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t(3;11)(q26;p15) ?/MECOM

Written2007-05Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
Atlas_Id 1474

Clinics and Pathology

Disease Chronic myelogenous leukaemia with t(9;22)(q34;q11)
Epidemiology Only one case to date, a 64 year old male patient
Prognosis No data

Cytogenetics

Cytogenetics Morphological Anomaly accompanying the t(9;22)(q34;q11)

Genes involved and Proteins

Note The partner of EVI1 is yet unknown.
Gene Name MECOM
Location 3q26.2
Protein Transcrition factor; EVI1 targets include:GATA2, ZBTB16 /PLZF, ZFPM2/FOG2, JNK and the PI3K/AKT pathway. Role in cell cycle progression, likely to be cell-type dependant; antiapoptotic factor; involved in neuronal development organogenesis; role in hematopoietic differsntiation

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

EVI1 is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements.
Poppe B, Dastugue N, Vandesompele J, Cauwelier B, De Smet B, Yigit N, De Paepe A, Cervera J, Recher C, De Mas V, Hagemeijer A, Speleman F
Genes, chromosomes & cancer. 2006 ; 45 (4) : 349-356.
PMID 16342172
 
The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions.
Wieser R
Gene. 2007 ; 396 (2) : 346-357.
PMID 17507183
 

Citation

This paper should be referenced as such :
Huret, JL
t(3;11)(q26;p15)
Atlas Genet Cytogenet Oncol Haematol. 2008;12(1):60-60.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0311q26p15ID1474.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;11)(q26;p15) ?/MECOM

External links

Mitelman databaset(3;11)(q26;p15) [Case List]    t(3;11)(q26;p15) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9975/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(3;11)(q26;p15) ?/MECOM
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Sat Jan 21 16:49:53 CET 2017


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