Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA


Written2008-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
Atlas_Id 1484

Clinics and Pathology

Disease Myeloproliferative syndrome (MPD) and acute myeloid leukaemia (AML)
Phenotype / cell stem origin One case was a M2-AML, another case was a MPD associated with an AML, the third case was an AML not otherwise specified.
Epidemiology Only three cases available; two male and one female patients aged 62, 63, and 71 yrs.


Cytogenetics Morphological The 3 cases were found using multi-FISH techniques; this translocation may therefore be partially cryptic, especially so as it is found in complex karyotypes.
Additional anomalies The three cases present with very similar cytogenetic profiles: major karyotypic anomalies were present in 3 out of 3 cases; -5/del(5q) was found in the three cases, and +8 and -14 were found in two cases each.

Genes involved and Proteins

Note Genes involved are unknown.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Comparison of spectral karyotyping and conventional cytogenetics in 39 patients with acute myeloid leukemia and myelodysplastic syndrome.
Mohr B, Bornhäuser M, Thiede C, Schäkel U, Schaich M, Illmer T, Pascheberg U, Ehninger G
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (6) : 1031-1038.
PMID 10865969
Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.
Van Limbergen H, Poppe B, Michaux L, Herens C, Brown J, Noens L, Berneman Z, De Bock R, De Paepe A, Speleman F
Genes, chromosomes & cancer. 2002 ; 33 (1) : 60-72.
PMID 11746988
Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping.
Veldman T, Vignon C, Schröck E, Rowley JD, Ried T
Nature genetics. 1997 ; 15 (4) : 406-410.
PMID 9090389


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2009;13(2):140-140.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databaset(7;14)(q21;q13)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9975/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 7 15:07:47 CEST 2020

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us