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t(8;9)(q24;q13)

Written2009-05Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
Atlas_Id 1550

Clinics and Pathology

Disease Non Hodgkin lymphoma and acute lymphoblastic lymphoma.
Phenotype / cell stem origin B-cell malignancies.
Epidemiology 3 cases to date: a stage IIIA mantle cell lymphoma in a male aged 58 years (Au et al., 2000; Au et al., 2002), a follicular lymphoma in a female patient aged 44 years (Chen et al., 2001), and a pre-B acute lymphoblastic leukemia (ALL) in a female patient aged 60 years (Pedersen et al., 2001).
Evolution Clinical data is available in the mantle cell lymphoma case, who reached complete remission, relapsed 2 years later, and died.

Cytogenetics

Additional anomalies The mantle cell lymphoma case exhibited a complex karyotype with a t(11;14)(q13;q32), a t(9;14)(q13;q32) and other anomalies, the follicular lymphoma a t(1;14)(q21;q32), and the ALL case a complex karyotype, including +7, +12, add(14)(q32), and other anomalies. The follicular lymphoma case progressed towards a diffuse large cell lymphoma with a complex karyotype, including +7, +17, +19, i(6p) and other anomalies.

Genes involved and Proteins

Note In the follicular lymphoma case with t(1;14)(q21;q32), there was deregulation of FCGR2B expression due to FCGR2B/IgH juxtaposition

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Cytogenetic analysis in mantle cell lymphoma: a review of 214 cases.
Au WY, Gascoyne RD, Viswanatha DS, Connors JM, Klasa RJ, Horsman DE.
Leuk Lymphoma. 2002 Apr;43(4):783-91.
PMID 12153165
 
8q24 translocations in blastic transformation of mantle cell lymphoma.
Au WY, Horsman DE, Viswanatha DS, Connors JM, Klasa RJ, Gascoyne RD.
Haematologica. 2000 Nov;85(11):1225-7.
PMID 11064480
 
Deregulation of FCGR2B expression by 1q21 rearrangements in follicular lymphomas.
Chen W, Palanisamy N, Schmidt H, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Houldsworth J, Chaganti RS.
Oncogene. 2001 Nov 15;20(52):7686-93.
PMID 11753646
 
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results.
Pedersen RK, Kerndrup GB, Sorensen AG, Mourits-Andersen T, Gram-Hansen P, Pulczynski S, Schmidt KG.
Cancer Genet Cytogenet. 2001 Jul 1;128(1):7-10.
PMID 11454422
 

Citation

This paper should be referenced as such :
Huret, JL
t(8;9)(q24;q13)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(4):433-433.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0809q24q13ID1550.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(8;9)(q24;q13)

External links

Mitelman databaset(8;9)(q24;q13) [Case List]    t(8;9)(q24;q13) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9811/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(8;9)(q24;q13)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Nov 21 15:09:44 CET 2017


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jlhuret@AtlasGeneticsOncology.org.