t(11;14)(p11;q32)

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t(11;14)(p11;q32)

Written	2002-01	Antonio Cuneo
		Hematology Section, Dept. Of Biomedical Sciences, University of Ferrara, 44100 Ferrara Italy

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS

Atlas_Id 2116

Clinics and Pathology

Disease Splenic marginal zone B-cell lymphoma (MZBCL)

Phenotype / cell stem origin CD19+; CD5-; CD22+; CD23-; CD10-; CD25-/+; CD38+; CD11c-; CD103-; FMC7+; surface Ig bright+. The transformed cell represents an IgM+/IgD+ B-lymphocyte deriving from the marginal zone.

Epidemiology The translocation is rare (<1% of B-cell chronic lymphoid neoplasias)

Clinics These patients may feature a relatively aggressive clinical course as compared with other cases of splenic MZBCL

Cytology Usually, the abnormal lymphocytes in the PB smear are morphologically heterogeneous. The majority of cells are >14 mm in size, with pleomorphism of nuclear shapes, fine chromatin structure and distinct nucleoli. Some lymphocytes with short villi may be present along with larger lymphoid cells and rare prolymphocyte-like cells.

Pathology The bone biopsy may show B-lymphoid cells of intermediate size with an interstitial infiltration pattern. An intrasinusoidal pattern of growth was also noted.
The spleen specimens display a nodular lymphoid infiltrate of the white pulp by small lymphocytes mixed with larger blast cells with clear cytoplasm, centered on polyclonal follicle centers. Red pulp involvement may occur.

Treatment The patients may show partial responses to alkylating agent and to multiagenet chemotherapy.

Evolution Transformation into high-grade lymphoma was reported.

Cytogenetics

Cytogenetics Morphological The tranlocation was described as a balanced t(11;14)(p11;q32).

Cytogenetics Molecular To detect the 14q32 break, the cos-Ca1, cosIg6 and cos3/64 and YAC Y6 were used. Splitting of cosmid signals and Y6 signals has been detected, indicating a break downstream of the IgVH sequences, in the region flanked by cos3/64 and Y6. The gene involved at the 11p11 band is presently unknown.

Additional anomalies del(7)(q22q32); +12; del(17)(p12). In one case a 7q- chromosome was the primary anomaly, the t(11;14) having found at the time of histologic transformation into high grade lymphoma

Bibliography

Nonrandom chromosome abnormalities in lymphoma.

Bloomfield CD, Arthur DC, Frizzera G, Levine EG, Peterson BA, Gajl-Peczalska KJ

Cancer research. 1983 ; 43 (6) : 2975-2984.

PMID 6850608

A novel recurrent translocation t(11;14)(p11;q32) in splenic marginal zone B cell lymphoma.

Cuneo A, Bardi A, Wlodarska I, Selleslag D, Roberti MG, Bigoni R, Cavazzini F, De Angeli C, Tammiso E, del Senno L, Cavazzini P, Hagemeijer A, Castoldi G

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2001 ; 15 (8) : 1262-1267.

PMID 11480569

The Non-Hodgkin's Lymphomas. Pp 277-308.

WhangPeng J, Knutsen T, in: Magrath I ed

Arnold, London. 1997.

Citation

This paper should be referenced as such :

Cuneo, A

t(11;14)(p11;q32)

Atlas Genet Cytogenet Oncol Haematol. 2002;6(2):127-127.

Free journal version : [ pdf ] [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Anomalies/t1114p11q32ID2116.html

Translocations implicated (Data extracted from papers in the Atlas)

t(11;14)(p11;q32)

External links

Mitelman database t(11;14)(p11;q32)
arrayMap (UZH-SIB Zurich) [select an item]

REVIEW articles automatic search in PubMed

Last year articles automatic search in PubMed

All articles automatic search in PubMed

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ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id	2116

Disease	Splenic marginal zone B-cell lymphoma (MZBCL)
Phenotype / cell stem origin	CD19+; CD5-; CD22+; CD23-; CD10-; CD25-/+; CD38+; CD11c-; CD103-; FMC7+; surface Ig bright+. The transformed cell represents an IgM+/IgD+ B-lymphocyte deriving from the marginal zone.
Epidemiology	The translocation is rare (<1% of B-cell chronic lymphoid neoplasias)
Clinics	These patients may feature a relatively aggressive clinical course as compared with other cases of splenic MZBCL
Cytology	Usually, the abnormal lymphocytes in the PB smear are morphologically heterogeneous. The majority of cells are >14 mm in size, with pleomorphism of nuclear shapes, fine chromatin structure and distinct nucleoli. Some lymphocytes with short villi may be present along with larger lymphoid cells and rare prolymphocyte-like cells.
Pathology	The bone biopsy may show B-lymphoid cells of intermediate size with an interstitial infiltration pattern. An intrasinusoidal pattern of growth was also noted. The spleen specimens display a nodular lymphoid infiltrate of the white pulp by small lymphocytes mixed with larger blast cells with clear cytoplasm, centered on polyclonal follicle centers. Red pulp involvement may occur.
Treatment	The patients may show partial responses to alkylating agent and to multiagenet chemotherapy.
Evolution	Transformation into high-grade lymphoma was reported.

Cytogenetics Morphological	The tranlocation was described as a balanced t(11;14)(p11;q32).
Cytogenetics Molecular	To detect the 14q32 break, the cos-Ca1, cosIg6 and cos3/64 and YAC Y6 were used. Splitting of cosmid signals and Y6 signals has been detected, indicating a break downstream of the IgVH sequences, in the region flanked by cos3/64 and Y6. The gene involved at the 11p11 band is presently unknown.
Additional anomalies	del(7)(q22q32); +12; del(17)(p12). In one case a 7q- chromosome was the primary anomaly, the t(11;14) having found at the time of histologic transformation into high grade lymphoma

Mitelman database	t(11;14)(p11;q32)
arrayMap (UZH-SIB Zurich)	[select an item]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed