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t(6;7)(p25.3;q32.3) DUSP22/FRA7H

Written2013-05Sarah H Johnson, George Vasmatzis, Andrew L Feldman
Center for Individualized Medicine - Biomarker Discovery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA (SHJ; GV); Department of Laboratory Medicine, Pathology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA (ALF)

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Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 1579

Clinics and Pathology

Disease ALK-negative anaplastic large cell lymphoma; primary cutaneous anaplastic large cell lymphoma
Phenotype / cell stem origin Mature (peripheral) T cell (most cases); occasional cases are of uncertain lineage (so-called "null cell" type).
Etiology No etiologic factors are known.
Epidemiology All reported cases have occurred in adults. Estimated frequency of t(6;7)(p25.3;q32.3) in ALK-negative ALCL (systemic or cutaneous) is 10% (13 of 125 ALK-negative ALCLs tested) (Feldman et al., 2011). Additional cases with rearrangements of 6p25.3 not involving 7q32.3 also have been reported.
Clinics Presentation has not been shown to differ significantly from other ALCLs; i.e. systemic ALK-negative ALCLs typically present with lymphadenopathy and/or extranodal tissue involvement, whereas primary cutaneous ALCLs typically present with localized skin lesions and may develop locoregional lymph node involvement.
Pathology Pathologic findings are similar to those seen in systemic or primary cutaneous ALK-negative ALCL. Detection of t(6;7)(p25.3;q32.3) in ALK-positive ALCL has not been reported.
 
Primary cutaneous ALCL with t(6;7)(p25.3;q32.3). H&E stains at low (A) and high (B) magnification show a tumor-forming cellular infiltrate in the dermis of the skin. The tumor cells are medium-sized to large atypical lymphoid cells with a sheet-like growth pattern. By immunohistochemical stains, they are negative for CD20 (C), weakly positive for CD3 (D), strongly positive for CD30 (E), and negative for ALK (F).
Treatment Unknown.
Evolution Unknown.
Prognosis Unknown.

Cytogenetics

Cytogenetics Morphological Karyotypic findings have not been reported.
 
  Dual-fusion FISH demonstrating t(6;7)(p25.3;q32.3) in ALCL. Two tumor cells at left show fusions of the DUSP22-IRF4 locus on 6p25.3 (red) to 7q32.3 (green) (solid arrows). The folded or reniform configuration typical of ALCL nuclei ("hallmark" cells) can be seen. The open arrow at upper right points to a normal cell with round nuclear contours and lacking fusion signals.
Additional anomalies Unknown.
Variants Rearrangements of 6p25.3 with other partner loci have been reported.

Genes involved and Proteins

Gene Name DUSP22
Location 6p25.3
Dna / Rna In the single reported sequenced case, the translocation disrupted the DUSP22 gene within intron 1. FISH studies using probes covering different regions of the DUSP22-IRF4 locus on 6p25.3 showed that in other cases the breakpoint was centromeric to DUSP22 and closer to IRF4 (Feldman et al., 2011). Regardless of breakpoint location, gene expression studies showed up to a 50-fold reduction in expression of DUSP22 in the translocated cases compared to untranslocated cases. IRF4 expression was similar between translocated and untranslocated cases.
Protein DUSP22 encodes a dual-specificity phosphatase that inhibits T-cell antigen-receptor signaling in T cells by inactivating the MAP kinase, ERK2. Its function in ALCL has not been confirmed.
Gene Name FRA7H
Location 7q32.3
Dna / Rna The 7q32.3 breakpoint lies in the non-coding transcript region FLJ43663, immediately telomeric to the fragile site, FRA7H, and the microRNAs, MIR29A and MIR29B1.

Result of the chromosomal anomaly

Hybrid gene
Note None known.
  
Fusion Protein
Note None known.
  

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing.
Feldman AL, Dogan A, Smith DI, Law ME, Ansell SM, Johnson SH, Porcher JC, Ozsan N, Wieben ED, Eckloff BW, Vasmatzis G.
Blood. 2011 Jan 20;117(3):915-9. doi: 10.1182/blood-2010-08-303305. Epub 2010 Oct 28.
PMID 21030553
 

Citation

This paper should be referenced as such :
Johnson, SH ; Vasmatzis, G ; Feldman, AL
t(6;7)(p25.3;q32.3) DUSP22/FRA7H
Atlas Genet Cytogenet Oncol Haematol. 2013;17(11):770-772.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0607p25q32ID1579.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(6;7)(p25.3;q32.3) DUSP22/FRA7H

External links

arrayMap (UZH-SIB Zurich)
Mitelman databaset(6;7)(p25.3;q32.3) [Case List]    t(6;7)(p25.3;q32.3) [Association List] Mitelman database (CGAP - NCBI)
arrayMap[select an item]
 
 
Disease databaset(6;7)(p25.3;q32.3) DUSP22/FRA7H
REVIEW articlesautomatic search in PubMed
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