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t(3;19)(q27;q13) NAPA/BCL6

Written2012-06Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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Atlas_Id 2130

Clinics and Pathology

Disease Non Hodgkin lymphoma
Clinics Two cases available : a case of follicular lymphoma transformed to diffuse aggressive lymphoma, from a study with no individual data (Akasaka et al., 2003), and a male patient aged 60 years with a diffuse large B-cell lymphoma (Yunis et al., 1984).


Additional anomalies The case described by Yunis et al., 1984 showed a complex karyotype.

Genes involved and Proteins

Note Only the more recent case (Akasaka et al., 2003) was studied for gene rearrangements.
Gene NameBCL6 (B-Cell Lymphoma 6)
Location 3q27.3
Protein 706 amino acids; composed of a NH2-term BTB/POZ domain (amino acids 1-130 (32-99 according to Swiss-Prot) which mediates homodimerization and protein-protein interactions with other corepressors (including HDAC1 and NCOR2/SMRT to constitute a large repressing complex, another transcription repression domain (191-386), PEST sequences (300-417) with a KKYK motif (375-379), and six zinc finger at the C-term (518-541, 546-568, 574-596, 602-624, 630-652, 658-681), responsible for sequence specific DNA binding. Transcription repressor; recognizes the consensus sequence: TTCCT(A/C)GAA (Albagli-Curiel, 2003). Role in germinal centers of lymphoid follicles. BCL6 prevents ATM and TP53 to induce apoptosis in response to DNA rearrangements such as somatic hypermutation and class switch recombination. Therefore essential for normal B cell development.
Gene NameNAPA (N-ethylmaleimide-sensitive factor attachment protein, alpha)
Location 19q13.32
Protein 295 amino acids; SNARE protein found in the endoplasmic reticulum and implicated in protein trafficking, which possesses anti-apoptotic properties by promoting resistance to cisplatin in cancer cells by inducing the degradation of TP53 (Wu et al., 2011).

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.
Akasaka T, Lossos IS, Levy R.
Blood. 2003 Aug 15;102(4):1443-8. Epub 2003 May 8.
PMID 12738680
Ambivalent role of BCL6 in cell survival and transformation.
Albagli-Curiel O.
Oncogene. 2003 Jan 30;22(4):507-16.
PMID 12555064
Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation.
Wu ZZ, Sun NK, Chien KY, Chao CC.
Biochem Pharmacol. 2011 Dec 1;82(11):1630-40. Epub 2011 Aug 31.
PMID 21903092
Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma.
Yunis JJ, Oken MM, Theologides A, Howe RB, Kaplan ME.
Cancer Genet Cytogenet. 1984 Sep;13(1):17-28.
PMID 6467179


This paper should be referenced as such :
Huret, JL
t(3;19)(q27;q13) NAPA/BCL6
Atlas Genet Cytogenet Oncol Haematol. 2012;16(12):924-924.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 1 ]

Genes BCL6

Translocations implicated (Data extracted from papers in the Atlas)

 t(3;19)(q27;q13) NAPA/BCL6

External links

NAPA (19q13.32) BCL6 (3q27.3)

NAPA (19q13.32) BCL6 (3q27.3)

Mitelman databaset(3;19)(q27;q13)
arrayMap (UZH-SIB Zurich)[select an item]
Mitelman databaseNAPA/BCL6 [MCList]  NAPA (19q13.32) BCL6 (3q27.3)
Mitelman databaseNAPA/BCL6 [MCList]  NAPA (19q13.32) BCL6 (3q27.3)
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