| Clinics and Pathology |
| Disease | Acute myeloid leukemia (AML) |
| Epidemiology | Only two cases to date, a 10-month-old male infant with M4-AML, who entered remission, and a 60-year-old male patient with M1-AML who died 4 months after diagnosis. Both patients presented with marked eosinophilia (Bhambhani et al., 1986; Sanada et al., 1989). |
| Cytogenetics |
| Cytogenetics Morphological | The t(5;16)(q33;q22) was the sole anomaly in both cases. |
| Genes involved and Proteins |
| Note | Genes involved in this structural anomaly are unknown, although it is likely that CBFb is involved in the disease. |
| External links |
| Other database | t(5;16)(q33;q22) | Mitelman database (CGAP - NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Acute myelomonocytic leukemia type M4 with bone marrow eosinophilia and t(5;16)(q33;q22). |
| Bhambhani K, Inoue S, Tyrkus M, Gohle N. |
| Cancer Genet Cytogenet. 1986 Feb 1;20(1-2):187-8. |
| PMID 3455859 |
| Acute myelogenous leukemia (FAB M1) associated with t(5;16) and eosinophilia. Report of an additional case. |
| Sanada I, Asou N, Kojima S, Kawano F, Shido T, Takatsuki K. |
| Cancer Genet Cytogenet. 1989 Nov;43(1):139-41. |
| PMID 2790769 |
| Contributor(s) |
| Written | 03-2008 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(5;16)(q33;q22). Atlas Genet Cytogenet Oncol Haematol. March 2008 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0516q33q22ID1151.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/44439/1/03-2008-t0516q33q22ID1151.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Mar 9 12:37:18 CET 2013 |
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