ICD-Topo |
C420,C421,C424 |
ICD-Morpho |
9961/3 Primary myelofibrosis
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ICD-Morpho |
9980/3 Refractory anemia
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ICD-Morpho |
9840/3 Acute erythroid leukaemia
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ICD-Morpho |
9690/3 Follicular lymphoma; Paediatric follicular lymphoma
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ICD-Morpho |
9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS; Primary DLBCL of the CNS; Primary cutaneous DLBCL, leg type; EBV positive DLBCL of the elderly; DLBCL associated with chronic inflammation; B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
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ICD-Morpho |
9673/3 Mantle cell lymphoma
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ICD-Morpho |
9705/3 Angioimmunoblastic T-cell lymphoma
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Atlas_Id |
1824 |
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Figure 1. Karyotype of the patient showing the unbalanced translocation of chromosome 3 and associated with 13q deletion. Partial karyotypes showing the rearranged chromosome 3 (A). Fluorescence in situ hybridization with Keratech MECOM t(3;3); inv(3)(3q26) also known as EVI t(3;3); inv(3)(3q26) break-apart probe (Kreatech Biotechnology B.V., NL) showing 3 copies of the gene located on 3q26 as a result of the unbalanced translocation (B). |
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Disease |
Myeloid malignancies and lymphomas. |
Phenotype / cell stem origin |
Myeloid malignancies in 3 cases: 1 refractory anemia with excess blasts-1 (RAEB) (Yamamoto et al., 2004), 1 acute erythroleukemia (Olopade et al, 1992) and the present patient diagnosed with acute myeloid leukemia (AML). In addition, there was a 66- years old female patient with 3q23 breakpoint diagnosed with idiopathic myelofibrosis (Reilly et al., 1997). 4 patients had various forms of lymphomas: 1 angioimmunoblastic T-cell lymphoma (Levine et al., 1985), 1 follicular lymphoma (Schlegelberger et al., 1990) 1 diffuse large B-cell lymphoma (Goyns et al., 1993) and 1 mantle cell lymphoma (Wlodarska et al., 19991). |
Epidemiology | Only 6 reported patients (3M/3F) aged 56, 66, 60 and 75 years (2 unknown) and the present 46-years old female patient (unpublished data). |
Clinics | The present patient was diagnosed with AML, NOS in 2006 and achieved complete hematological remission after chemotherapy but relapsed 4 years later. After bone marrow transplantation she maintained her remission status until November 2017 when she relapsed with 26% blasts in the blood. |
Prognosis | Found as part of highly complex karyotypes, therefore it may be associated with advanced-stage disease. |
Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma. |
Goyns MH, Hammond DW, Harrison CJ, Menasce LP, Ross FM, Hancock BW. |
Leukemia 1993 Jun;7(6):848-52. |
PMID 8501979 |
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There are differences in cytogenetic abnormalities among histologic subtypes of the non-Hodgkin's lymphomas. |
Levine EG, Arthur DC, Frizzera G, Peterson BA, Hurd DD, Bloomfield CD. |
Blood 1985 Dec;66(6):1414-22. |
PMID 4063528 |
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Clinical, morphologic, and cytogenetic characteristics of 26 patients with acute erythroblastic leukemia. |
Olopade OI, Thangavelu M, Larson RA, Mick R, Kowal-Vern A, Schumacher HR, Le Beau MM, Vardiman JW, Rowley JD. |
Blood 1992 Dec 1;80(11):2873-82. |
PMID 1450412 |
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Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: a study of 106 cases. |
Reilly JT, Snowden JA, Spearing RL, Fitzgerald PM, Jones N, Watmore A, Potter A. |
Br J Haematol 1997 Jul;98(1):96-102. |
PMID 9233570 |
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Stepwise development of chromosomal abnormalities in angioimmunoblastic lymphadenopathy. |
Schlegelberger B, Feller A, Gödde E, Grote W, Lennert K. |
Cancer Genet Cytogenet 1990 Nov 1;50(1):15-29. |
PMID 2253183 |
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Secondary chromosome changes in mantle cell lymphoma. |
Wlodarska I, Pittaluga S, Hagemeijer A, De Wolf-Peeters C, Van Den Berghe H. |
Haematologica 1999 Jul;84(7):594-9. |
PMID 10406899 |
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Unbalanced translocation der(11)t(11;12)(q23;q13): a new recurrent cytogenetic aberration in myelodysplastic syndrome with a complex karyotype. |
Yamamoto K, Hato A, Minagawa K, Yakushijin K, Urahama N, Gomyo H, Sada A, Okamura A, Ito M, Matsui T. |
Cancer Genet Cytogenet 2004 Nov;155(1):67-73. |
PMID 15527905 |
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