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t(11;14)(q13;q32) IGH/CCND1 in multiple myeloma

Written1998-01Jean-Loup Huret, Jean-Luc Laï
INSERM Unité 524, Institut de Recherche sur le Cancer de Lille, Lille, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9732/3 Plasma cell myeloma / Multiple myeloma
Atlas_Id 2054
 
  t(11;14)(q13;q32) with CCND1/IgH rerrangement R- banding and FISH - Courtesy Hossein Mossafa.

Clinics and Pathology

Disease multiple myeloma (MM) is a malignant plasma cell proliferation
Phenotype / cell stem origin phenotype of mature differenciated B-cell, but also with CD56 expression, which is not found in normal plasma cells
Epidemiology multiple myeloma's annual incidence: 30/106; mean age: 62 yrs; t(11;14) is found in 10-20% of cases of MM with an abnormal karyotype; t(11;14) is not found associated with particular sex or age group; found mostly in stage III MM
Clinics bone pain; susceptibility to infections; renal failure; neurologic dysfunctions
Pathology MM staging: stage I: low tumour cell mass; normal Hb; low serum calcium; no bone lesion; low monoclonal Ig rate; stage II: fitting neither stage I nor stage II; stage III: high tumour cell mass; low Hb and/or high serum calcium and/or advanced lytic bone lesions and/or high monoclonal Ig rate
Prognosis evolution: multiple myeloma can evolve towards plasma cell leukemia; prognosis (highly variable) is according to the staging and other parameters, of which are now the karyotypic findings

Cytogenetics

Cytogenetics Morphological t(11;14) is balanced in most cases; some cases are: -14, +der(14)t(11;14); t(11;14) may well be a secondary event in MM, lsas it has been found occurring during course of the disease
Cytogenetics Molecular FISH is indicated, as metaphases are arduous to obtain in such a disease implicating mature cells
Additional anomalies t(11;14) is part of a complex karyotype; accompanied with -13 or del(13q) in 'only' 1/4 of cases while -13/del(13q) is found in about 40% of MM cases with an abnormal karyotype; structural (and variable) anomalies of chromosome 1 are found in 1/3 of cases with t(11;14)
Variants complex three way translocations t(11;Var;14) have been described

Genes involved and Proteins

Gene NameCCND1 (B-cell leukemia/lymphoma 1)
Location 11q13.3
Gene NameIGH (Immunoglobulin Heavy)
Location 14q32.33

Bibliography

Cytogenetics and molecular genetics in multiple myeloma.
Feinman R, Sawyer J, Hardin J, Tricot G
Hematology/oncology clinics of North America. 1997 ; 11 (1) : 1-25.
PMID 9081201
 
Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant.
Laï JL, Michaux L, Dastugue N, Vasseur F, Daudignon A, Facon T, Bauters F, Zandecki M
Cancer genetics and cytogenetics. 1998 ; 104 (2) : 133-138.
PMID 9666807
 

Citation

This paper should be referenced as such :
Huret, JL ; Laï, JL
t(11;14)(q13;q32) in multiple myeloma
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):34-34.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1114MMID2054.html


Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes CD38 MYEOV

Translocations implicated (Data extracted from papers in the Atlas)

 t(11;14)(q13;q32) IGH/CCND1 in multiple myeloma

External links

IGH (14q32.33) CCND1 (11q13.3)

Mitelman databaset(11;14)(q13;q32) [Case List]    t(11;14)(q13;q32) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9732/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
Mitelman databaseIGH/CCND1 [MCList]  IGH (14q32.33) CCND1 (11q13.3)
 
Disease databaset(11;14)(q13;q32) IGH/CCND1 in multiple myeloma
REVIEW articlesautomatic search in PubMed
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