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t(11;12)(q23;q13) /HMGA2

Written2005-05Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

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ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
Atlas_Id 1390

Clinics and Pathology

Disease treatment related myelodysplastic syndrome (t-MDS)
Epidemiology only 1 case to date: a 48yr old female patient with refractory anaemia with excess of blasts (RAEB1) 4 yrs after treatment of a M0-AML with a normal karyotype
Prognosis The RAEB evolved towards a M2-AML and the patient died 6 mths after diagnosis

Genes involved and Proteins

Gene NameHMGA2 (high mobility group AT-hook 2)
Location 12q14.3
Protein probable role in regulation of cell proliferation (transcriptional regulation of cell cycle and DNA repair genes

Result of the chromosomal anomaly

Fusion Protein
Description ectopic expression of HMGA2

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies.
Odero MD, Grand FH, Iqbal S, Ross F, Roman JP, Vizmanos JL, Andrieux J, Laï JL, Calasanz MJ, Cross NC
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (2) : 245-252.
PMID 15618963


This paper should be referenced as such :
Huret, JL
t(11;12)(q23;q13) /HMGA2
Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):255-255.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)

 t(11;12)(q23;q13) /HMGA2

External links

Mitelman databaset(11;12)(q23;q13) [Case List]    t(11;12)(q23;q13) [Transloc-MCList] /HMGA2 [Fusion-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9920/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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