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t(3;8)(q21;q24) in myeloid malignancies

Written2008-06Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1249

Clinics and Pathology

Disease Acute myeloid leukemia (AML)
Epidemiology Three patients to date, a 9-year-old girl with M4-AML, a 48-year-old male patient with M5-AML, and a 74-year-old female patient with therapy related AML(t-AML), M1 subtype, having occurred after treatment of a breast cancer (Haltrich et al., 2006; Charrin et al., 2002; Lindvall et al., 2001).
Prognosis No individual data.

Genetics

Genes involved in this translocation are unknown.

Cytogenetics

Cytogenetics Morphological The M5-AML and the t-AML cases also had a del(5q), and numerical anomalies; the M5-AML case had a marker chromosome and the t-AML case a very complex karyotype.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Structural rearrangements of chromosome 3 in 57 patients with acute myeloid leukemia: clinical, hematological and cytogenetic features.
Charrin C, Belhabri A, Treille-Ritouet D, Theuil G, Magaud JP, Fiere D, Thomas X.
Hematol J. 2002;3(1):21-31.
PMID 11960392
 
Multipoint interphase FISH analysis of chromosome 3 abnormalities in 28 childhood AML patients.
Haltrich I, Kost-Alimova M, Kovacs G, Klein G, Fekete G, Imreh S.
Eur J Haematol. 2006 Feb;76(2):124-33.
PMID 16405433
 
Molecular cytogenetic characterization of acute myeloid leukemia and myelodysplastic syndromes with multiple chromosome rearrangements.
Lindvall C, Nordenskjold M, Porwit A, Bjorkholm M, Blennow E.
Haematologica. 2001 Nov;86(11):1158-64.
PMID 11694401
 

Citation

This paper should be referenced as such :
Huret, JL
t(3;8)(q21;q24) in myeloid malignancies
Atlas Genet Cytogenet Oncol Haematol. 2009;13(6):444-444.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0308q21q24ID1249.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;8)(q21;q24) in myeloid malignancies

External links

Mitelman databaset(3;8)(q21;q24) [Case List]    t(3;8)(q21;q24) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(3;8)(q21;q24) in myeloid malignancies
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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