| Written | 2003-07 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS |
| Atlas_Id | 1256 |
| Clinics and Pathology |
| Disease | Acute myeloid leukemia (AML) (M1 and M5 AML) and biphenotypic leukemia |
| Epidemiology | only 3 cases available so far; 2 male and 1 female patients, aged 2, 27, and 86 yrs |
| Prognosis | unknown (one case died at 1 mth, another one is alive at 74 mths +) |
| Genetics |
| genes involved are unknown |
| Cytogenetics |
| Additional anomalies | complex karyotypes were found in two of three cases, del(5q) and +8 in two cases each, -7 in one case |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Bone marrow karyotypes in 94 children with acute leukemia. |
| Heim S, Békássy AN, Garwicz S, Heldrup J, Kristoffersson U, Mandahl N, Wiebe T, Mitelman F |
| European journal of haematology. 1990 ; 44 (4) : 227-233. |
| PMID 2344885 |
| Translocation (X;10)(p10;p10): A rare but nonrandom chromosomal abnormality in acute leukemia of myeloid differentiation. |
| Wong KF, Hayes KJ, Huh YO, Albitar M, Glassman AB |
| Cancer genetics and cytogenetics. 1996 ; 86 (2) : 153-155. |
| PMID 8603344 |
| Citation |
| This paper should be referenced as such : |
| Huret, JL |
| t(X;10)(p10;p10) |
| Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):187-187. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t0X10p10p10ID1256.html |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(X;10)(p10;p10) | |
| External links |
| Mitelman database | t(X;10)(p10;p10) [Case List] t(X;10)(p10;p10) [Transloc-MCList] |
| arrayMap (UZH-SIB Zurich) | Topo ( C42) Morph ( 9861/3) - [auto + random 100 samples .. if exist ] [tabulated segments] |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 14 13:40:29 CEST 2018 |
For comments and suggestions or contributions, please contact us