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t(3;13)(q27;q14) LCP1/BCL6

Written1998-01Jean-Loup Huret and Jean-Luc Laï

(Note : for Links provided by Atlas : click)

Identity

Atlas_Id 2053
 
  t(3,13)(q27; q14-21), t(14;18;(q32;q21) G - banding - Courtesy Jean-Luc Lai

Clinics and Pathology

Disease NHL
Phenotype / cell stem origin found in various types of NHL (e.g. Burkitt's lymphoma andfollicular lymphoma); the translocation is therefore likely to be a secondary event in the course of the disease.
Epidemiology only 3 cases available to date; all three are adult female patients

Cytogenetics

Cytogenetics Morphological found twice (out of three occurrence) as a secondary anomaly: following the well known t(8;14)(q24;q32) and t(14;18)(q32;q21)
Additional anomalies del(6q) found in 2 of 3 cases; the karyotype may be complex

Genes involved and Proteins

Gene NameBCL6 (B-Cell Lymphoma 6)
Location 3q27.3
Gene NameLCP1 (lymphocyte cytosolic protein1)
Location 13q14.13

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Translocation (3;13)(q27;q14): a nonrandom and probably secondary structural change in non-Hodgkin lymphomas.
Laï JL, Daudignon A, Kerckaert JP, Galiègue-Zouitina S, Detourmignies L, Morel P, Bauters F, Fenaux P
Cancer genetics and cytogenetics. 1998 ; 103 (2) : 140-143.
PMID 9614913
 

Citation

This paper should be referenced as such :
Huret JL and Laï JL
t(3;13)(q27;q14) LCP1/BCL6;
Atlas Genet Cytogenet Oncol Haematol. in press
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0313ID2053.html


Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes BCL6 LCP1

Translocations implicated (Data extracted from papers in the Atlas)

 t(3;13)(q27;q14) LCP1/BCL6

External links

arrayMap (UZH-SIB Zurich)

Mitelman databaset(3;13)(q27;q14) [Case List]    t(3;13)(q27;q14) [Association List] Mitelman database (CGAP - NCBI)
arrayMap[select an item]
 
 
Disease databaset(3;13)(q27;q14) LCP1/BCL6
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Sep 18 17:19:25 CEST 2017


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