Written | 1998-03 | Jean-Loup Huret |
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
ICD-Morpho | 9837/3 T lymphoblastic leukaemia/lymphoma |
Atlas_Id | 1108 |
Clinics and Pathology |
Disease | T-cell ALL |
Genes involved and Proteins |
Gene Name | TAL1 (T-cell acute leukemia 1) |
Location | 1p33 |
Dna / Rna | complex alternate splicing |
Protein | contains a basic Helix-Loop-Helix (DNA binding) domain; cforms heterodimers; transcription factor; role in haematopoietic cell differentiation |
Gene Name | TCTA (T-cell leukemia translocation-associated gene) |
Location | 3p21.31 |
Protein | contains a hydrophobic domain; may be a membrane associated protein |
Result of the chromosomal anomaly |
Description | TCTA and TAL1 are in opposite direction |
Description | it may be that the promoting regions from TCTA disregulate TAL1 expression |
Bibliography |
Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. |
Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR |
Cancer research. 1995 ; 55 (9) : 1917-1921. |
PMID 7728759 |
Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia. |
Aplan PD, Raimondi SC, Kirsch IR |
The Journal of experimental medicine. 1992 ; 176 (5) : 1303-1310. |
PMID 1402676 |
Citation |
This paper should be referenced as such : |
Huret, JL |
t(1;3)(p32;p21) |
Atlas Genet Cytogenet Oncol Haematol. 1998;2(3):93-93. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1031108ID1108.html |
Other genes implicated (Data extracted from papers in the Atlas) [ 2 ] |
Genes | TAL1 | TCTA |
Translocations implicated (Data extracted from papers in the Atlas) |
t(1;3)(p32;p21) TCTA/TAL1 | |
External links |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:26:24 CET 2020 |
For comments and suggestions or contributions, please contact us