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t(6;12)(q15;p13)

Written2019-09Tatiana Gindina
R.M. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation at Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russian Federation / e-mail: tatgindina@gmail.com

Abstract Review on t(6;12)(q15;p13)

Keywords Chromosome 6; Chromosome 12; t(6;12)(q15;p13); Prolymphocytic leukemia

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424
ICD-Morpho 9833/3 B-cell prolymphocytic leukaemia
Atlas_Id 2046

Clinics and Pathology

Disease B-cell prolymphocytic leukemia
Etiology
Epidemiology Only 5 cases to date, 3 males and 2 females, all patients were over 65 years old (Sadamori et al., 1983).
Table 1. Reported cases with t(6;12)(q15;p13).
PtsAge, genderDisease

Karyotype
166,MB-prolymphocytic leukemia

48,XY,+add(1)(p36),+t(6;12)(q15;p13),t(6;6;14)(p21;q21;q32),+12,-13 
277,M43,X,-Y,+t(6;12)(q15;p13),-8,add(13)(q34),-17,-22 
369,M44,XY,-2,t(6;12)(q15;p13),-17
472,M43,X,-X,+t(6;12)(q15;p13),-8,-17,-18,-22,+mar 
587,M45,XX,t(5;16)(q22;p13),-6,t(6;12)(q15;p13),t(6;19)(p11;p13),-17,+r 
Prognosis No data.

Cytogenetics

Additional anomalies All five cases showed complex chromosome abnormalities. Four of the five cases were hypodiploid and displayed monosomy 17.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Possible specific chromosome change in prolymphocytic leukemia.
Sadamori N, Han T, Minowada J, Bloom ML, Henderson ES, Sandberg AA.
Blood. 1983; 19(4):729-736
PMID 6882921
 

Citation

This paper should be referenced as such :
Gindina T
t(6;12)(q15;p13);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0612q15p13ID2046.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(6;12)(q15;p13)


External links

Mitelman databaset(6;12)(q15;p13) [Case List]    t(6;12)(q15;p13) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Morph ( 9833/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
REVIEW articlesautomatic search in PubMed
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