Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(11;12)(q23;q13) /HMGA2

Written2005-05Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
Atlas_Id 1390

Clinics and Pathology

Disease treatment related myelodysplastic syndrome (t-MDS)
Epidemiology only 1 case to date: a 48yr old female patient with refractory anaemia with excess of blasts (RAEB1) 4 yrs after treatment of a M0-AML with a normal karyotype
Prognosis The RAEB evolved towards a M2-AML and the patient died 6 mths after diagnosis

Genes involved and Proteins

Gene Name HMGA2
Location 12q15
Protein probable role in regulation of cell proliferation (transcriptional regulation of cell cycle and DNA repair genes

Result of the chromosomal anomaly

Fusion Protein
Description ectopic expression of HMGA2
  

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies.
Odero MD, Grand FH, Iqbal S, Ross F, Roman JP, Vizmanos JL, Andrieux J, Laï JL, Calasanz MJ, Cross NC
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (2) : 245-252.
PMID 15618963
 

Citation

This paper should be referenced as such :
Huret, JL
t(11;12)(q23;q13) /HMGA2
Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):255-255.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1112q23q13ID1390.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;12)(q23;q13) /HMGA2

External links

Mitelman databaset(11;12)(q23;q13) [Case List]    t(11;12)(q23;q13) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9920/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(11;12)(q23;q13) /HMGA2
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jan 21 16:50:32 CET 2017


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.