t(3;16)(q21;q22)
2008-11-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Myeloid disorders: myelodysplastic syndromes (MDS) and acute myeloid leukaemias (AML)
Phenotype stem cell origin
The AML case was a myelomonocytic leukaemia (M4-AML) with eosinophilia; one of the the MDS cases also showed bone marrow eosinophilia. One MDS case was treatment related (t-MDS), the first tumour was a mantle cell lymphoma.
Epidemiology
Only 3 cases to date, 1 male and 2 female patients, aged 47, 59, and 63 years (Neri et al., 1985; Bernard et al., 1989; Olney et al., 2002).
Genes Involved and Proteins
Note
The genes involved are unknown; because of the eosinophilia in at least 2 of 3 patients, it is likely that the gene involved in 16q22 is CBFB.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 2779289 | 1989 | Acute nonlymphocytic leukemia with marrow eosinophilia and chromosome 16 abnormality: a report of 18 cases. | Bernard P et al |
| 3967211 | 1985 | Chromosome 16q, eosinophilia, and leukemia. | Neri G et al |
| 11921275 | 2002 | Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop. | Olney HJ et al |
Citation
Jean-Loup Huret
t(3;16)(q21;q22)
Atlas Genet Cytogenet Oncol Haematol. 2008-11-01
Online version: http://atlasgeneticsoncology.org/haematological/1088/t(3;16)(q21;q22)
