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t(4;5)(q31;q31)

Written2008-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1206

Clinics and Pathology

Disease Myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML)
Phenotype / cell stem origin The AML case was a M6
Epidemiology Only three cases available; patients (one male, two female patients) were aged 68, 70, and 80 (yrs).

Cytogenetics

Cytogenetics Morphological The 3 cases were found using multi-FISH techniques; this translocation may therefore be partially cryptic, especially so as it is found in complex karyotypes.
Additional anomalies Major karyotypic anomalies were present in 3 out of 3 cases; +X and +8 were found in one case.

Genes involved and Proteins

Note Genes involved are unknown.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.
Van Limbergen H, Poppe B, Michaux L, Herens C, Brown J, Noens L, Berneman Z, De Bock R, De Paepe A, Speleman F
Genes, chromosomes & cancer. 2002 ; 33 (1) : 60-72.
PMID 11746988
 
Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping.
Veldman T, Vignon C, Schröck E, Rowley JD, Ried T
Nature genetics. 1997 ; 15 (4) : 406-410.
PMID 9090389
 

Citation

This paper should be referenced as such :
Huret, JL
t(4;5)(q31;q31)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(2):139-139.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0405q31q31ID1206.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(4;5)(q31;q31)

External links

Mitelman databaset(4;5)(q31;q31) [Case List]    t(4;5)(q31;q31) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9989/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(4;5)(q31;q31)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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