| Written | 1998-03 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9837/3 T lymphoblastic leukaemia/lymphoma |
| Atlas_Id | 1108 |
| Clinics and Pathology |
| Disease | T-cell ALL |
| Genes involved and Proteins |
| Gene Name | TAL1 (T-cell acute leukemia 1) |
| Location | 1p33 |
| Dna / Rna | complex alternate splicing |
| Protein | contains a basic Helix-Loop-Helix (DNA binding) domain; cforms heterodimers; transcription factor; role in haematopoietic cell differentiation |
| Gene Name | TCTA (T-cell leukemia translocation-associated gene) |
| Location | 3p21.31 |
| Protein | contains a hydrophobic domain; may be a membrane associated protein |
| Result of the chromosomal anomaly |
| Description | TCTA and TAL1 are in opposite direction |
| Description | it may be that the promoting regions from TCTA disregulate TAL1 expression |
| Bibliography |
| Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. |
| Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR |
| Cancer research. 1995 ; 55 (9) : 1917-1921. |
| PMID 7728759 |
| Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia. |
| Aplan PD, Raimondi SC, Kirsch IR |
| The Journal of experimental medicine. 1992 ; 176 (5) : 1303-1310. |
| PMID 1402676 |
| Citation |
| This paper should be referenced as such : |
| Huret, JL |
| t(1;3)(p32;p21) |
| Atlas Genet Cytogenet Oncol Haematol. 1998;2(3):93-93. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t1031108ID1108.html |
| Other genes implicated (Data extracted from papers in the Atlas) [ 2 ] |
| Genes | TAL1 | TCTA |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(1;3)(p32;p21) TCTA/TAL1 | |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Aug 28 18:17:53 CEST 2018 |
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