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t(X;11)(q21;q23) BRWD3/ARHGAP20

Written2006-08Claudia Kalla
DKFZ, Div. Molecular Genetics (B060), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 1430
Other namesOriginally, this translocation had been published as t(X;11)(q13;23), before BRWD3 was re-mapped to Xq21.1.

Clinics and Pathology

Disease B-cell chronic lymphocytic leukemia (B-CLL)
Epidemiology Only one case reported to date. In a second B-CLL case, a variant translocation t(11;13)(q23;q14) rearranged the same gene on 11q23 with another partner.

Cytogenetics

 
  Dual-color interphase FISH analysis of the 11q23 and Xq21 breakpoints with BAC clones.
(A) FISH analysis with 11q23 specific BACs: RP11-468P24 (red signals) and RP11-206G12 (green signals). Three red signals indicate translocation within the genomic region represented by RP11-468P24.
(B) FISH analysis with the 11q23 specific BAC RP11-264L21 (green signals) and the Xq21 BAC RP11-325E14 (red signals). In the right cell, colocalization of one red and one of the three green signals indicates transfer of 11q23 sequences to Xq21 (white arrow).
Variants t(11;13)(q23;q14) is a variant translocation that rearranged ARHGAP20 with a novel gene on 13q14 (unpublished data).

Genes involved and Proteins

Gene NameBRWD3 (bromodomain and WD repeat domain containing 3)
Location Xq21.1
Note BRWD3 had been originally mapped to Xq13.3
Dna / Rna 5' telomeric --> 3' centromeric orientation; 44 exons spanning 132.7 kb genomic DNA; mRNA coding sequence: 4.2-5.4 kb
Protein Contains eight tandem WD40 repeats and two bromodomains; involved in the JAK/STAT signalling cascade.
Gene NameARHGAP20 (Rho GTPase activating protein 20)
Location 11q23.1
Dna / Rna 5' telomeric --> 3' centromeric orientation; 19 exons spanning 136.1 kb genomic DNA; mRNA coding sequence: 3.5-3.6 kb.
Protein Contains a RhoGAP domain in combination with PH and RA modules; involved in the regulation of Rho-family GTPases (e.g. regulating the neurite outhgrowth); cytoplasmic localisation.

Result of the chromosomal anomaly

Hybrid gene
  Schematic representation of the ARHGAP20-BRWD3 gene rearrangement. Black ovals represent the centromeres. The gene loci and orientation of ARHGAP20 and BRWD3 and their promoter regions are indicated by red and green arrows and boxes, respectively. Black arrows and the dashed line indicate the position of the breakpoints.
 
Description der(11): 5' BRWD3 (exons 1-22) - 3' ARHGAP20 (exons 1e-15);
der(X): 5' ARHGAP20 (promoter-part of exon 1e) - 3' BRWD3 (exons 23-41);
BRWD3 and ARHGAP20 are in the same transcriptional directions, fusion transcripts, however, were not detected.
  
Fusion Protein
Note No fusion transcript expressed.
  

To be noted

Both t(X;11)(q21;q23) and the variant translocation t(11;13)(q23;q14) affect ARHGAP20, which resides within the critical 11q22-q23 deletion region in B-CLL. Deletion of this genomic region is associated with an aggressive course of B-CLL.
Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes.
Kalla C, Nentwich H, Schlotter M, Mertens D, Wildenberger K, Döhner H, Stilgenbauer S, Lichter P
Genes, chromosomes & cancer. 2005 ; 42 (2) : 128-143.
PMID 15543602
 

Citation

This paper should be referenced as such :
Kalla, C
t(X;11)(q21;q23)
Atlas Genet Cytogenet Oncol Haematol. 2007;11(1):32-33.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0X11q21q23ID1430.html


Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes ARHGAP20 BRWD3

Translocations implicated (Data extracted from papers in the Atlas)

 t(X;11)(q21;q23) BRWD3/ARHGAP20

External links

arrayMap (UZH-SIB Zurich)
Mitelman databaset(X;11)(q21;q23) [Case List]    t(X;11)(q21;q23) [Association List] Mitelman database (CGAP - NCBI)
arrayMap[select an item]
 
 
Disease databaset(X;11)(q21;q23) BRWD3/ARHGAP20
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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