t(3;5)(q21;q31)
2013-09-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative disorder (MPD)
Note
26 cases of t(3;5)(q21;q31) in myeloid malignancy are available (Oshimura et al., 1976; Dewald, 1984; Bitter et al., 1985; Testa et al., 1985; Werner-Favre et al., 1985; Pi and Kalousek, 1986; Smadja et al., 1986; McCarthy et al., 1987; Sharp et al., 1987; Akiyoshi et al., 1991; Katz et al., 1992; Solé et al., 1992; Secker-Walker et al., 1995; Wong and Kwong, 1995; Groupe Français de Cytogénétique Hématologique, 1996; Dong et al., 1998; Mazzella et al., 1998; Misawa et al., 1998; Green et al., 1999; Berger et al., 2006; Lugthart et al., 2010). We have excluded from this review a case of acute lymphoblastic leukemia (Chen et al., 1992).
Phenotype stem cell origin
There was 5 M6-AMLs, 2 M4-AMLs, 10 M2-AMLs, and 6 AMLs not otherwise specified (AML-NOS), 1 myeloid metaplasia with myelofibrosis (MMM) in acute phase, another myeloproliferative syndrome not otherwise specified, and a refractory anemia with excess of blasts in transformation (RAEB-t). There was no reference with a previous toxic exposure.
Epidemiology
Median age was 36-38 years (range 3-85, with two pediatric cases aged 3); sex ratio was 11M/14F.
Prognosis
Data on survival is very scarce (patients alive at 3 months, 21 months, 29 months, and 30 months; and patients dead at 7 and 9 months).
Genes Involved and Proteins
Note
The genes involved in this translocation remain unknown.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 1654480 | 1991 | Genotypic and cytogenetic study of acute myelocytic leukemia and chronic myelocytic leukemia in blast crisis: specific delta rearrangement pattern does not involve J delta gene locus. | Akiyoshi TT et al |
| 16341035 | 2006 | Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements. | Berger R et al |
| 4063525 | 1985 | Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia. | Bitter MA et al |
| 1638475 | 1992 | Non-random involvement of chromosome 5 in ALL. | Chen Z et al |
| 9565463 | 1998 | Translocation(3;5)(q21-24;q31-34) in two cases of acute myeloid leukemia and in one case of thrombocytosis. | Dong SY et al |
| 10602416 | 1999 | Lack of IRF-1 expression in acute promyelocytic leukemia and in a subset of acute myeloid leukemias with del(5)(q31). | Green WB et al |
| 1581212 | 1992 | Possible evidence for genomic imprinting in childhood acute myeloblastic leukaemia associated with monosomy for chromosome 7. | Katz F et al |
| 20660833 | 2010 | Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia. | Lugthart S et al |
| 9802343 | 1998 | Acute erythroleukemia: evaluation of 48 cases with reference to classification, cell proliferation, cytogenetics, and prognosis. | Mazzella FM et al |
| 3475167 | 1987 | Sweet's syndrome, acute leukemia, and t(3;5). | McCarthy CM et al |
| 9680114 | 1998 | Significance of chromosomal alterations and mutations of the N-RAS and TP53 genes in relation to leukemogenesis of acute myeloid leukemia. | Misawa S et al |
| 1067891 | 1976 | Chromosomes and causation of human cancer and leukemia. XVII. Banding studies in acute myeloblastic leukemia (AML). | Oshimura M et al |
| 3455856 | 1986 | Translocation t(3;5) in acute myelocytic leukemia type M2. | Pi D et al |
| 8547101 | 1995 | Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study. | Secker-Walker LM et al |
| 3475514 | 1987 | t(3;5)(q21;q31) in a myelodysplastic syndrome. | Sharp RA et al |
| 3943059 | 1986 | Translocation t(3;5) and acute nonlymphocytic leukemia. | Smadja N et al |
| 1606554 | 1992 | Cytogenetic studies in acute nonlymphocytic leukemia. | Solé F et al |
| 3855285 | 1985 | Chromosomal alterations in acute leukemia patients studied with improved culture methods. | Testa JR et al |
| 3978596 | 1985 | Translocation t(3;5) in ANLL. | Werner-Favre C et al |
| 7668237 | 1995 | Complex variant t(3;5) (q21;q31), t(3;5;19)(q21;q31;p13) in acute myeloid leukemia. | Wong KF et al |
| 8931999 | 1996 | Cytogenetic analysis in patients with primary myelodysplastic syndromes in leukaemic transformation. A report on 94 cases. Groupe Français de Cytogénétique Hématologique (GFCH). |
Summary
t(3;5)(q21;q31). G- banding (left) - top three: Courtesy Christine Perot; middle/bottom: Courtesy Francine Mugneret; bottom (RBA banding): Lucienne Michaux and Peter Vandenberghe; and R- banding (right) - top three: Courtesy Christine Perot; bottom three: Courtesy Francine Mugneret.
Citation
Jean-Loup Huret
t(3;5)(q21;q31)
Atlas Genet Cytogenet Oncol Haematol. 2013-09-01
Online version: http://atlasgeneticsoncology.org/haematological/1110/t(3;5)(q21;q31)
