t(3;6)(q27;q15) ?/BCL6
2012-11-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Non Hodgkin lymphoma
Clinics
The t(3;6) was found in two cases of follicular lymphoma (Sanger et al., 1987; Sanchez-Izquierdo et al., 2001).
Prognosis
The patient reported by Sanger et al., 1987 was a 83-year-old female patient with a follicular mixed small clived and large cell lymphoma, which evolved to a diffuse mixed small lymphocytic and large cell lymphoma. She experienced persistent disease under treatment, refused further chemotherapy, and died two years after diagnosis.
Genes Involved and Proteins
Note
The partner of BCL6 in this translocation is unknown.
Gene name
BCL6 (B-Cell Lymphoma 6)
Location
3q27.3
Protein description
706 amino acids; composed of a NH2-term BTB/POZ domain (amino acids 1-130 (32-99 according to Swiss-Prot) which mediates homodimerization and protein-protein interactions with other corepressors (including HDAC1 and NCOR2/SMRT to constitute a large repressing complex, another transcription repression domain (191-386), PEST sequences (300-417) with a KKYK motif (375-379), and six zinc finger at the C-term (518-541, 546-568, 574-596, 602-624, 630-652, 658-681), responsible for sequence specific DNA binding. Transcription repressor; recognizes the consensus sequence: TTCCT(A/C)GAA (Albagli-Curiel, 2003). Role in germinal centers of lymphoid follicles. BCL6 prevents ATM and TP53 to induce apoptosis in response to DNA rearrangements such as somatic hypermutation and class switch recombination. Therefore essential for normal B cell development.
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35640966 | 2022 | BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis. | 181 |
| 39456751 | 2024 | B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and Beyond. | 158 |
| 33663954 | 2021 | Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (T(FH)). | 127 |
| 36166198 | 2022 | B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral Immunity to Oncogenic Driver in Pediatric Cancers. | 102 |
| 37967194 | 2023 | MKL/SRF and Bcl6 mutual transcriptional repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoA. | 95 |
| 31788471 | 2019 | Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation. | 81 |
| 23725655 | 2013 | New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes. | 79 |
| 24698494 | 2014 | Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis. | 75 |
| 38337096 | 2024 | Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis. | 73 |
| 34625792 | 2021 | Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma. | 70 |
| 38688934 | 2024 | Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses. | 69 |
| 36651876 | 2023 | Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s. | 68 |
| 35503721 | 2022 | The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress. | 68 |
| 31980486 | 2020 | Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation. | 65 |
| 35766181 | 2022 | Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6-dependent pathway. | 64 |
| 27881582 | 2017 | The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target. | 63 |
| 34464595 | 2021 | BCL6 controls contact-dependent help delivery during follicular T-B cell interactions. | 61 |
| 36377663 | 2022 | BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer. | 61 |
| 33393503 | 2021 | BCL6 confers KRAS-mutant non-small-cell lung cancer resistance to BET inhibitors. | 61 |
| 24879792 | 2014 | BCL6 controls Th9 cell development by repressing Il9 transcription. | 61 |
| 32911532 | 2021 | BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells. | 60 |
| 26876184 | 2016 | Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation. | 60 |
| 18452090 | 2008 | Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas. | 59 |
| 32477338 | 2020 | Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis. | 59 |
| 37227491 | 2023 | The regulation of Tfh cell differentiation by β-hydroxybutyrylation modification of transcription factor Bcl6. | 58 |
| 29072703 | 2017 | BCL6 attenuates renal inflammation via negative regulation of NLRP3 transcription. | 57 |
| 31395741 | 2019 | Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia. | 52 |
| 39841144 | 2025 | BCL6 coordinates muscle mass homeostasis with nutritional states. | 51 |
| 25824819 | 2015 | BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms. | 47 |
| 34698105 | 2021 | Evaluation of BCL6 and SIRT1 as Non-Invasive Diagnostic Markers of Endometriosis. | 47 |
| 33208943 | 2020 | Small-molecule-induced polymerization triggers degradation of BCL6. | 45 |
| 28356518 | 2017 | BCL6 promotes glioma and serves as a therapeutic target. | 45 |
| 36076940 | 2022 | miRNA-10a-5p Targeting the BCL6 Gene Regulates Proliferation, Differentiation and Apoptosis of Chicken Myoblasts. | 43 |
| 35100079 | 2022 | miR-30b-5p inhibits osteoblast differentiation through targeting BCL6. | 41 |
| 37060074 | 2023 | The malignancy suppression and ferroptosis facilitation of BCL6 in gastric cancer mediated by FZD7 repression are strengthened by RNF180/RhoC pathway. | 40 |
| 24571259 | 2014 | LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma. | 39 |
| 37373354 | 2023 | Unveiling the Prognostic Significance of BCL6+/CD10+ Mantle Cell Lymphoma: Meta-Analysis of Individual Patients and Systematic Review. | 35 |
| 33807449 | 2021 | High-Grade B-Cell Lymphoma (HGBL) with MYC and BCL2 and/or BCL6 Rearrangements Is Predominantly BCL6-Rearranged and BCL6-Expressing in Taiwan. | 35 |
| 34135058 | 2021 | Bcl6-Independent In Vivo Development of Functional Type 1 Classical Dendritic Cells Supporting Tumor Rejection. | 31 |
| 35436984 | 2022 | B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36. | 30 |
| 22025499 | 2011 | Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks. | 29 |
| 38937822 | 2024 | Characteristics and Clinical Value of MYC , BCL2, and BCL6 Rearrangement Detected by Next-generation Sequencing in DLBCL. | 27 |
| 39419175 | 2025 | A positive ReceptivaDx result for BCL6 does not correlate with abnormal ERA results or decreased expression of receptivity-associated markers: two sides of the endometrial receptivity coin in fertility evaluation and treatment. | 27 |
| 38184753 | 2024 | Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential. | 26 |
| 36412101 | 2022 | BCL6-SPECC1L: A Novel Fusion Gene in Nasopharyngeal Carcinoma. | 25 |
| 35497498 | 2022 | BTB(BCL6) dimers as building blocks for reversible drug-induced protein oligomerization. | 23 |
| 36793435 | 2023 | Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor. | 21 |
| 35653645 | 2022 | Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo. | 20 |
| 19628815 | 2009 | Bcl6 mediates the development of T follicular helper cells. | 19 |
| 28929458 | 2018 | Backbone resonance assignment of the BCL6-BTB/POZ domain. | 10 |
| 22500840 | 2012 | Roles of BCL6 in normal and transformed germinal center B cells. | 0 |
| 28930682 | 2017 | Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. | 0 |
| 38335269 | 2024 | BCL6 is required for the thymic development of TCRαβ(+)CD8αα(+) intraepithelial lymphocyte lineage. | 0 |
| 38761804 | 2024 | Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation. | 0 |
| 38419581 | 2024 | BCL6 attenuates hyperoxia-induced lung injury by inhibiting NLRP3-mediated inflammation in fetal mouse. | 0 |
| 35125178 | 2022 | Predicting implantation failure: to BCL6 or not to BCL6. | 0 |
| 38289985 | 2024 | Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress. | 0 |
| 29262721 | 2018 | BCL6 as a therapeutic target for lymphoma. | 0 |
| 37556508 | 2023 | Targeting BCL6 in Gastrointestinal Stromal Tumor Promotes p53-Mediated Apoptosis to Enhance the Antitumor Activity of Imatinib. | 0 |
| 21083654 | 2011 | The role of BCL6 in lymphomas and routes to therapy. | 0 |
| 39208743 | 2024 | Discovery of novel BCL6-Targeting PROTACs with effective antitumor activities against DLBCL in vitro and in vivo. | 0 |
| 26566802 | 2015 | Mechanisms of action of BCL6 during germinal center B cell development. | 0 |
| 26108407 | 2015 | Mutual interaction between BCL6 and miRNAs contributing to the pathogenesis of various cancers. | 0 |
| 36441945 | 2022 | B-cell Lymphoma 6 Inhibitors: Current Advances and Prospects of Drug Development for Diffuse Large B-cell Lymphomas. | 0 |
| 38734343 | 2024 | BCL6 is a context-dependent mediator of the glioblastoma response to irradiation therapy. | 0 |
| 39716366 | 2025 | BCL6 Promotes Transcription of GPR61 to Suppress IL-1β-Induced Osteoarthritis Progression in C28/I2 Cells. | 0 |
| 16019457 | 2005 | Targeted somatic mutation of the BCL6 proto-oncogene and its impact on lymphomagenesis. | 0 |
| 39102989 | 2024 | BCL6 confers resistance to HDAC inhibitors in DLBCL. | 0 |
| 31732165 | 2019 | The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility. | 0 |
| 38452514 | 2024 | Epidermal loss of Bcl6 exacerbates MC903-induced atopic dermatitis-like skin inflammation. | 0 |
| 15024721 | 2004 | Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma. | 0 |
| 34774129 | 2022 | Structural basis of Apt48 inhibition of the BCL6 BTB domain. | 0 |
| 9373196 | 1997 | Significance of rearrangement of the BCL6 gene in B-cell lymphoid neoplasms. | 0 |
| 16815642 | 2007 | The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis. | 0 |
| 10953971 | 2000 | Internal deletions within the BCL6 gene in B-cell non-Hodgkin's lymphoma. | 0 |
| 20510734 | 2010 | BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis. | 0 |
| 17142954 | 2006 | Pathogenetic and clinical implications of non-immunoglobulin ; BCL6 translocations in B-cell non-Hodgkin's lymphoma. | 0 |
| 35297566 | 2022 | Clinicopathological analysis of follicular lymphoma with BCL2, BCL6, and MYC rearrangements. | 0 |
| 39387112 | 2025 | A Small-Molecule BCL6 Inhibitor as an Anti-Proliferative Agent for Diffuse Large B-Cell Lymphoma. | 0 |
| 37634473 | 2023 | A small molecule BCL6 inhibitor as chemosensitizers in acute myeloid leukemia. | 0 |
| 34698964 | 2022 | FX1, a BCL6 inhibitor, reactivates BCL6 target genes and suppresses HTLV-1-infected T cells. | 0 |
| 38178593 | 2024 | Hypoxic stress caused apoptosis of MDBK cells by p53/BCL6-mitochondrial apoptosis pathway. | 0 |
| 12389616 | 2002 | Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications. | 0 |
| 12659862 | 2003 | Bcl6-dependent transcriptional repression by BAZF. | 0 |
| 25597995 | 2015 | Bcl6 promotes osteoblastogenesis through Stat1 inhibition. | 0 |
| 26319027 | 2016 | A Novel Non-Immunoglobulin (non-Ig)/BCL6 Translocation in Diffuse Large B-Cell Lymphoma Involving Chromosome 10q11.21 Loci and Review on Clinical Consequences of BCL6 Rearrangements. | 0 |
| 27921272 | 2017 | BCL6 locus is hypermethylated in angioimmunoblastic T-cell lymphoma. | 0 |
| 37279329 | 2023 | Foxp3 and Bcl6 deficiency synergistically induces spontaneous development of atopic dermatitis-like skin disease. | 0 |
| 33189730 | 2021 | Inhibition of the BCL6/miR-31/PKD1 axis attenuates oxidative stress-induced neuronal damage. | 0 |
| 38648564 | 2024 | Testing for t(3;8) in MYC/BCL6-rearranged large B-cell lymphoma identifies a high-risk subgroup with inferior survival. | 0 |
| 29397940 | 2018 | KSHV vIRF4 enhances BCL6 transcription via downregulation of IRF4 expression. | 0 |
| 35357654 | 2022 | BCL6 and the Notch pathway: a signaling axis leading to a novel druggable biotarget in triple negative breast cancer. | 0 |
| 31346987 | 2019 | Bcl6 Suppresses Cardiac Fibroblast Activation and Function via Directly Binding to Smad4. | 0 |
| 27856253 | 2017 | Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship. | 0 |
| 12402037 | 2002 | Acetylation inactivates the transcriptional repressor BCL6. | 0 |
| 29972264 | 2019 | Bcl6 knockdown aggravates hypoxia injury in cardiomyocytes via the P38 pathway. | 0 |
| 34990752 | 2022 | An orally available small molecule BCL6 inhibitor effectively suppresses diffuse large B cell lymphoma cells growth in vitro and in vivo. | 0 |
| 11796228 | 2002 | Regulation of gene expression by the proto-oncogene BCL-6. | 0 |
| 7587061 | 1994 | BCL-6 and the molecular pathogenesis of B-cell lymphoma. | 0 |
| 33147467 | 2020 | Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12555064 | 2003 | Ambivalent role of BCL6 in cell survival and transformation. | Albagli-Curiel O et al |
| 11516111 | 2001 | Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin's lymphoma by interphase fluorescence in situ hybridization. | Sanchez-Izquierdo D et al |
| 3315179 | 1987 | Initial and subsequent cytogenetic studies in malignant lymphoma. | Sanger WG et al |
Citation
Jean-Loup Huret
t(3;6)(q27;q15) ?/BCL6
Atlas Genet Cytogenet Oncol Haematol. 2012-11-01
Online version: http://atlasgeneticsoncology.org/haematological/1626/t(3;6)(q27;q15)-bcl6
