| Clinics and Pathology |
| Disease | T-cell acute lymphoblastic leukemia (T-ALL) |
| Epidemiology | only one case to date, a 12 yr old male patient |
| Prognosis | unknown |
| Cytogenetics |
| Cytogenetics Morphological | a del(7q) was also present in the same clone |
| Genes involved and Proteins |
| Note | The gene in 4q31 is yet unknown, and, because cryptic t(12;21) ETV6 /AML1 are not rare, it is therefore uncertain whether this translocation involve a new AML1 partner |
| Gene Name | AML1 |
| Location | 21q22 |
| Dna / Rna | transcription is from telomere to centromere |
| Protein | contains a Runt domain and, in the C-term, a transactivation domain; forms heterodimers; widely expressed; nuclear localisation; transcription factor (activator) for various hematopoietic-specific genes |
| External links |
| Other database | t(4;21)(q31;q22) | Mitelman database (CGAP - NCBI) | |
| Other database | t(4;21)(q31;q22) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia. |
| Mathew S, Shurtleff SA, Raimondi SC |
| Genes, chromosomes & cancer. 2001 ; 32 (2) : 188-193. |
| PMID 11550288 |
| A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia. |
| Mikhail FM, Serry KA, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, Coignet L, Nucifora G |
| Cancer genetics and cytogenetics. 2002 ; 135 (1) : 96-100. |
| PMID 12072207 |
| Contributor(s) |
| Written | 02-2003 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(4;21)(q31;q22). Atlas Genet Cytogenet Oncol Haematol. February 2003 . URL : http://AtlasGeneticsOncology.org/Genes/t0421q31q22ID1262.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Aug 11 21:20:09 2008 |
For comments and suggestions or contributions, please contact us