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t(5;15)(p15;q11)

Written1999-03Nyla A. Heerema
The Ohio State University, Division of Clinical Pathology, Department of Pathology, 167 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210, USA

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
Atlas_Id 1149

Clinics and Pathology

Disease B-cell, precursor ALL
Phenotype / cell stem origin L1, CD10+/-, CD24+
Epidemiology 5 reported cases; Infant ALL, age 1.5-7 months at diagnosis
Prognosis CR in all cases; 1 CNS relapse

Cytogenetics

Cytogenetics Morphological t(5;15)(p15;q11-13)
Cytogenetics Molecular not done
Additional anomalies +14; +22 one case each
Variants none reported

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer Group.
Heerema NA, Arthur DC, Sather H, Albo V, Feusner J, Lange BJ, Steinherz PG, Zeltzer P, Hammond D, Reaman GH
Blood. 1994 ; 83 (8) : 2274-2284.
PMID 8161794
 

Citation

This paper should be referenced as such :
Heerema, NA
t(5;15)(p15;q11-13)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):85-85.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0515ID1149.html

Translocations implicated (Data extracted from papers in the Atlas)

 t(5;15)(p15;q11)

External links

Mitelman databaset(5;15)(p15;q11) [Case List]    t(5;15)(p15;q11) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9811/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(5;15)(p15;q11)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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