| ICD-Topo |
C420,C421,C424 |
| ICD-Morpho |
9961/3 Primary myelofibrosis
|
| ICD-Morpho |
9983/3 Refractory anaemia with excess blasts
|
| ICD-Morpho |
9840/3 Acute erythroid leukaemia
|
| ICD-Morpho |
9705/3 Angioimmunoblastic T-cell lymphoma
|
| ICD-Morpho |
9690/3 Follicular lymphoma; Paediatric follicular lymphoma
|
| ICD-Morpho |
9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS; Primary DLBCL of the CNS; Primary cutaneous DLBCL, leg type; EBV positive DLBCL of the elderly; DLBCL associated with chronic inflammation; B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
|
| ICD-Morpho |
9673/3 Mantle cell lymphoma
|
| Atlas_Id |
1824 |
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Figure 1. Karyotype of the patient showing the unbalanced translocation of chromosome 3 and associated with 13q deletion. |
| |
| Disease |
Myeloid malignancies and lymphomas |
| Etiology | Myeloid malignancies in 3: 1 refractory anemia with excess blasts-1 (RAEB) (Yamamoto et al., 2004), 1 acute erythroleukemia (M6-AML) (Olopade et al, 1992) and the present patient diagnosed with acute myeloid leukemia (AML). In addition, there was a 66- years old female patient with 3q23 breakpoint diagnosed with idiopathic myelofibrosis (Reilly et al., 1997). 4 patients had various forms of lymphomas: 1 angioimmunoblastic T-cell lymphoma (Levine et al., 1985), 1 follicular lymphoma (Schlegelberger et al., 1990) 1 diffuse large B-cell lymphoma (Goyns et al., 1993) and 1 mantle cell lymphoma (Wlodarska et al., 19991). |
| Epidemiology | Only 6 reported patients (3M/3F) aged 56, 66, 60 and 75 years (2 unknown) and the present 46-years old female patient (unpublished data). |
| Clinics | The present patient was diagnosed with AML, NOS in 2006 and achieved complete hematological remission after chemotherapy but relapsed 4 years later. After bone marrow transplantation she maintained her remission status until November 2017 when she relapsed with 26% blasts in the blood. |
| Prognosis | Found as part of highly complex karyotypes, therefore it may be associated with advanced-stage disease. |
| Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma |
| Goyns MH, Hammond DW, Harrison CJ, Menasce LP, Ross FM, Hancock BW |
| Leukemia 1993 Jun;7(6):848-52 |
| PMID 8501979 |
| |
| There are differences in cytogenetic abnormalities among histologic subtypes of the non-Hodgkin's lymphomas |
| Levine EG, Arthur DC, Frizzera G, Peterson BA, Hurd DD, Bloomfield CD |
| Blood 1985 Dec;66(6):1414-22 |
| PMID 4063528 |
| |
| Clinical, morphologic, and cytogenetic characteristics of 26 patients with acute erythroblastic leukemia |
| Olopade OI, Thangavelu M, Larson RA, Mick R, Kowal-Vern A, Schumacher HR, Le Beau MM, Vardiman JW, Rowley JD |
| Blood 1992 Dec 1;80(11):2873-82 |
| PMID 1450412 |
| |
| Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: a study of 106 cases |
| Reilly JT, Snowden JA, Spearing RL, Fitzgerald PM, Jones N, Watmore A, Potter A |
| Br J Haematol 1997 Jul;98(1):96-102 |
| PMID 9233570 |
| |
| Stepwise development of chromosomal abnormalities in angioimmunoblastic lymphadenopathy |
| Schlegelberger B, Feller A, Gödde E, Grote W, Lennert K |
| Cancer Genet Cytogenet 1990 Nov 1;50(1):15-29 |
| PMID 2253183 |
| |
| Secondary chromosome changes in mantle cell lymphoma |
| Wlodarska I, Pittaluga S, Hagemeijer A, De Wolf-Peeters C, Van Den Berghe H |
| Haematologica 1999 Jul;84(7):594-9 |
| PMID 10406899 |
| |
| Unbalanced translocation der(11)t(11;12)(q23;q13): a new recurrent cytogenetic aberration in myelodysplastic syndrome with a complex karyotype |
| Yamamoto K, Hato A, Minagawa K, Yakushijin K, Urahama N, Gomyo H, Sada A, Okamura A, Ito M, Matsui T |
| Cancer Genet Cytogenet 2004 Nov;155(1):67-73 |
| PMID 15527905 |
| |
