| Clinics and Pathology |
| Disease | ANLL |
| Phenotype / cell stem origin | M5/M4; ALL at times, therapy related cases |
| Epidemiology | from infants to adults |
| Prognosis | poor |
| Cytogenetics |
| Cytogenetics Morphological | A high diversity of reported breakpoints on chromosome 10, from 10p11 to 10p15: remains to be fully studiedL |
| Additional anomalies | inv(11)(q13q23) is frequently acompanying the t(10;11); this is likely to be related to the transcription directions of the two genes |
| Genes involved and Proteins |
| Gene Name | AF10 |
| Location | 10p12 |
| Dna / Rna | 5' telomeric --> 3' centromeric orientation |
| Protein | contains 3 Zn fingezrs and a leucine zipper; nuclear localisation; transcription factor |
| Gene Name | MLL |
| Location | 11q23 |
| Dna / Rna | 21 exons, spanning over 100 kb; 13-15 kb mRNA |
| Protein | 431 kDa; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation |
| Result of the chromosomal anomaly |
| Description | 5' MLL - 3' AF10; variable breakpoints on both chromosomes; the fusion transcript on chromosome 11 is the crucial one; MLL and AF10 are in opposite transcriptional directions, wich may be cause of the complexity of the translocation |
| Description | N-term AT hook and DNA methyltransferase from MLL fused to the leucine zipper C-term of AF10 |
| Expression Localisation | nuclear localisation |
| External links |
| Other database | t(10;11)(p12;q23) | Mitelman database (CGAP - NCBI) |
| To be noted |
| having a glance at 11q23 rearrangements, gives an overview of related diseases |
| Bibliography |
| The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. |
| Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD |
| Blood. 1995 ; 86 (6) : 2073-2076. |
| PMID 7662954 |
| Contributor(s) |
| Written | 12-1997 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(10;11)(p12;q23). Atlas Genet Cytogenet Oncol Haematol. December 1997 . URL : http://AtlasGeneticsOncology.org/Anomalies/t1011.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/handle/2042/32072/12-1997-t1011.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Mar 9 12:37:44 CET 2013 |
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