| Clinics and Pathology |
| Disease | Acute myeloid leukemia (AML) |
| Epidemiology | Three patients to date, a 9-year-old girl with M4-AML, a 48-year-old male patient with M5-AML, and a 74-year-old female patient with therapy related AML(t-AML), M1 subtype, having occurred after treatment of a breast cancer (Haltrich et al., 2006; Charrin et al., 2002; Lindvall et al., 2001). |
| Prognosis | No individual data. |
| Genetics |
| Genes involved in this translocation are unknown. |
| Cytogenetics |
| Cytogenetics Morphological | The M5-AML and the t-AML cases also had a del(5q), and numerical anomalies; the M5-AML case had a marker chromosome and the t-AML case a very complex karyotype. |
| External links |
| Other database | t(3;8)(q21;q24) in myeloid malignancies | Mitelman database (CGAP - NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Molecular cytogenetic characterization of acute myeloid leukemia and myelodysplastic syndromes with multiple chromosome rearrangements. |
| Lindvall C, Nordenskjold M, Porwit A, Bjorkholm M, Blennow E. |
| Haematologica. 2001 Nov;86(11):1158-64. |
| PMID 11694401 |
| Structural rearrangements of chromosome 3 in 57 patients with acute myeloid leukemia: clinical, hematological and cytogenetic features. |
| Charrin C, Belhabri A, Treille-Ritouet D, Theuil G, Magaud JP, Fiere D, Thomas X. |
| Hematol J. 2002;3(1):21-31. |
| PMID 11960392 |
| Multipoint interphase FISH analysis of chromosome 3 abnormalities in 28 childhood AML patients. |
| Haltrich I, Kost-Alimova M, Kovacs G, Klein G, Fekete G, Imreh S. |
| Eur J Haematol. 2006 Feb;76(2):124-33. |
| PMID 16405433 |
| Contributor(s) |
| Written | 06-2008 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(3;8)(q21;q24) in myeloid malignancies. Atlas Genet Cytogenet Oncol Haematol. June 2008 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0308q21q24ID1249.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/44500/1/06-2008-t0308q21q24ID1249.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Mar 9 12:37:01 CET 2013 |
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