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Written2013-09Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1110
  t(3;5)(q21;q31). G- banding (left) - top three: Courtesy Christine Perot; middle/bottom: Courtesy Francine Mugneret; bottom (RBA banding): Lucienne Michaux and Peter Vandenberghe; and R- banding (right) - top three: Courtesy Christine Perot; bottom three: Courtesy Francine Mugneret.

Clinics and Pathology

Disease Acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative disorder (MPD)
Note 26 cases of t(3;5)(q21;q31) in myeloid malignancy are available (Oshimura et al., 1976; Dewald, 1984; Bitter et al., 1985; Testa et al., 1985; Werner-Favre et al., 1985; Pi and Kalousek, 1986; Smadja et al., 1986; McCarthy et al., 1987; Sharp et al., 1987; Akiyoshi et al., 1991; Katz et al., 1992; Solé et al., 1992; Secker-Walker et al., 1995; Wong and Kwong, 1995; Groupe Français de Cytogénétique Hématologique, 1996; Dong et al., 1998; Mazzella et al., 1998; Misawa et al., 1998; Green et al., 1999; Berger et al., 2006; Lugthart et al., 2010). We have excluded from this review a case of acute lymphoblastic leukemia (Chen et al., 1992).
Phenotype / cell stem origin There was 5 M6-AMLs, 2 M4-AMLs, 10 M2-AMLs, and 6 AMLs not otherwise specified (AML-NOS), 1 myeloid metaplasia with myelofibrosis (MMM) in acute phase, another myeloproliferative syndrome not otherwise specified, and a refractory anemia with excess of blasts in transformation (RAEB-t). There was no reference with a previous toxic exposure.
Epidemiology Median age was 36-38 years (range 3-85, with two pediatric cases aged 3); sex ratio was 11M/14F.
Prognosis Data on survival is very scarce (patients alive at 3 months, 21 months, 29 months, and 30 months; and patients dead at 7 and 9 months).


Cytogenetics Morphological The t(3;5)(q21;q31) was the sole anomaly in 20 of 25 cases. Complex karyoptypes were present in 3 cases. A del(5q)/-5 was found in one case, a del(7q)/-7 was found in two cases, and a +8 in two cases.

Genes involved and Proteins

Note The genes involved in this translocation remain unknown.


Genotypic and cytogenetic study of acute myelocytic leukemia and chronic myelocytic leukemia in blast crisis: specific delta rearrangement pattern does not involve J delta gene locus.
Akiyoshi TT, Kimura N, Uike N, Kozuru M, Tamura K, Takihara Y, Hisano S, Nishimura J, Kikuchi M.
Leuk Res. 1991;15(8):683-91.
PMID 1654480
Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements.
Berger R, Busson M, Baranger L, Helias C, Lessard M, Dastugue N, Speleman F.
Leukemia. 2006 Feb;20(2):319-21.
PMID 16341035
Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia.
Bitter MA, Neilly ME, Le Beau MM, Pearson MG, Rowley JD.
Blood. 1985 Dec;66(6):1362-70.
PMID 4063525
Non-random involvement of chromosome 5 in ALL.
Chen Z, Morgan R, Sandberg AA.
Cancer Genet Cytogenet. 1992 Jul 1;61(1):106-7.
PMID 1638475
Fourth International Workshop on Chromosomes in Leukemia 1982: Abnormalities of chromosome 3 among 24 patients with de novo AML.
Dewald G.
Cancer Genet Cytogenet. 1984 March 1; 11(3):306.
Translocation(3;5)(q21-24;q31-34) in two cases of acute myeloid leukemia and in one case of thrombocytosis.
Dong SY, Morgan R, Van Ness L, Georgantas D, Meloni AM, Chen Z, Sandberg AA.
Cancer Genet Cytogenet. 1998 Apr 15;102(2):158.
PMID 9565463
Lack of IRF-1 expression in acute promyelocytic leukemia and in a subset of acute myeloid leukemias with del(5)(q31).
Green WB, Slovak ML, Chen IM, Pallavicini M, Hecht JL, Willman CL.
Leukemia. 1999 Dec;13(12):1960-71.
PMID 10602416
Possible evidence for genomic imprinting in childhood acute myeloblastic leukaemia associated with monosomy for chromosome 7.
Katz F, Webb D, Gibbons B, Reeves B, McMahon C, Chessells J, Mitchell C.
Br J Haematol. 1992 Mar;80(3):332-6.
PMID 1581212
Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia.
Lugthart S, Groschel S, Beverloo HB, Kayser S, Valk PJ, van Zelderen-Bhola SL, Jan Ossenkoppele G, Vellenga E, van den Berg-de Ruiter E, Schanz U, Verhoef G, Vandenberghe P, Ferrant A, Kohne CH, Pfreundschuh M, Horst HA, Koller E, von Lilienfeld-Toal M, Bentz M, Ganser A, Schlegelberger B, Jotterand M, Krauter J, Pabst T, Theobald M, Schlenk RF, Delwel R, Dohner K, Lowenberg B, Dohner H.
J Clin Oncol. 2010 Aug 20;28(24):3890-8. doi: 10.1200/JCO.2010.29.2771. Epub 2010 Jul 26.
PMID 20660833
Acute erythroleukemia: evaluation of 48 cases with reference to classification, cell proliferation, cytogenetics, and prognosis.
Mazzella FM, Kowal-Vern A, Shrit MA, Wibowo AL, Rector JT, Cotelingam JD, Collier J, Mikhael A, Cualing H, Schumacher HR.
Am J Clin Pathol. 1998 Nov;110(5):590-8.
PMID 9802343
Sweet's syndrome, acute leukemia, and t(3;5).
McCarthy CM, Cobcroft RG, Harris MG, Scott DC.
Cancer Genet Cytogenet. 1987 Sep;28(1):87-91.
PMID 3475167
Significance of chromosomal alterations and mutations of the N-RAS and TP53 genes in relation to leukemogenesis of acute myeloid leukemia.
Misawa S, Horiike S, Kaneko H, Sasai Y, Ueda Y, Nakao M, Yokota S, Taniwaki M, Fujii H, Nakagawa H, Tsuda S, Kashima K.
Leuk Res. 1998 Jul;22(7):631-7.
PMID 9680114
Chromosomes and causation of human cancer and leukemia. XVII. Banding studies in acute myeloblastic leukemia (AML).
Oshimura M, Hayata I, Kakati S, Sandberg AA.
Cancer. 1976 Aug;38(2):748-61.
PMID 1067891
Translocation t(3;5) in acute myelocytic leukemia type M2.
Pi D, Kalousek DK.
Cancer Genet Cytogenet. 1986 Feb 1;20(1-2):171.
PMID 3455856
Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study.
Secker-Walker LM, Mehta A, Bain B.
Br J Haematol. 1995 Oct;91(2):490-501.
PMID 8547101
t(3;5)(q21;q31) in a myelodysplastic syndrome.
Sharp RA, Robertson J, Heppleston AD.
Leuk Res. 1987;11(7):629-33.
PMID 3475514
Translocation t(3;5) and acute nonlymphocytic leukemia.
Smadja N, Krulik M, de Gramont A, Sirinelli A, Dray C, Brissaud P, Debray J.
Cancer Genet Cytogenet. 1986 Feb 1;20(1-2):173-4.
PMID 3943059
Cytogenetic studies in acute nonlymphocytic leukemia.
Sole F, Caballin MR, Coll MD, Woessner S, Besses C, Sans-Sabrafen J, Egozcue J.
Cancer Genet Cytogenet. 1992 Jun;60(2):117-24.
PMID 1606554
Chromosomal alterations in acute leukemia patients studied with improved culture methods.
Testa JR, Misawa S, Oguma N, Van Sloten K, Wiernik PH.
Cancer Res. 1985 Jan;45(1):430-4.
PMID 3855285
Translocation t(3;5) in AML.
Werner-Favre C, Engel E, Beris P.
Cancer Genet Cytogenet. 1985 Apr 1;16(3):279.
PMID 3978596
Complex variant t(3;5) (q21;q31), t(3;5;19)(q21;q31;p13) in acute myeloid leukemia.
Wong KF, Kwong YL.
Am J Hematol. 1995 Sep;50(1):70-1.
PMID 7668237
Cytogenetic analysis in patients with primary myelodysplastic syndromes in leukaemic transformation. A report on 94 cases. Groupe Francais de Cytogenetique Hematologique (GFCH).
[No authors listed]
Hematol Cell Ther. 1996 Apr;38(2):177-81.
PMID 8931999


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2014;18(3):200-202.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databaset(3;5)(q21;q31)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9975/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
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