| Clinics and Pathology |
| Disease | multiple myeloma (MM) is a malignant plasma cell proliferation |
| Phenotype / cell stem origin | phenotype of mature differenciated B-cell, but also with CD56 expression, which is not found in normal plasma cells |
| Epidemiology | multiple myeloma's annual incidence: 30/106; mean age: 62 yrs; t(11;14) is found in 10-20% of cases of MM with an abnormal karyotype; t(11;14) is not found associated with particular sex or age group; found mostly in stage III MM |
| Clinics | bone pain; susceptibility to infections; renal failure; neurologic dysfunctions |
| Pathology | MM staging: stage I: low tumour cell mass; normal Hb; low serum calcium; no bone lesion; low monoclonal Ig rate; stage II: fitting neither stage I nor stage II; stage III: high tumour cell mass; low Hb and/or high serum calcium and/or advanced lytic bone lesions and/or high monoclonal Ig rate |
| Prognosis | evolution: multiple myeloma can evolve towards plasma cell leukemia; prognosis (highly variable) is according to the staging and other parameters, of which are now the karyotypic findings |
| Cytogenetics |
| Cytogenetics Morphological | t(11;14) is balanced in most cases; some cases are: -14, +der(14)t(11;14); t(11;14) may well be a secondary event in MM, lsas it has been found occurring during course of the disease |
| Cytogenetics Molecular | FISH is indicated, as metaphases are arduous to obtain in such a disease implicating mature cells |
| Additional anomalies | t(11;14) is part of a complex karyotype; accompanied with -13 or del(13q) in 'only' 1/4 of cases while -13/del(13q) is found in about 40% of MM cases with an abnormal karyotype; structural (and variable) anomalies of chromosome 1 are found in 1/3 of cases with t(11;14) |
| Variants | complex three way translocations t(11;Var;14) have been described |
| Genes involved and Proteins |
| Gene Name | BCL1 |
| Location | 11q13 |
| Gene Name | IgH |
| Location | 14q32 |
| External links |
| Other database | t(11;14)(q13;q32) in multiple myeloma | Mitelman database (CGAP - NCBI) | |
| Other database | t(11;14)(q13;q32) in multiple myeloma | CancerChromosomes (NCBI) |
| Bibliography |
| Cytogenetics and molecular genetics in multiple myeloma. |
| Feinman R, Sawyer J, Hardin J, Tricot G |
| Hematology/oncology clinics of North America. 1997 ; 11 (1) : 1-25. |
| PMID 9081201 |
| Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant. |
| LaˆØ JL, Michaux L, Dastugue N, Vasseur F, Daudignon A, Facon T, Bauters F, Zandecki M |
| Cancer genetics and cytogenetics. 1998 ; 104 (2) : 133-138. |
| PMID 9666807 |
| Contributor(s) |
| Written | 01-1998 | Jean-Loup Huret and Jean-Luc Laï |
| INSERM Unité 524, Institut de Recherche sur le Cancer de Lille, Lille, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL and Laï JL . t(11;14)(q13;q32) in multiple myeloma. Atlas Genet Cytogenet Oncol Haematol. January 1998 . URL : http://AtlasGeneticsOncology.org/Anomalies/t1114MM.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:58 2008 |
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