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Written2008-03Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1151

Clinics and Pathology

Disease Acute myeloid leukemia (AML)
Epidemiology Only two cases to date, a 10-month-old male infant with M4-AML, who entered remission, and a 60-year-old male patient with M1-AML who died 4 months after diagnosis. Both patients presented with marked eosinophilia (Bhambhani et al., 1986; Sanada et al., 1989).


Cytogenetics Morphological The t(5;16)(q33;q22) was the sole anomaly in both cases.

Genes involved and Proteins

Note Genes involved in this structural anomaly are unknown, although it is likely that CBFb is involved in the disease.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Acute myelomonocytic leukemia type M4 with bone marrow eosinophilia and t(5;16)(q33;q22).
Bhambhani K, Inoue S, Tyrkus M, Gohle N.
Cancer Genet Cytogenet. 1986 Feb 1;20(1-2):187-8.
PMID 3455859
Acute myelogenous leukemia (FAB M1) associated with t(5;16) and eosinophilia. Report of an additional case.
Sanada I, Asou N, Kojima S, Kawano F, Shido T, Takatsuki K.
Cancer Genet Cytogenet. 1989 Nov;43(1):139-41.
PMID 2790769


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2009;13(3):239-239.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databaset(5;16)(q33;q22)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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