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t(11;14)(q13;q32) IGH/CCND1 in multiple myeloma

Written1998-01Jean-Loup Huret, Jean-Luc Laï
INSERM Unité 524, Institut de Recherche sur le Cancer de Lille, Lille, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9732/3 Plasma cell myeloma / Multiple myeloma
Atlas_Id 2054
 
  t(11;14)(q13;q32) with CCND1/IgH rerrangement R- banding and FISH - Courtesy Hossein Mossafa.

Clinics and Pathology

Disease multiple myeloma (MM) is a malignant plasma cell proliferation
Phenotype / cell stem origin phenotype of mature differenciated B-cell, but also with CD56 expression, which is not found in normal plasma cells
Epidemiology multiple myeloma's annual incidence: 30/106; mean age: 62 yrs; t(11;14) is found in 10-20% of cases of MM with an abnormal karyotype; t(11;14) is not found associated with particular sex or age group; found mostly in stage III MM
Clinics bone pain; susceptibility to infections; renal failure; neurologic dysfunctions
Pathology MM staging: stage I: low tumour cell mass; normal Hb; low serum calcium; no bone lesion; low monoclonal Ig rate; stage II: fitting neither stage I nor stage II; stage III: high tumour cell mass; low Hb and/or high serum calcium and/or advanced lytic bone lesions and/or high monoclonal Ig rate
Prognosis evolution: multiple myeloma can evolve towards plasma cell leukemia; prognosis (highly variable) is according to the staging and other parameters, of which are now the karyotypic findings

Cytogenetics

Cytogenetics Morphological t(11;14) is balanced in most cases; some cases are: -14, +der(14)t(11;14); t(11;14) may well be a secondary event in MM, lsas it has been found occurring during course of the disease
Cytogenetics Molecular FISH is indicated, as metaphases are arduous to obtain in such a disease implicating mature cells
Additional anomalies t(11;14) is part of a complex karyotype; accompanied with -13 or del(13q) in 'only' 1/4 of cases while -13/del(13q) is found in about 40% of MM cases with an abnormal karyotype; structural (and variable) anomalies of chromosome 1 are found in 1/3 of cases with t(11;14)
Variants complex three way translocations t(11;Var;14) have been described

Genes involved and Proteins

Gene Name CCND1
Location 11q13
Gene Name IGH
Location 14q32

Bibliography

Cytogenetics and molecular genetics in multiple myeloma.
Feinman R, Sawyer J, Hardin J, Tricot G
Hematology/oncology clinics of North America. 1997 ; 11 (1) : 1-25.
PMID 9081201
 
Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant.
Laï JL, Michaux L, Dastugue N, Vasseur F, Daudignon A, Facon T, Bauters F, Zandecki M
Cancer genetics and cytogenetics. 1998 ; 104 (2) : 133-138.
PMID 9666807
 

Citation

This paper should be referenced as such :
Huret, JL ; Laï, JL
t(11;14)(q13;q32) in multiple myeloma
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):34-34.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1114MMID2054.html


Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes CD38 MYEOV

Translocations implicated (Data extracted from papers in the Atlas)

 t(11;14)(q13;q32) IGH/CCND1 in multiple myeloma

External links

IGH (14q32.33) CCND1 (11q13.3)

Mitelman databaset(11;14)(q13;q32) [Case List]    t(11;14)(q13;q32) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9732/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
Mitelman databaseIGH/CCND1 [MCList]  IGH (14q32.33) CCND1 (11q13.3)
 
Disease databaset(11;14)(q13;q32) IGH/CCND1 in multiple myeloma
REVIEW articlesautomatic search in PubMed
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