| Disease | ANLL; t-ANLL |
| Phenotype / cell stem origin | M4, M5a, M5b; possible involvement of a granulo-monocytic precursor; no preceeding MDS |
| Epidemiology | rare disease (<1% of ANLL); found in children (including infants) and young adults of both sexes. |
| Clinics | disseminated intra vascular coagulation may be present; extramedullary infiltration; 20% of the cases could be therapy-related |
| Cytology | erythrophagocytosis, strong peroxidase and esterase activities |
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| The t(8;16) has been cloned and shown to fuse the MOZ (monocytic leukemia zinc finger) gene at 8p11.2 to the CBP (CREB binding protein) gene at 16p13.3. The MOZ gene has also been found to be involved in variant translocations t(8;19)(p11;q13) and t(8;22)(p11;q13) and inv(8)(p11q13) translocations associated with M5/M4 AML.This translocation is associated with AML M5/M4. In the majority of cases it is associated with features of hemophagocytosis by leukemic cells, particularly erythrophagocytosis - Courtesy Georges Flandrin, CD-ROM AML/MDS G.Flandrin/ICG. TRIBVN |
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| Prognosis | poor: remission may be obtained in half cases; infections, bleeding; survival is often less than 1yr but spontaneous remission has occurred (at least) once. |
| The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. |
| Borrow J, Stanton VP Jr, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubˆ© I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE |
| Nature genetics. 1996 ; 14 (1) : 33-41. |
| PMID 8782817 |
| |
| Spontaneous remission of congenital leukemia. |
| Dinulos JG, Hawkins DS, Clark BS, Francis JS |
| The Journal of pediatrics. 1997 ; 131 (2) : 300-303. |
| PMID 9290620 |
| |
| The 8p11 anomaly in monoblastic leukaemia. |
| Brizard A, Guilhot F, Huret JL, Benz-Lemoine E, Tanzer J |
| Leukemia research. 1988 ; 12 (8) : 693-697. |
| PMID 3184987 |
| |
| Therapy-related acute myeloid leukemia with t(8;21), inv(16), and t(8;16): a report on 25 cases and review of the literature. |
| Quesnel B, Kantarjian H, Bjergaard JP, Brault P, Estey E, Lai JL, Tilly H, Stoppa AM, Archimbaud E, Harousseau JL |
| Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1993 ; 11 (12) : 2370-2379. |
| PMID 8246025 |
| |
| A distinct subtype of M4/M5 acute myeloblastic leukemia (AML) associated with t(8:16)(p11:p13), in a patient with the variant t(8:19)(p11:q13)--case report and review of the literature. |
| Stark B, Resnitzky P, Jeison M, Luria D, Blau O, Avigad S, Shaft D, Kodman Y, Gobuzov R, Ash S |
| Leukemia research. 1995 ; 19 (6) : 367-379. |
| PMID 7596149 |
| |
| Translocation t(8;16)(p11;p13) in acute non-lymphocytic leukemia: report on two new cases and review of the literature. |
| Velloso ER, Mecucci C, Michaux L, Van Orshoven A, Stul M, Boogaerts M, Bosly A, Cassiman JJ, Van Den Berghe H |
| Leukemia & lymphoma. 1996 ; 21 (1-2) : 137-142. |
| PMID 8907281 |
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