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t(10;11)(p12;q23) KMT2A/MLLT10

Written1997-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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ICD-Morpho 9807/3 Mixed phenotype acute leukaemia with t(v;11q23); MLL rearranged
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9813/3 B lymphoblastic leukaemia/lymphoma with t(v;11q23); MLL rearranged
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
Atlas_Id 1025

Clinics and Pathology

Disease AML
Phenotype / cell stem origin M5/M4; ALL at times, therapy related cases
Epidemiology from infants to adults
Prognosis poor


Cytogenetics Morphological A high diversity of reported breakpoints on chromosome 10, from 10p11 to 10p15: remains to be fully studiedL
Additional anomalies inv(11)(q13q23) is frequently acompanying the t(10;11); this is likely to be related to the transcription directions of the two genes

Genes involved and Proteins

Gene NameMLLT10 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10)
Location 10p12.31
Dna / Rna 5' telomeric --> 3' centromeric orientation
Protein contains 3 Zn fingezrs and a leucine zipper; nuclear localisation; transcription factor
Gene NameKMT2A (myeloid/lymphoid or mixed lineage leukemia)
Location 11q23.3
Dna / Rna 21 exons, spanning over 100 kb; 13-15 kb mRNA
Protein 431 kDa; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation

Result of the chromosomal anomaly

Hybrid gene
Description 5' MLL - 3' AF10; variable breakpoints on both chromosomes; the fusion transcript on chromosome 11 is the crucial one; MLL and AF10 are in opposite transcriptional directions, wich may be cause of the complexity of the translocation
Fusion Protein
Description N-term AT hook and DNA methyltransferase from MLL fused to the leucine zipper C-term of AF10
Expression Localisation nuclear localisation

To be noted

having a glance at 11q23 rearrangements, gives an overview of related diseases


The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene.
Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD
Blood. 1995 ; 86 (6) : 2073-2076.
PMID 7662954


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 1997;1(2):102-103.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)

 t(10;11)(p12;q23) KMT2A/MLLT10

External links

KMT2A (11q23.3) MLLT10 (10p12.31)

KMT2A (11q23.3) MLLT10 (10p12.31)

Mitelman databaset(10;11)(p12;q23) [Case List]    t(10;11)(p12;q23) [Transloc-MCList] KMT2A/MLLT10 [Fusion-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9807/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9813/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9920/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
COSMIC_fusionKMT2A/MLLT10 KMT2A (11q23.3) MLLT10 (10p12.31)   [fusion2033]   [fusion2034]   [fusion2035]   [fusion2036]   [fusion2037]   [fusion2038]   [fusion2039]   [fusion2040]   [fusion2041]   [fusion2042]   [fusion2043]   [fusion2044]   [fusion2045]   [fusion2046]   [fusion2047]   [fusion2048]   [fusion2049]   [fusion2050]   [fusion2051]   [fusion2052]  
TICdbKMT2A/MLLT10  KMT2A (11q23.3) MLLT10 (10p12.31)
REVIEW articlesautomatic search in PubMed
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