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t(2;8)(p15;q24) BCL11A/MYC

Written2013-09Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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Atlas_Id 2138

Clinics and Pathology

Disease Diffuse large B-cell lymphoma (DLBCL)
Epidemiology There was one female patient, and a male patient aged 81 years (Aamot et al., 2007; Bertrand et al., 2007).
Prognosis One patient died before treatment (Bertrand et al., 2007).


Cytogenetics Morphological A t(14;18)(q32;q21) was present in both cases. One case also presented with +5, +7, +12, and a marker chromosome.

Genes involved and Proteins

Note In the case described by Bertrand et al., 2007, breakpoints occurred close to MYC and BCL11A.
Gene NameBCL11A (B-cell lymphoma/leukemia 11A)
Location 2p16.1
Protein BCL11A is a Krüppel zinc-finger transcription factor, which has been shown to be essential for pre-B-cell development, thymocyte maturation, and globin switching, expressed in haematopoietic and neural tissues. BCL11A controls FLT3 and IL7R expression in early hematopoietic progenitors (Wu et al., 2013).
Gene NameMYC v-myc myelocytomatosis viral oncogene homolog (avian)
Location 8q24.21
Protein DNA binding protein. Binds DNA as a heterodimer with MAX. Involved in various cellular processes including cell growth, proliferation, cell adhesion, apoptosis, angiogenesis, and stem cell behaviour modulation.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Non-Hodgkin lymphoma with t(14;18): clonal evolution patterns and cytogenetic-pathologic-clinical correlations.
Aamot HV, Torlakovic EE, Eide MB, Holte H, Heim S.
J Cancer Res Clin Oncol. 2007 Jul;133(7):455-70. Epub 2007 Jan 18.
PMID 17235551
Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas.
Bertrand P, Bastard C, Maingonnat C, Jardin F, Maisonneuve C, Courel MN, Ruminy P, Picquenot JM, Tilly H.
Leukemia. 2007 Mar;21(3):515-23. Epub 2007 Jan 18.
PMID 17230227
Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.
Wu X, Satpathy AT, Kc W, Liu P, Murphy TL, Murphy KM.
PLoS One. 2013 May 31;8(5):e64800. doi: 10.1371/journal.pone.0064800. Print 2013.
PMID 23741395


This paper should be referenced as such :
Huret, JL
t(2;8)(p15;q24) BCL11A/MYC
Atlas Genet Cytogenet Oncol Haematol. 2014;18(4):278-278.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)

 t(2;8)(p15;q24) BCL11A/MYC

External links

Mitelman databaset(2;8)(p15;q24) [Case List]    t(2;8)(p15;q24) [Transloc-MCList] BCL11A/MYC [Fusion-MCList]
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
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