel MN, Ruminy P, Picquenot JM, Tilly H.
Leukemia. 2007 Mar;21(3):515-23. Epub 2007 Jan 18.
PMID 17230227
 
Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.
Wu X, Satpathy AT, Kc W, Liu P, Murphy TL, Murphy KM.
PLoS One. 2013 May 31;8(5):e64800. doi: 10.1371/journal.pone.0064800. Print 2013.
PMID 23741395
 

Citation

This paper should be referenced as such :
Huret, JL
t(2;8)(p15;q24) BCL11A/MYC
Atlas Genet Cytogenet Oncol Haematol. 2014;18(4):278-278.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0208p15q24ID2138.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(2;8)(p15;q24) BCL11A/MYC

External links

arrayMap (UZH-SIB Zurich)
Mitelman databaset(2;8)(p15;q24) [Case List]    t(2;8)(p15;q24) [Association List] Mitelman database (CGAP - NCBI)
arrayMap[select an item]
 
 
Disease databaset(2;8)(p15;q24) BCL11A/MYC
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
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indexed on : Fri Jun 30 11:22:52 CEST 2017


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jlhuret@AtlasGeneticsOncology.org.