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t(11;14)(p13;q32) IGH/CD44

Written2018-08Jean-Loup Huret
jean-loup.huret@atlasgeneticsoncology.org

Abstract Review on t(11;14)(p13;q32), with data on clinics, and the genes involved.

Keywords Chromosome 11; chromosome 14; IGH; CD44; gastric lymphomas, nongastric extranodal lymphomas, nodal follicular lymphomas, nodal diffuse large B-cell lymphoma

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424
ICD-Morpho 9699/3 Extranodal marginal zone lymphoma of mucosa- associated lymphoid tissue (MALT lymphoma); Nodal marginal zone lymphoma; Paediatric nodal marginal zone lymphoma
ICD-Morpho 9690/3 Follicular lymphoma; Paediatric follicular lymphoma
ICD-Morpho 9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS; Primary DLBCL of the CNS; Primary cutaneous DLBCL, leg type; EBV positive DLBCL of the elderly; DLBCL associated with chronic inflammation; B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
Atlas_Id 1609

Clinics and Pathology

Disease Mature B-cell non-Hodgkin Lymphomas (NHL).
Note Nine cases available so far, from a unique study (Hu et al., 2010).
Phenotype / cell stem origin In a study of 114 cases of mature B-cell NHLs, the t(11;14)(p13;q32) IGH/CD44 was found in:
  • 4 cases (8%) of gastric lymphoma; mucosa-associated lymphoid lymphoma (MALT): 1 (25%); composite DLBCL with residual MALT lymphoma: 2 (33%); diffuse large B-cell lymphoma (DLBCL) germinal center B-cell-like (GCB)-type: 1 (4%);
  • 2 cases (25%) of non-gastric extranodal lymphoma: DLBCL GCB-type: 2 (67%);
  • 2 cases (7%) of follicular lymphoma (FL), one of which also harboring a t(14;18)(q32;q21) IGH/BCL2;
  • 1 cases (4%) of nodal DLBCL GCB-type.
  • Genes involved and Proteins

    Gene NameCD44
    Location 11p13
    Dna / Rna 20 exons spanning 60 kb. The first five and the last five exons are constant; while the ten exons located between, are subject to alternative splicing, resulting in the generation of CD44 variants.
    Protein CD44 is composed of extracellular, transmembrane, and cytoplasmic domains. CD44 is a membrane receptor which plays a role in cell adhesion (cell-cell and cell-extracellular matrix interactions), cell traffic, presentation of chemokines and growth factors, signals transmission. High levels of expression of CD44 have been observed in a high number of cancer types, including non-Hodgkin Lymphomas (Sen and Yip 2010).
    Gene NameIGH
    Location 14q32.33

    Result of the chromosomal anomaly

    Hybrid gene
    Description 5' IGH-3' CD44. The translocation juxtaposes the IGHSμ enhancer to the 5' regulatory region of CD44 in a tail-to-head orientation. Various breakpoints: breakpoints were spread within small regions of IGHSμ and small regions between CD44 exon 1 and 2.
      
    Fusion Protein
    Description CD44 starting from the ATG at nucleotide 254 with a strong Kozak sequence.
    Oncogenesis The ectopic expression of CD44 resulted in increase in cell growth and clonogenicity. To be noted is that the t(11;14)(p13;q32) was detected in 4 patients with advanced stages of disease.
      

    To be noted

    Additional cases are needed to delineate the epidemiology of this rare entity:
    you are welcome to submit a paper to our new Case Report section.

    Bibliography

    CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation.
    Hu XT, Chen YW, Liang AC, Au WY, Wong KY, Wan TS, Wong ML, Shen L, Chan KK, Guo T, Chu KM, Tao Q, Chim CS, Loong F, Choi WW, Lu L, So CC, Chan LC, Kwong YL, Liang RH, Srivastava G.
    Blood. 2010 Mar 25;115(12):2458-61. doi: 10.1182/blood-2009-09-238782. Epub 2010 Jan 21.
    PMID 20093404
     
    CD44 (CD44 molecule (Indian blood group))
    Sen YP ; Yip GW
    Atlas Genet Cytogenet Oncol Haematol. 2010;14(2):95-102. http://AtlasGeneticsOncology.org/Genes/CD44ID980CH11p13.html
     

    Citation

    This paper should be referenced as such :
    Huret JL
    t(11;14)(p13;q32) IGH/CD44;
    Atlas Genet Cytogenet Oncol Haematol. in press
    On line version : http://AtlasGeneticsOncology.org/Anomalies/t1114p13q32ID1609.html


    Translocations implicated (Data extracted from papers in the Atlas)

     t(11;14)(p13;q32) IGH/CD44

    External links

    Mitelman databaset(11;14)(p13;q32) [Case List]    t(11;14)(p13;q32) [Transloc-MCList] IGH/CD44 [Fusion-MCList]
    arrayMap (UZH-SIB Zurich)Morph ( 9699/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
    arrayMap (UZH-SIB Zurich)Morph ( 9690/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
    arrayMap (UZH-SIB Zurich)Morph ( 9680/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
     
     
    REVIEW articlesautomatic search in PubMed
    Last year articlesautomatic search in PubMed
    All articlesautomatic search in PubMed


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    indexed on : Wed Nov 28 16:19:16 CET 2018


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