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der(3)t(3;3)(p25-26;q12-21)

Written2018-05Adriana Zamecnikova
Kuwait Cancer Control Center, Kuwait annaadria@yahoo.com

Abstract Partial or complete chromosome gains are frequently found in hematological malignancies, but the unbalanced der(3)t(3;3) is a relatively rare chromosome anomaly.

Keywords Chromosome 3 Myeloid malignancies; Lymphomas

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424
ICD-Morpho 9961/3 Primary myelofibrosis
ICD-Morpho 9983/3 Refractory anaemia with excess blasts
ICD-Morpho 9840/3 Acute erythroid leukaemia
ICD-Morpho 9705/3 Angioimmunoblastic T-cell lymphoma
ICD-Morpho 9690/3 Follicular lymphoma; Paediatric follicular lymphoma
ICD-Morpho 9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS; Primary DLBCL of the CNS; Primary cutaneous DLBCL, leg type; EBV positive DLBCL of the elderly; DLBCL associated with chronic inflammation; B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
ICD-Morpho 9673/3 Mantle cell lymphoma
Atlas_Id 1824
 
  Figure 1. Karyotype of the patient showing the unbalanced translocation of chromosome 3 and associated with 13q deletion.

Clinics and Pathology

Disease Myeloid malignancies and lymphomas
Etiology Myeloid malignancies in 3: 1 refractory anemia with excess blasts-1 (RAEB) (Yamamoto et al., 2004), 1 acute erythroleukemia (M6-AML) (Olopade et al, 1992) and the present patient diagnosed with acute myeloid leukemia (AML). In addition, there was a 66- years old female patient with 3q23 breakpoint diagnosed with idiopathic myelofibrosis (Reilly et al., 1997). 4 patients had various forms of lymphomas: 1 angioimmunoblastic T-cell lymphoma (Levine et al., 1985), 1 follicular lymphoma (Schlegelberger et al., 1990) 1 diffuse large B-cell lymphoma (Goyns et al., 1993) and 1 mantle cell lymphoma (Wlodarska et al., 19991).
Epidemiology Only 6 reported patients (3M/3F) aged 56, 66, 60 and 75 years (2 unknown) and the present 46-years old female patient (unpublished data).
Clinics The present patient was diagnosed with AML, NOS in 2006 and achieved complete hematological remission after chemotherapy but relapsed 4 years later. After bone marrow transplantation she maintained her remission status until November 2017 when she relapsed with 26% blasts in the blood.
Prognosis Found as part of highly complex karyotypes, therefore it may be associated with advanced-stage disease.

Cytogenetics

Cytogenetics Morphological Presents as 1 normal chromosome 3 and a der(3)t(3;3) chromosome and as 2 normal chromosomes 3 and +der(3) in 1 patient.
 
  Figure 2. Partial karyotypes showing the rearranged chromosome 3 (A). Fluorescence in situ hybridization with Keratech MECOM t(3;3); inv(3)(3q26) also known as EVI t(3;3); inv(3)(3q26) break-apart probe (Kreatech Biotechnology B.V., NL) showing 3 copies of the gene located on 3q26 as a result of the unbalanced translocation (B).

Result of the chromosomal anomaly

Fusion Protein
Oncogenesis der(3)t(3;3)(p25-26;q12-21) is a rare cytogenetic abnormality that has been observed in sporadic cases of myeloid malignancies and lymphomas. Mainly found as part of complex karyotypes with multiple numerical and structural anomalies, reflecting stepwise development of chromosomal abnormalities. The result of this unbalanced translocation is partial trisomy of the long arm of chromosome 3 causing deregulation of proto-oncogenes via gene dosage effect that may lead to their overexpression.
  

Bibliography

Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma
Goyns MH, Hammond DW, Harrison CJ, Menasce LP, Ross FM, Hancock BW
Leukemia 1993 Jun;7(6):848-52
PMID 8501979
 
There are differences in cytogenetic abnormalities among histologic subtypes of the non-Hodgkin's lymphomas
Levine EG, Arthur DC, Frizzera G, Peterson BA, Hurd DD, Bloomfield CD
Blood 1985 Dec;66(6):1414-22
PMID 4063528
 
Clinical, morphologic, and cytogenetic characteristics of 26 patients with acute erythroblastic leukemia
Olopade OI, Thangavelu M, Larson RA, Mick R, Kowal-Vern A, Schumacher HR, Le Beau MM, Vardiman JW, Rowley JD
Blood 1992 Dec 1;80(11):2873-82
PMID 1450412
 
Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: a study of 106 cases
Reilly JT, Snowden JA, Spearing RL, Fitzgerald PM, Jones N, Watmore A, Potter A
Br J Haematol 1997 Jul;98(1):96-102
PMID 9233570
 
Stepwise development of chromosomal abnormalities in angioimmunoblastic lymphadenopathy
Schlegelberger B, Feller A, Gödde E, Grote W, Lennert K
Cancer Genet Cytogenet 1990 Nov 1;50(1):15-29
PMID 2253183
 
Secondary chromosome changes in mantle cell lymphoma
Wlodarska I, Pittaluga S, Hagemeijer A, De Wolf-Peeters C, Van Den Berghe H
Haematologica 1999 Jul;84(7):594-9
PMID 10406899
 
Unbalanced translocation der(11)t(11;12)(q23;q13): a new recurrent cytogenetic aberration in myelodysplastic syndrome with a complex karyotype
Yamamoto K, Hato A, Minagawa K, Yakushijin K, Urahama N, Gomyo H, Sada A, Okamura A, Ito M, Matsui T
Cancer Genet Cytogenet 2004 Nov;155(1):67-73
PMID 15527905
 

Citation

This paper should be referenced as such :
Zamecnikova A
der(3)t(3;3)(p25-26;q12-21);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0303p25q12ID1824.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;3)(p25-26;q12-21)

External links

Mitelman databaset(3;3)(p25-26;q12-21) [Case List]    t(3;3)(p25-26;q12-21) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Morph ( 9961/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9983/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9840/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9705/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9690/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9680/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9673/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
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