BCL6 (B-Cell Lymphoma 6)

3q27.3

706 amino acids; composed of a NH2-term BTB/POZ domain (amino acids 1-130 (32-99 according to Swiss-Prot) which mediates homodimerization and protein-protein interactions with other corepressors (including HDAC1 and NCOR2/SMRT ) to constitute a large repressing complex, another transcription repression domain (191-386), PEST sequences (300-417) with a KKYK motif (375-379), and six zinc finger at the C-term (518-541, 546-568, 574-596, 602-624, 630-652, 658-681), responsible for sequence specific DNA binding. Transcription repressor; recognizes the consensus sequence: TTCCT(A/C)GAA (Albagli-Curiel, 2003).

GAPDH (glyceraldehyde-3-phosphate dehydrogenase)

12p13.31

335 amino acids; possess a nucleotide binding site for NAD+, and sites for glyceraldehyde 3-phosphate binding; catalyzes the phosphorylation and oxidation of glyceraldehyde-3-phosphate to 1,3-biphosphoglycerate (interconversion), using NAD+ as electron acceptor. Role in endocytosis and in nuclear membrane assembly. Associates with microtubules and RAB2, which stimulates the recruitment of dynein, to regulates microtubule motility and cargo transport. Also binds mRNA and t-RNA; may participate in tRNA export and mRNA stability. Role in the cell cycle, in DNA repair, and in apoptosis associated with oxidative stress (reviews in Sirover, 1999; Hara and Snyder, 2006; Hara et al., 2006; Colell et al., 2009).