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t(1;3)(p32;p21) TCTA/TAL1

Written1998-03Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9837/3 T lymphoblastic leukaemia/lymphoma
Atlas_Id 1108

Clinics and Pathology

Disease T-cell ALL

Genes involved and Proteins

Gene Name TAL1
Location 1p32
Dna / Rna complex alternate splicing
Protein contains a basic Helix-Loop-Helix (DNA binding) domain; cforms heterodimers; transcription factor; role in haematopoietic cell differentiation
Gene Name TCTA
Location 3p21
Protein contains a hydrophobic domain; may be a membrane associated protein

Result of the chromosomal anomaly

Hybrid gene
Description TCTA and TAL1 are in opposite direction
  
Fusion Protein
Description it may be that the promoting regions from TCTA disregulate TAL1 expression
  

Bibliography

Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.
Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR
Cancer research. 1995 ; 55 (9) : 1917-1921.
PMID 7728759
 
Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia.
Aplan PD, Raimondi SC, Kirsch IR
The Journal of experimental medicine. 1992 ; 176 (5) : 1303-1310.
PMID 1402676
 

Citation

This paper should be referenced as such :
Huret, JL
t(1;3)(p32;p21)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(3):93-93.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1031108ID1108.html


Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes TAL1 TCTA

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;3)(p32;p21) TCTA/TAL1

External links

TCTA (3p21.31) TAL1 (1p33)

Mitelman databaset(1;3)(p32;p21) [Case List]    t(1;3)(p32;p21) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9837/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
Mitelman databaseTCTA/TAL1 [MCList]  TCTA (3p21.31) TAL1 (1p33)
 
Disease databaset(1;3)(p32;p21) TCTA/TAL1
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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