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Written2003-07Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1256

Clinics and Pathology

Disease Acute myeloid leukemia (AML) (M1 and M5 AML) and biphenotypic leukemia
Epidemiology only 3 cases available so far; 2 male and 1 female patients, aged 2, 27, and 86 yrs
Prognosis unknown (one case died at 1 mth, another one is alive at 74 mths +)


genes involved are unknown


Additional anomalies complex karyotypes were found in two of three cases, del(5q) and +8 in two cases each, -7 in one case

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Bone marrow karyotypes in 94 children with acute leukemia.
Heim S, Békássy AN, Garwicz S, Heldrup J, Kristoffersson U, Mandahl N, Wiebe T, Mitelman F
European journal of haematology. 1990 ; 44 (4) : 227-233.
PMID 2344885
Translocation (X;10)(p10;p10): A rare but nonrandom chromosomal abnormality in acute leukemia of myeloid differentiation.
Wong KF, Hayes KJ, Huh YO, Albitar M, Glassman AB
Cancer genetics and cytogenetics. 1996 ; 86 (2) : 153-155.
PMID 8603344


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):187-187.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databaset(X;10)(p10;p10)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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